DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5003 and Fbxl12

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_001273458.1	Gene:	Fbxl12 / 30843	MGIID:	1354738	Length:	349	Species:	Mus musculus

Alignment Length:	192	Identity:	43/192 - (22%)
Similarity:	82/192 - (42%)	Gaps:	22/192 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 RFENLLLDHRFYHHIDLSNGPLPMGILEEILGR-ATEKTHTIKICGPPSSQHVAGEFRQFTQTLS 161
            |::.|:.|...:.|:||:...:...::..:|.| ...:.:::::.|...|...|.:       ||
Mouse    56 RWKRLVDDRWLWRHVDLTLYTMRPKVMWHLLRRYMASRLYSLRMGGYLFSGSQAPQ-------LS 113

  Fly   162 SVFPRVVQLKVLELEGVSL---DFEYIHITEFPATLRRLKLKDCSVRV----GDTPKSIFYSIEL 219
            ....|.:..|...|:.:.|   |...:.||..|:|||.|:|..|.:.:    .:...::...:|.
Mouse   114 PALMRALGQKCPNLKRLCLHVADLSMVPITSLPSTLRTLELHSCEISMIWLQKEQDPTVLPLLEC 178

  Fly   220 HLLDLEDLSIEDNSWFEPYYIMGLSKLPSLRRLSLKGCQALCKFVPYGSMAARFGFQKLESL 281
            .:||....       |...::.||::..:||.|.|.|...:.:.....|:......|:||.|
Mouse   179 IVLDRVPA-------FRDEHLQGLTRFRALRSLVLGGTYRVTETGLDASLQELSYLQRLEVL 233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	4/15 (27%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381
Fbxl12	NP_001273458.1	F-box-like	<51..73	CDD:289689	5/16 (31%)
		leucine-rich repeat	127..148	CDD:275381	6/20 (30%)
		AMN1	144..>249	CDD:187754	23/97 (24%)
		leucine-rich repeat	149..175	CDD:275381	5/25 (20%)
		leucine-rich repeat	176..200	CDD:275381	6/30 (20%)
		leucine-rich repeat	201..226	CDD:275381	6/24 (25%)
		leucine-rich repeat	227..252	CDD:275381	4/7 (57%)
		leucine-rich repeat	253..276	CDD:275381
		leucine-rich repeat	277..306	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1046098at2759
OrthoFinder	1	1.000	-	-		FOG0009915
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5688
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020