DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5003 and Fbxl18

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_006248969.1	Gene:	Fbxl18 / 678726	RGDID:	1596958	Length:	707	Species:	Rattus norvegicus

Alignment Length:	733	Identity:	137/733 - (18%)
Similarity:	229/733 - (31%)	Gaps:	277/733 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 ECNLMDFCDELLFEIFQYL-DTSSILAVMHCSPRFENLLLDHRFYHHI----DLSNGPLPMGILE 125
            :.:|:.|.||:|..|..:: .|..:|.|.....:...|.||....|.:    |.......:..|.
  Rat    14 DTHLLGFSDEILLHILSHVPSTDLVLNVRRTCRKLAALCLDKSLVHTVLLQKDYQASEEKVKQLV 78

  Fly   126 EILGRATEKTHTIKICGPPSS--QHVAGEFRQFTQTLSSVFPRVVQLKVLELEGVSLDFEYIHIT 188
            :.:||..::.:.......|.|  :|||               |...|..:.|.|       .|:|
  Rat    79 KEIGREIQQLNMAGCYWLPGSTIEHVA---------------RCHSLVKVNLSG-------CHLT 121

  Fly   189 EFPATLRRLKLKDCSVRVGDTPKSIFYSIELHLLDLEDLSIEDNSWFEPYYIMGLSKLPSLRRLS 253
                :||..::..|..|                  |..|:|:.:..|:      .|:|.|..:.:
  Rat   122 ----SLRLSRVLSCLQR------------------LRSLAIDVSPGFD------ASQLSSECKAT 158

  Fly   254 LKGCQALCK--FVP-YGSMAARFGFQKLESLDLRQTPINNSDLQCFSAIENLKELLLESPQILHS 315
            |...|.|.:  |.| ||.:......|||              |..|..::..:|..:.|.|::
  Rat   159 LSRVQELKQTLFTPSYGVVPCCASLQKL--------------LLYFEILDRTREGAVLSGQLM-- 207

  Fly   316 KQAVAKKNTNGNATDEAASPQPDSLKVLSDDEPSTSRAAMEHLRACKVAFNLDNCSDRKEEKSPV 380
               |.:.|.          |...:|:|.      .:|.|..::....|...|...|||..|
  Rat   208 ---VGQSNV----------PHYQNLRVF------YARLAPGYINQEVVRLYLAVLSDRTPE---- 249

  Fly   381 PTEPPSEGQDLQAKRIRAP---SESDDEDTSSTSGSSSDKLEVLSLPRN---------------- 426
                     :|.|..|..|   :||........|.:.:..|:.|.||::
  Rat   250 ---------NLHAFLISVPGSFAESGATKNLLDSMARNVALDALQLPKSWLNGSTLLQHMKFNNP 305

  Fly   427 ------------GHSNAAPLSGGVDLPPLP------------------HAADAANAADAPIAVDA 461
                        ||.....::||.||..|.                  .|.|..:::.....|::
  Rat   306 FYFSFSRCTLSGGHLIQRLINGGKDLRSLASLNLSGCVHCLSADSLLRKAEDDIDSSILETLVES 370

  Fly   462 A------NIEAP--GQSPGLD---------------------------PRPPRAYIYVPDAENAN 491
            .      |:.|.  ..|.||.                           |||.||  ..|.|.:|.
  Rat   371 CCNLHHLNLSAAHHHSSDGLGRHLCQLLARLCHLRSLSLPVCSVADSAPRPDRA--PAPPAMHAV 433

  Fly   492 PRQQRSVVAVFAQGTEQRYIYVNQQFSLPMNVLMPTRRHRTHPRPNYDQVVQHP--MFWNM---- 550
            ||.....|.:..|                           |.|.|...|....|  :||::
  Rat   434 PRGFGKKVRIGVQ---------------------------TCPNPFVGQSAPQPASVFWSLLKKL 471

  Fly   551 -----LEPLDRDYAR-------RVRPRPPSCQTTPQYYVTDRAMYSFGRADRPVQPDVVWIRNIN 603
                 ||.:..:::.       .:|...|.|.....  |.|..:.:.|:        :.::|::.
  Rat   472 PFLEHLELIGSNFSSAMPRNEPAIRNSLPPCSRAQN--VGDSEVAAIGQ--------LTFLRHLT 526

  Fly   604 RSPDNKLERLSLRNYHLITNHTLEHL-VQC----SPNLVYIDVSGTSITLPAIRRFKISKPKCEV 663
                  |.:|.    .::|...|..: :||    |.:|..:.:.|..:.:||:
  Rat   527 ------LAQLP----GMLTGSGLVSIGLQCQQLQSLSLANLGMMGKVVYMPAL------------ 569

  Fly   664 VANHLEEFERLPELETQE 681
             |:.|:..:||.:|..::
  Rat   570 -ADMLKHCKRLKDLRLEQ 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	13/50 (26%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381	7/29 (24%)
Fbxl18	XP_006248969.1	F-box-like	22..64	CDD:289689	11/41 (27%)
		leucine-rich repeat	334..373	CDD:275381	4/38 (11%)
		leucine-rich repeat	374..403	CDD:275381	5/28 (18%)
		leucine-rich repeat	404..473	CDD:275381	19/97 (20%)
		leucine-rich repeat	522..548	CDD:275381	7/35 (20%)
		leucine-rich repeat	549..578	CDD:275381	7/41 (17%)
		leucine-rich repeat	579..604	CDD:275381	2/8 (25%)
		leucine-rich repeat	605..629	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346608
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030