Protein Alignment CG5003 and SKP2

DIOPT Version :10

• Sequence 1: NP_651593.1
• Gene: CG5003 / 43344
• FlyBaseID: FBgn0039554
• Length: 713
• Species: Drosophila melanogaster
• Sequence 2: NP_005974.2
• Gene: SKP2 / 6502
• HGNCID: 10901
• Length: 424
• Species: Homo sapiens
• Alignment Length: 330
• Identity: 73/330 - (22%)
• Similarity: 110/330 - (33%)
• Gaps: 89/330 - (26%)

  Fly    11 LAAPKRRFPDNERCGRELAAVPVQPVLPQIPTEEEPEIKQRKREKEHKESLD----RETECNLMD 71
            ::|.::..||:|...:||           :.....||...|||.|......|    |..:.|..:
Human    38 VSALEKEEPDSENIPQEL-----------LSNLGHPESPPRKRLKSKGSDKDFVIVRRPKLNREN 91

  Fly    72 F--------CDELLFEIFQYLDTSSILAVMHCSPRFENLLLDHRFYHHIDLSNGPLPMGILEEIL 128
            |        .||||..||..|....:|.|.....|:..|..|...:..:||:...|...:...:|
Human    92 FPGVSWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLL 156

  Fly   129 GRATEKTHTIKICGPPS--SQHVAGEFRQFTQTLSSVFPRVVQLKVLELEGVSLDFEYIHITEFP 191
            .:.     .|....|.|  .|.:|..|..|......:...|::  |..|.|:
Human   157 SQG-----VIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIE--VSTLHGI------------- 201

  Fly   192 ATLRRLKLKDCSVRVGDTPKSIFYSIELHLLDLEDLSIEDNSWFEPYYIMGLSKLPSLRRLSLKG 256
                   |..||              :|..|.||.|.:.|.      .:..|:|..:|.||:|.|
Human   202 -------LSQCS--------------KLQNLSLEGLRLSDP------IVNTLAKNSNLVRLNLSG 239

  Fly   257 CQALCKFVPYGSMAARFGFQKLESLDLRQTPINNSDLQCFSAIENLKELLLESPQILHSKQAVAK 321
            |...          :.|..|.|.|...|...:|.|  .||...|...::     .:.|..:.:.:
Human   240 CSGF----------SEFALQTLLSSCSRLDELNLS--WCFDFTEKHVQV-----AVAHVSETITQ 287

  Fly   322 KNTNG 326
            .|.:|
Human   288 LNLSG 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	69..111	CDD:425796	13/49 (27%)
		leucine-rich repeat	610..635	CDD:275381
SKP2	NP_005974.2	Mediates interaction with hepatitis C virus non-structural protein NS5A. /evidence=ECO:0000269|PubMed:27194766	1..220		51/233 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..73		12/44 (27%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:22770219	67..73		4/5 (80%)
		F-box_FBXL1	97..137	CDD:438886	12/39 (31%)
		leucine-rich repeat	183..207	CDD:275381	7/59 (12%)
		AMN1	193..>345	CDD:187754	33/159 (21%)
		leucine-rich repeat	208..231	CDD:275381	8/28 (29%)
		LRR 3. /evidence=ECO:0000269|PubMed:11099048	210..234		8/29 (28%)
		leucine-rich repeat	232..257	CDD:275381	10/34 (29%)
		LRR 4. /evidence=ECO:0000269|PubMed:11099048	235..257		8/31 (26%)
		leucine-rich repeat	258..284	CDD:275381	6/32 (19%)
		LRR 5. /evidence=ECO:0000269|PubMed:11099048	258..284		6/32 (19%)
		leucine-rich repeat	285..311	CDD:275381	2/8 (25%)
		LRR 6. /evidence=ECO:0000269|PubMed:11099048	286..308		2/7 (29%)
		LRR 7. /evidence=ECO:0000269|PubMed:11099048	309..330
		leucine-rich repeat	312..336	CDD:275381
		LRR 8. /evidence=ECO:0000269|PubMed:11099048	334..356
		leucine-rich repeat	337..356	CDD:275381
		LRR 9. /evidence=ECO:0000269|PubMed:11099048	359..378
		leucine-rich repeat	365..392	CDD:275381
		LRR 10. /evidence=ECO:0000269|PubMed:11099048	380..401
		Mediates interaction with IFI27. /evidence=ECO:0000269|PubMed:27194766	402..424