DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5003 and Fbxl5

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_006251138.1	Gene:	Fbxl5 / 305424	RGDID:	1306887	Length:	690	Species:	Rattus norvegicus

Alignment Length:	476	Identity:	95/476 - (19%)
Similarity:	157/476 - (32%)	Gaps:	188/476 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QPVLPQIPTEEE-PEIKQR-------------------------KREKEHKESLDRETEC----- 67
            ||:|.:..|.|| .:||::                         :|:|..|.|:|.:::.
  Rat   135 QPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNQAEERQKVFKYSVDEKSDAEAEVS 199

  Fly    68 ----NLMDFCDELLFEIFQYLDTSSILAVMHCSPRFENLLLDHRFYHHI--------DLSNGPLP 120
                .:.....|::..||.||:...:......|.::..|......:.|:        |..:||
  Rat   200 EHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSTKWSQLAKTGSLWKHLYPVHWARGDWYSGP-- 262

  Fly   121 MGILEEILGRATEKTHTIKICGPPSSQHVAG---EFRQFTQ-------------TLSSVFPRVVQ 169
                      |||      :...|..:.|..   |.|.|.:             ...||...:.|
  Rat   263 ----------ATE------LDTEPDEEWVRSRKDESRAFQEWDEDADIDESEESAEESVAISIAQ 311

  Fly   170 LKVLELEGVSLDFEYIH-ITEFPATLRRLKLKDCSVRVGDTPKSIFYSIEL-----HLLDLEDLS 228
            ::...|.|:      || :..:..|..:..:...|..|  :.|.:...:||     | |||....
  Rat   312 MEKRLLHGL------IHNVLPYVGTSVKTLVLAYSSAV--SSKMVRQILELCPNLEH-LDLTQTD 367

  Fly   229 IEDNSWFEPYYIMGLSKLPSLRRLSLKGCQALCKFVPYGSMAARFGFQKLESLDLRQTPINNSDL 293
            |.|:: |:.:..:|..:  |||.|.|.||:.:                              :|:
  Rat   368 ISDSA-FDSWSWLGCCQ--SLRHLDLSGCEKI------------------------------TDM 399

  Fly   294 QCFSAIENLKELLLESPQILHSKQAVAKKNTNGNATDEAASPQPDSLKVLSDDEPSTSRAAMEHL 358
                |:|.:...|    .:|.|.|:...|:. |..|....:.:..::       |||::.|..|
  Rat   400 ----ALEKISRAL----GVLTSHQSGVLKSA-GKTTSTPWTNKDITM-------PSTTQYACLH- 447

  Fly   359 RACKVAFNLDNCSDRKEEKS------PVPTE---PP----SEGQDLQAKRIRAPSESDDED---- 406
                   ||.|....:|..|      ||.:|   ||    .:.:||          :|.||
  Rat   448 -------NLTNKGVGEEIDSEHTWTEPVSSESFTPPYVWMLDAEDL----------ADIEDAVEW 495

  Fly   407 ------------TSSTSGSSS 415
                        |:|..|.||
  Rat   496 RHRNVESLCVMETASNFGCSS 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	8/53 (15%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381
Fbxl5	XP_006251138.1	Hr_FBXL5	7..160	CDD:213984	8/24 (33%)
		F-box-like	205..249	CDD:289689	8/43 (19%)
		leucine-rich repeat	332..345	CDD:275381	2/14 (14%)
		AMN1	<340..>404	CDD:187754	23/103 (22%)
		leucine-rich repeat	358..384	CDD:275381	8/29 (28%)
		leucine-rich repeat	385..448	CDD:275381	21/116 (18%)
		leucine-rich repeat	449..516	CDD:275381	17/76 (22%)
		leucine-rich repeat	540..571	CDD:275381
		leucine-rich repeat	573..626	CDD:275381
		AMN1	<602..>653	CDD:187754
		leucine-rich repeat	627..652	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346653
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930