DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5003 and Fbxl7

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster

Alignment Length:	640	Identity:	143/640 - (22%)
Similarity:	207/640 - (32%)	Gaps:	216/640 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 RFENLLLDHRFYHH-IDLSNGPLP---------------MGILEEILGRATEKTHTIKICGPPSS 146
            |..|.:.||  ||| ..||:.||.               :.:.|.:..|::.         |||.
  Fly    22 RNSNAVRDH--YHHPHPLSSSPLDPQAYKMMSRKSPNPGLEVAEALASRSST---------PPSD 75

  Fly   147 QHVAGEFRQFTQTLSSVFPRVVQLK--VLELEG-----VSLDFEY-IHIT-----------EFPA 192
            |..|..    |...::|. .:||.|  ..||.|     ......| .|.|           |.||
  Fly    76 QAGASS----TAAAAAVL-HMVQQKAATFELRGRHSRPTEQQTSYGAHSTASVGRHAKKSPELPA 135

  Fly   193 TLRRLKLKDCSVRVGDTPKSIFYSIELHLL---------------DLEDLSIEDNSWFEPYYIMG 242
            ...|      :|.....|:: |.::| |:|               |.||.|  ||:........|
  Fly   136 PASR------NVAPVPQPRN-FLTLE-HVLQFGTQRPSWMHGNSADTEDSS--DNNAGGGGAGSG 190

  Fly   243 LSKLPSLRRLSLKGCQALCKFVP-------YGSMAARFGF-QKLESL----DLRQTPINN----- 290
            .......||.....|.     ||       .|...|::.. :|:|||    .||..|:..
  Fly   191 SGGAGGRRRAQGGRCS-----VPTVLSSNGSGGNGAQYLLDKKMESLYLGNALRTLPLGAEASQF 250

  Fly   291 -------SDLQCFSAIENLKELL----LESP-QILHSKQAVAKKNTNGNATDEAASPQPDSLKVL 343
                   .|....|..|.|.|.|    ..|| :...|.:.:..:::|.|..........|.|..|
  Fly   251 QNERYYLEDYSSGSGNERLPERLHHPRTSSPSETSGSDRYLLNRSSNSNHLHSKGQSLSDGLCNL 315

  Fly   344 SDDEPSTSRAAMEHLRACKVAFNLDNCSDRKEEKSPVPTEPPSEGQDLQAKRIRAPSESDDEDTS 408
            ....||..:.....:                   ||.||...|.|         ......:..|:
  Fly   316 GRFSPSLDQGYATLV-------------------SPSPTGHHSSG---------GAGNVTNSTTA 352

  Fly   409 STSGSSSDKLEVLSLPRNGHSNAAPLSGGVDLPPLPHAADAANAADAPIAVDAANIEAPGQSPGL 473
            |.:|..:..... :.||.|.|:.. |.||           ||:|...|    ..|.:.|.:...|
  Fly   353 SGAGIMASSTPT-TTPRRGASSNG-LGGG-----------AASAIGPP----PWNRKGPFRCGPL 400

  Fly   474 DPRPPRAYIYVPDAENANPRQQRSVVAVFA--QGTEQRYIYVNQQFSLPMNVLMPTRRHRTHPRP 536
            ..|       :||         .:||.:|:  ...|.            .||....||
  Fly   401 FDR-------LPD---------EAVVRIFSWLDSCEL------------CNVARVCRR------- 430

  Fly   537 NYDQVVQHPMFWNML----EPLDRDYARRVRPRP---PSCQ-TTPQYYVTDRAMYSFG--RADRP 591
             ::.:...|:.|.::    |.|:.|...::..|.   .||. ..|:   .:|.|.:.|  .:|:.
  Fly   431 -FEHLAWRPILWKVISLRGEHLNGDKTLKMIFRQLCGQSCNGACPE---VERVMLADGCRISDKG 491

  Fly   592 VQPDVVWIRNINRSPDNKLERLSLRNYHLITNHTL-EHLVQCSPNLVYIDVSGTS 645
            :|      ....|.|:  |..|.|:....|||..| |.|.:|| ||.::||:|.|
  Fly   492 LQ------LLTRRCPE--LTHLQLQTCVDITNQALVEALTKCS-NLQHLDVTGCS 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	7/16 (44%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381	11/25 (44%)
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	13/81 (16%)
		leucine-rich repeat	441..460	CDD:275381	4/18 (22%)
		AMN1	<451..595	CDD:187754	30/99 (30%)
		leucine-rich repeat	476..501	CDD:275381	6/30 (20%)
		leucine-rich repeat	502..521	CDD:275381	7/18 (39%)
		leucine-rich repeat	528..555	CDD:275381	5/10 (50%)
		leucine-rich repeat	556..581	CDD:275381
		AMN1	577..746	CDD:187754
		leucine-rich repeat	582..607	CDD:275381
		leucine-rich repeat	608..633	CDD:275381
		leucine-rich repeat	634..659	CDD:275381
		leucine-rich repeat	660..685	CDD:275381
		leucine-rich repeat	686..710	CDD:275381
		leucine-rich repeat	711..735	CDD:275381
		leucine-rich repeat	737..761	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457924
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840