DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5003 and SKP2

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_005974.2	Gene:	SKP2 / 6502	HGNCID:	10901	Length:	424	Species:	Homo sapiens

Alignment Length:	330	Identity:	73/330 - (22%)
Similarity:	110/330 - (33%)	Gaps:	89/330 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LAAPKRRFPDNERCGRELAAVPVQPVLPQIPTEEEPEIKQRKREKEHKESLD----RETECNLMD 71
            ::|.::..||:|...:||           :.....||...|||.|......|    |..:.|..:
Human    38 VSALEKEEPDSENIPQEL-----------LSNLGHPESPPRKRLKSKGSDKDFVIVRRPKLNREN 91

  Fly    72 F--------CDELLFEIFQYLDTSSILAVMHCSPRFENLLLDHRFYHHIDLSNGPLPMGILEEIL 128
            |        .||||..||..|....:|.|.....|:..|..|...:..:||:...|...:...:|
Human    92 FPGVSWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLL 156

  Fly   129 GRATEKTHTIKICGPPS--SQHVAGEFRQFTQTLSSVFPRVVQLKVLELEGVSLDFEYIHITEFP 191
            .:.     .|....|.|  .|.:|..|..|......:...|::  |..|.|:
Human   157 SQG-----VIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIE--VSTLHGI------------- 201

  Fly   192 ATLRRLKLKDCSVRVGDTPKSIFYSIELHLLDLEDLSIEDNSWFEPYYIMGLSKLPSLRRLSLKG 256
                   |..||              :|..|.||.|.:.|.      .:..|:|..:|.||:|.|
Human   202 -------LSQCS--------------KLQNLSLEGLRLSDP------IVNTLAKNSNLVRLNLSG 239

  Fly   257 CQALCKFVPYGSMAARFGFQKLESLDLRQTPINNSDLQCFSAIENLKELLLESPQILHSKQAVAK 321
            |...          :.|..|.|.|...|...:|.|  .||...|...::     .:.|..:.:.:
Human   240 CSGF----------SEFALQTLLSSCSRLDELNLS--WCFDFTEKHVQV-----AVAHVSETITQ 287

  Fly   322 KNTNG 326
            .|.:|
Human   288 LNLSG 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	14/53 (26%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381
SKP2	NP_005974.2	Mediates interaction with hepatitis C virus non-structural protein NS5A. /evidence=ECO:0000269\|PubMed:27194766	1..220		51/233 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..73		12/44 (27%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:22770219	67..73		4/5 (80%)
		F-box-like	97..141	CDD:403981	12/43 (28%)
		leucine-rich repeat	183..207	CDD:275381	7/59 (12%)
		AMN1	193..>345	CDD:187754	33/159 (21%)
		leucine-rich repeat	208..231	CDD:275381	8/28 (29%)
		LRR 3. /evidence=ECO:0000269\|PubMed:11099048	210..234		8/29 (28%)
		leucine-rich repeat	232..257	CDD:275381	10/34 (29%)
		LRR 4. /evidence=ECO:0000269\|PubMed:11099048	235..257		8/31 (26%)
		leucine-rich repeat	258..284	CDD:275381	6/32 (19%)
		LRR 5. /evidence=ECO:0000269\|PubMed:11099048	258..284		6/32 (19%)
		leucine-rich repeat	285..311	CDD:275381	2/8 (25%)
		LRR 6. /evidence=ECO:0000269\|PubMed:11099048	286..308		2/7 (29%)
		LRR 7. /evidence=ECO:0000269\|PubMed:11099048	309..330
		leucine-rich repeat	312..336	CDD:275381
		LRR 8. /evidence=ECO:0000269\|PubMed:11099048	334..356
		leucine-rich repeat	337..356	CDD:275381
		LRR 9. /evidence=ECO:0000269\|PubMed:11099048	359..378
		leucine-rich repeat	365..392	CDD:275381
		LRR 10. /evidence=ECO:0000269\|PubMed:11099048	380..401
		Mediates interaction with IFI27. /evidence=ECO:0000269\|PubMed:27194766	402..424
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152994
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030