DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5003 and Fbxl17

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_038939705.1	Gene:	Fbxl17 / 316663	RGDID:	1309773	Length:	739	Species:	Rattus norvegicus

Alignment Length:	411	Identity:	83/411 - (20%)
Similarity:	147/411 - (35%)	Gaps:	110/411 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EQAELGSTCLAAPKRRFPDNE-RCGRELAAVPVQPVLPQIPTEEEPEIKQRKREKEHKESLDRET 65
            :|.|.|.:....|    |:|. .|.||             |..|.|:|.|
  Rat   286 QQPESGDSDCQEP----PENPCDCHRE-------------PPPEIPDINQ--------------- 318

  Fly    66 ECNLMDFCDELLFEIFQ--YLDTSSILAVMHCSPRFENLLLDHRFYHHIDLSNGPLPMGILEEIL 128
                  ....:|.:||.  .||...:.|.:.|. .:.:|.||.:|:..:|||:   ...:.:|:|
  Rat   319 ------LPPSILLKIFSNLSLDERCLSASLVCK-YWRDLCLDFQFWKQLDLSS---RQQVTDELL 373

  Fly   129 GRATEKTHTI--------------KIC-----GPPSSQHVAGEFRQFTQT----LSSVFPRVVQL 170
            .:...::..|              .:|     .|...::.|...:|.:.|    ::|..|.:.::
  Rat   374 EKIASRSQNIVEINISDCRSMSDSGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKV 438

  Fly   171 KV-----LELEGVSLDFEYIHITEFPATLRRLK---LKDCSVRVGDTPKSIFYSIELHLLDLEDL 227
            .|     |..||         :.:..:..|.||   ...| .::.|....:   |....|.|:.:
  Rat   439 HVGNQDKLTDEG---------LKQLGSKCRELKDIHFGQC-YKISDEGMVV---IAKSCLKLQRI 490

  Fly   228 SIEDNSWFEPYYIMGLSK-LPSLRRLSLKGCQALCKFVPYGSMAARFGFQKLESLDLRQ-TPINN 290
            .:::|.......:...:: .|.|:.:...||....|.|.:.:.     .:.|.|||||. |.::|
  Rat   491 YMQENKLVTDQSVKAFAEHCPDLQCVGFMGCSVTSKGVIHLTK-----LRNLSSLDLRHITELDN 550

  Fly   291 SD-LQCFSAIENLKELLLESPQILHSK--QAVAKKNTNGNATDEAASPQPDSLKVLSDDEPSTSR 352
            .. ::.....:||..|.|....|::.:  :.:||:   |.:..|....   |.|:....:...|.
  Rat   551 ETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKE---GQSLKELYLV---SCKITDYGQRGNSG 609

  Fly   353 AA-----MEHLRACKVAFNLD 368
            ||     ..||:.|......|
  Rat   610 AAGTAVPSHHLQHCPAGLQED 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	11/47 (23%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381
Fbxl17	XP_038939705.1	F-box-like	316..361	CDD:403981	13/66 (20%)
		leucine-rich repeat	357..382	CDD:275381	5/27 (19%)
		leucine-rich repeat	383..408	CDD:275381	2/24 (8%)
		AMN1	406..568	CDD:187754	36/179 (20%)
		leucine-rich repeat	409..434	CDD:275381	4/24 (17%)
		leucine-rich repeat	435..460	CDD:275381	4/33 (12%)
		leucine-rich repeat	461..486	CDD:275381	5/28 (18%)
		leucine-rich repeat	487..512	CDD:275381	2/24 (8%)
		leucine-rich repeat	513..536	CDD:275381	5/27 (19%)
		leucine-rich repeat	537..562	CDD:275381	8/24 (33%)
		leucine-rich repeat	563..588	CDD:275381	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346638
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840