DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5003 and Fbxl3

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_001094038.1	Gene:	Fbxl3 / 306129	RGDID:	1305660	Length:	428	Species:	Rattus norvegicus

Alignment Length:	308	Identity:	49/308 - (15%)
Similarity:	110/308 - (35%)	Gaps:	85/308 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 EEEPEIKQRKREKEHKESLDRETECNLMDFCDELLFEIFQYLDTSSILAVMHCSPRFENLLLDHR 107
            ::.||....::.|:.:.:.:....|:..:...:::..:|:||.                 |||
  Rat    10 QDSPEEGTAEKPKKPRTTHECSQPCDWGNLLQDIVLHVFKYLP-----------------LLD-- 55

  Fly   108 FYHHIDLSNGPLPMGILEEILGRATEKTHTIKICGPPSSQ-HVAGEFRQF--------TQTLSSV 163
                                      :.|..::|...:.. |:...:|.|        |..|.:.
  Rat    56 --------------------------RAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKAT 94

  Fly   164 FPRVVQLKVLELEGVSLDFEYIHITEFPATLRRL-----KLKDCSVR-VG----------DTPKS 212
            .|.::: ::::.....|.:....:.....:....     :|.:||:: :|          |.|||
  Rat    95 HPELIK-QIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKS 158

  Fly   213 IFYS----IELHLLDLEDLSIEDNSWFEP-YYIMGLSKLPSLRRLSLKGCQALCKFVPYGSMAAR 272
            .|.|    :.::...|..|.|:|....:| ..::..:...:|:.|.:..|..:.   |.|.:...
  Rat   159 HFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVS---PAGILCVA 220

  Fly   273 FGFQKLESLDLRQTPINNSDLQCFSA-----IENLK-ELLLESPQILH 314
            .....|..|.|....:::..|...|:     :|:|: :::.|:|...|
  Rat   221 DQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTH 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	6/45 (13%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381
Fbxl3	NP_001094038.1	F-box-like	36..77	CDD:403981	9/85 (11%)
		leucine-rich repeat	174..199	CDD:275381	5/24 (21%)
		leucine-rich repeat	200..225	CDD:275381	5/27 (19%)
		leucine-rich repeat	252..286	CDD:275381	5/17 (29%)
		leucine-rich repeat	287..333	CDD:275381
		leucine-rich repeat	334..360	CDD:275381
		leucine-rich repeat	361..383	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346633
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030