DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5003 and Fbxl13

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_011248071.1	Gene:	Fbxl13 / 320118	MGIID:	2443416	Length:	889	Species:	Mus musculus

Alignment Length:	287	Identity:	67/287 - (23%)
Similarity:	111/287 - (38%)	Gaps:	76/287 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 NLMDFCDELLFEIFQYLDTSSILAVMHCSPRFENLLLDHRFYHHIDLSNGPLPMGILEEILGRAT 132
            ||.:.|.:|:     |||.|....:  ....|.|:........|:.:::.|.......::|....
Mouse   402 NLGNGCHKLI-----YLDLSGCTQI--SVQGFRNIASSCTGIVHLTINDMPTLTDNCVKVLVEKC 459

  Fly   133 EKTHTIKICGPPSSQHVA-GEFRQFTQTLSSVFPRVVQLKVLELEG---------VSLDFEY--- 184
            .:..::.:.|.|   |:: ..|:    .|||     ..||.:..||         .|:|..|
Mouse   460 PRISSVVLIGSP---HISDSAFK----ALSS-----CDLKKIRFEGNKRISDACFKSIDRNYPGI 512

  Fly   185 --IHITEFPA-------------TLRRLKLKDCSVRVGDTPKSIFY----SIELHLLDLEDLSIE 230
              |::.:...             .|..|.|.:| :|:||.....|:    ||.|..|:|.:.|:.
Mouse   513 NHIYMVDCKGLTDSSLKSLSLLKQLTVLNLTNC-IRIGDIGLKHFFDGPASIRLRELNLTNCSLL 576

  Fly   231 DNSWFEPYYIMGLS-KLPSLRRLSLKGCQALCKF-VPY-GSMAARFGFQKLESLDLRQTPINNSD 292
            .:|     .::.|| :.|:|..|:|:.|:.|... :.| .||.:      |.|:||..|.|:|..
Mouse   577 GDS-----SVIRLSERCPNLHYLNLRNCEHLTDLAIEYIASMLS------LISVDLSGTLISNET 630

  Fly   293 LQ----------CFSAIENLKELLLES 309
            ..          |.||:.....|.|:|
Mouse   631 SAYPSVILMASLCPSALLQHHSLHLDS 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	11/45 (24%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381
Fbxl13	XP_011248071.1	F-box-like	240..284	CDD:372399
		leucine-rich repeat	255..268	CDD:275381
		leucine-rich repeat	280..306	CDD:275381
		AMN1	306..475	CDD:187754	16/82 (20%)
		leucine-rich repeat	307..330	CDD:275381
		leucine-rich repeat	331..356	CDD:275381
		leucine-rich repeat	357..381	CDD:275381
		leucine-rich repeat	382..409	CDD:275381	3/6 (50%)
		leucine-rich repeat	410..435	CDD:275381	7/31 (23%)
		leucine-rich repeat	436..461	CDD:275381	3/24 (13%)
		leucine-rich repeat	462..484	CDD:275381	7/33 (21%)
		AMN1	473..605	CDD:187754	35/146 (24%)
		leucine-rich repeat	486..511	CDD:275381	7/24 (29%)
		leucine-rich repeat	512..536	CDD:275381	1/23 (4%)
		leucine-rich repeat	537..564	CDD:275381	9/27 (33%)
		leucine-rich repeat	565..590	CDD:275381	7/29 (24%)
		leucine-rich repeat	591..610	CDD:275381	5/18 (28%)
		leucine-rich repeat	617..645	CDD:275381	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843162
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930