DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5003 and fbxl3a

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_001005773.3	Gene:	fbxl3a / 378451	ZFINID:	ZDB-GENE-030912-5	Length:	431	Species:	Danio rerio

Alignment Length:	305	Identity:	61/305 - (20%)
Similarity:	109/305 - (35%)	Gaps:	95/305 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 KREKEHKESLDRETECNLMDFCDELLFEIFQYLDTSSILAVMHCSPRFENLLLDHRFYHHIDLSN 116
            ||.|:..|... :.:.|.:....|:|..|||||.                 |||..|
Zfish    24 KRPKQPSEDFG-DLQSNWVRLPQEILLHIFQYLP-----------------LLDRAF-------- 62

  Fly   117 GPLPMGILEEILGRATEKTHTIKICGPPSSQHVAGEFRQF--------TQTLSSVFP----RVVQ 169
                          |::..|...     .:.|:...:|.|        |..|.:..|    ::::
Zfish    63 --------------ASQVCHNWN-----HAFHMPELWRCFEFELNQPATSYLKATHPDLIKQIIK 108

  Fly   170 LKVLELEGVSLDFEYIHITEFPATLRRL--KLKDCSVR-VG----------DTPKSIFYSI---- 217
            .....|:.||  |:....||...|...:  :|.:||:: :|          :.|||.|.|.
Zfish   109 RHSNHLQYVS--FKVDSSTESAETACDILSQLVNCSLKTLGLISTARPSFMELPKSHFISALTVV 171

  Fly   218 -----ELHLLDLEDLSIEDNSWFEPYYIMGLSKLPSLRRLSLKGCQALCKFVPYGSMAARFGFQK 277
                 .|..|.::|..::|.|    ..::..:...:|:.|.:..|..:.   |.|.:........
Zfish   172 FVNSKSLSSLKIDDTPVDDPS----LKVLVANNSDTLKLLKMSSCPHVS---PAGILCVADQCHG 229

  Fly   278 LESLDLRQTPINNSDLQCFSA-----IENLK-ELLLESP-QILHS 315
            |..|.|....:::..|...|:     :|:|: :::.|:| |..|:
Zfish   230 LRELALNYHLLSDELLLALSSEKHVHLEHLRIDVVSENPGQQFHT 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	12/45 (27%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381
fbxl3a	NP_001005773.3	F-box-like	40..81	CDD:315592	14/84 (17%)
		leucine-rich repeat	178..203	CDD:275381	5/28 (18%)
		leucine-rich repeat	204..229	CDD:275381	5/27 (19%)
		leucine-rich repeat	230..255	CDD:275381	5/24 (21%)
		leucine-rich repeat	256..291	CDD:275381	6/19 (32%)
		leucine-rich repeat	292..336	CDD:275381
		leucine-rich repeat	337..363	CDD:275381
		leucine-rich repeat	364..389	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588055
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.030