DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5003 and CG12402

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster

Alignment Length:	402	Identity:	93/402 - (23%)
Similarity:	148/402 - (36%)	Gaps:	116/402 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 ESLDRETECNLMDF-CDELLFE-------IFQYLDTSSILAVMHCSPRF----ENLLLDHRFYH- 110
            :.||.:...:|:.| ||.:..:       :.|...|.:.:.:.|....|    ||.|||....|
  Fly   209 DDLDMKQFSHLVGFECDGVSLDAVLKMRMLLQLRRTENKVQLRHLQFEFRRNNENALLDVLQDHA 273

  Fly   111 ------HIDLSNGPLPMGILEEILGRATEKTH---TIKICG--------------PPSSQ----- 147
                  ::..|..|   ||......||.|..|   |:|:.|              |.|:.
  Fly   274 ETLVCVNLFFSCSP---GIDTREWCRAFENMHNLRTLKLSGNCHLVLLEAVLRAVPESAPIRQLD 335

  Fly   148 -------------HVAGEFRQFTQTLSSVFPRVVQLKVLELEGVSLDFEYIHITEFPATLRRLKL 199
                         :|||:::...:.|..:|  .|||....::.         :.:....|..|.:
  Fly   336 LTGMLSLTNELLLYVAGKWQSTLKVLDLMF--CVQLNANCIDA---------LRQLSGRLEALTM 389

  Fly   200 KDCSVRVG-----DTPKSIFYSI-ELHLLDLEDLSIEDNSWFEPYYIMGLSKLPSLRRLSLKGCQ 258
            ..|....|     .....|.||: ||||  .|.:.::::|..:.     |.:||:||||||..|:
  Fly   390 AYCRELTGTGLLQGLAGDINYSLQELHL--EETIFLDESSMCQL-----LERLPNLRRLSLDNCR 447

  Fly   259 ALCKFVPYGSMAARFGFQ-KLESLDLRQ-TPINNSDLQCF-------SAIENLKELLLES-PQIL 313
               :.|...:||....:| :|.:|::.. ..|.:..|..:       |.:..||||.|.. ..:.
  Fly   448 ---QAVTDRTMATICQYQTRLRNLNIEYCMKITDQGLMGYGDTPYPISRLRGLKELNLRGCRNVT 509

  Fly   314 HSKQAVAKK------------NTNGNATDEAASPQPDSLKVLS-------DDEPSTSRAAMEHLR 359
            .|...|..|            |...:...||.:....||:.|.       |||  |....:.:|:
  Fly   510 DSSLMVGLKLPELRALSLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDE--TVLNIVSNLK 572

  Fly   360 ACKVAFNLDNCS 371
            ..:| .||.||:
  Fly   573 RLRV-LNLSNCT 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	14/64 (22%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381	7/24 (29%)
		LRR_RI	<297..482	CDD:238064	46/205 (22%)
		leucine-rich repeat	304..330	CDD:275381	5/25 (20%)
		leucine-rich repeat	331..357	CDD:275381	3/25 (12%)
		leucine-rich repeat	358..379	CDD:275381	5/31 (16%)
		leucine-rich repeat	384..409	CDD:275381	4/24 (17%)
		leucine-rich repeat	412..437	CDD:275381	8/31 (26%)
		AMN1	430..595	CDD:187754	43/165 (26%)
		leucine-rich repeat	438..464	CDD:275381	11/28 (39%)
		leucine-rich repeat	465..496	CDD:275381	5/30 (17%)
		leucine-rich repeat	497..521	CDD:275381	8/23 (35%)
		leucine-rich repeat	522..547	CDD:275381	3/24 (13%)
		leucine-rich repeat	548..573	CDD:275381	7/26 (27%)
		leucine-rich repeat	574..599	CDD:275381	5/11 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457994
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930