DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5003 and fbxl6

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_001296447.1	Gene:	fbxl6 / 323163	ZFINID:	ZDB-GENE-060810-162	Length:	564	Species:	Danio rerio

Alignment Length:	416	Identity:	75/416 - (18%)
Similarity:	144/416 - (34%)	Gaps:	154/416 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VQPVLPQIPTEEEPEIKQRKREKEHKESLDRETE-----------CNLMDFCDELLFEIFQYLDT 86
            ::|...|:|..|:          :.|.::|...|           |:.....|.::.::.|...:
Zfish   200 IEPGKSQLPGTEQ----------KIKNTVDWLAENRLFQLREFSLCHWKKNVDYVIQKVSQSCLS 254

  Fly    87 SSILAVMHCS----PRFENLLLDHRFYHHIDLSNGPLPM-GILE--EILGRATEK---THTIKIC 141
            ...|.:.:|:    ..|:||..|.:....|::.:..:.: |::.  |..|...:|   ||:.|
Zfish   255 LHSLKLSYCTGMTEKAFQNLGADCQSLEDINVQHSEINVDGLVSFLEAYGNQIKKIYFTHSTK-- 317

  Fly   142 GPPSSQHVAGEFRQFTQTLSSVFPR--VVQLKVLE---------------LEGVSL------DFE 183
                           :..|.|...:  ..:|::||               ::|:.:      .|.
Zfish   318 ---------------SDKLLSALSKGCCPELRLLEINTKLDGGYSQLPICIQGLQIGCPKLQTFR 367

  Fly   184 YIHITEFPATLRRLKLKDCSVRVGDTPKSIFYSIELHLLDLEDLSIEDNSWFEPYYIMG-----L 243
            .:::|..|..:|.:....|...:                 ||:|.|..:  |..:....     |
Zfish   368 LMNVTAVPKMIRNIPSSTCGFPM-----------------LEELCIATS--FHSFMTDNDLNNVL 413

  Fly   244 SKLPSLRRLSLKG-------------CQAL-CKFVPYG-------SMAARFGF----QK----LE 279
            ...|:||.|.|:|             |:.| |.:  :|       .:|::.|.    ||    |.
Zfish   414 HGSPNLRVLDLRGGSRITPTGLYALPCERLECFY--WGLYFNSNTMVASKKGIHMLAQKWSNTLR 476

  Fly   280 SLDLRQTPINNSDLQCFSAIENLKELLLESPQILHSKQAVAKKNTNGNATDEAASPQPDSLKVLS 344
            .|||...|.:..||:            :....:.||......::.|.:.|...:|    :|::|.
Zfish   477 ELDLANQPFSEEDLE------------IAMGHLAHSVGVEFFRSLNLSGTKITSS----ALRLLI 525

  Fly   345 DDEPSTSRAAMEHLRACKVAFNLDNC 370
            :..|     |:::|       ||.:|
Zfish   526 NQAP-----ALKYL-------NLSSC 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	9/49 (18%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381
fbxl6	NP_001296447.1	F-box-like	147..195	CDD:289689
		AMN1	213..396	CDD:187754	34/216 (16%)
		leucine-rich repeat	229..254	CDD:275381	3/24 (13%)
		leucine-rich repeat	255..280	CDD:275381	6/24 (25%)
		leucine-rich repeat	281..306	CDD:275381	4/24 (17%)
		leucine-rich repeat	307..334	CDD:275381	6/43 (14%)
		leucine-rich repeat	335..362	CDD:275381	3/26 (12%)
		AMN1	<391..>542	CDD:187754	40/181 (22%)
		leucine-rich repeat	391..418	CDD:275381	6/28 (21%)
		leucine-rich repeat	419..438	CDD:275381	5/18 (28%)
		leucine-rich repeat	445..473	CDD:275381	6/29 (21%)
		leucine-rich repeat	475..505	CDD:275381	9/41 (22%)
		leucine-rich repeat	506..530	CDD:275381	6/32 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588011
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930