DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5003 and Fbxl6

DIOPT Version :9

Sequence 1:NP_651593.1 Gene:CG5003 / 43344 FlyBaseID:FBgn0039554 Length:713 Species:Drosophila melanogaster
Sequence 2:NP_038937.2 Gene:Fbxl6 / 30840 MGIID:1354705 Length:535 Species:Mus musculus


Alignment Length:385 Identity:85/385 - (22%)
Similarity:119/385 - (30%) Gaps:161/385 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 KRRFPDNERCGRELAAVPVQPVLPQIPTEEEPEIKQRKREKEHKESLDRETECNLMDFCD-ELLF 78
            :||.|      |.||..|.....|:.....||             |||:..:....|... |:|.
Mouse    68 RRRAP------RSLARGPTAVAKPRTKPRPEP-------------SLDQGLDSGWGDRIPLEVLV 113

  Fly    79 EIFQYLDTSSILAVMHCSPRFENLLLDHRFYHHIDLSNGPLPMGILEEILGRAT-------EKT- 135
            .||      .:|...|                      ||:|      .||||.       |.| 
Mouse   114 HIF------GLLVAAH----------------------GPMP------FLGRAARVCRHWHEATS 144

  Fly   136 -----HTI----KICGPPSSQHVAGEFRQFTQTLSSVFP-RVVQLKVLELEGVSLDFEYIH---- 186
                 ||:    .:.|.....::.|| ::....|..:.| |..||:.|.|         ||    
Mouse   145 HPSLWHTVTLSPSLVGRAGKGNLKGE-KKLLACLEWLVPNRFSQLQSLTL---------IHWKSQ 199

  Fly   187 -------ITEFPATLRRLKLKDCSVRVGDTPKSIFYS-IELHLLDLEDLSIEDNS---------- 233
                   :::|...|..|||.||.....:|...:..: .:||.|||....:|..:          
Mouse   200 VHSVLELVSKFCPRLTFLKLSDCHTVTAETLVMLARACCQLHSLDLHHSMVESTAVVSFLEEAGS 264

  Fly   234 -----WF----EPYYIMGL---SKLPSLRRLSL-------------------KGCQAL------- 260
                 |.    :...|:|.   :..|.|:.|.:                   |||..|       
Mouse   265 RMRKLWLTYSSQTTAILGALLDNCCPQLQVLQVSTGMNCNNTPLQLPVEALQKGCPQLQVLRLLN 329

  Fly   261 -------C-KFVPYGSMAARFGFQKLESLDLRQTPINNSDLQCFSAIENLKELLLESPQI 312
                   | :.||.|.     ||..||.|.|..:..|      |.:.|.|..||..||::
Mouse   330 LIWLPKPCGRGVPQGP-----GFPSLEELCLAGSTCN------FVSNEVLGRLLHRSPKL 378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5003NP_651593.1 F-box 68..114 CDD:279040 7/46 (15%)
leucine-rich repeat 610..635 CDD:275381
Fbxl6NP_038937.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 61..99 13/49 (27%)
F-box-like 105..155 CDD:289689 18/83 (22%)
LRR 1 169..195 9/35 (26%)
AMN1 171..390 CDD:187754 51/228 (22%)
leucine-rich repeat 188..213 CDD:275381 6/33 (18%)
LRR 2 196..221 5/24 (21%)
leucine-rich repeat 214..239 CDD:275381 7/24 (29%)
LRR 3 222..247 7/24 (29%)
leucine-rich repeat 240..291 CDD:275381 9/50 (18%)
LRR 4 273..299 5/25 (20%)
leucine-rich repeat 292..321 CDD:275381 5/28 (18%)
LRR 5 304..329 4/24 (17%)
leucine-rich repeat 322..349 CDD:275381 7/31 (23%)
LRR 6 330..357 10/31 (32%)
AMN1 <349..500 CDD:187754 12/36 (33%)
leucine-rich repeat 350..377 CDD:275381 11/32 (34%)
LRR 7 360..385 8/25 (32%)
leucine-rich repeat 378..401 CDD:275381 0/1 (0%)
LRR 8 386..411
LRR 9 415..441
leucine-rich repeat 434..466 CDD:275381
leucine-rich repeat 467..491 CDD:275381
LRR 10 474..499
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167843072
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR16134
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.030

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