DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5003 and Fbxw8

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_001100615.2	Gene:	Fbxw8 / 304522	RGDID:	1306032	Length:	596	Species:	Rattus norvegicus

Alignment Length:	478	Identity:	93/478 - (19%)
Similarity:	157/478 - (32%)	Gaps:	135/478 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QAELGSTCLAAPKRRFPDNERCGRELAA----VPV---------------QPVLPQIPTEEEPEI 48
            |.||..:.....:||....||..|...|    .|.               :|..|:....:..::
  Rat    14 QEELAQSQALRRRRRLEAGERRPRRPEAGARGEPASGYLGLAQGLLEGAGRPPAPRPGRTDRKDV 78

  Fly    49 KQRKREKEHKESLDRE-------TECNLMD---FCD-----ELLFEIFQYLDTSSILAVMHCSPR 98
            ..|.|....:::.:.|       .:.|.||   |.|     ||...|||||:...:......|..
  Rat    79 SSRSRSPPDRDAAEPEPLVDQLIRDLNEMDDVPFFDVHLPYELAINIFQYLNRRELGLCAQVSKT 143

  Fly    99 FENLLLDHRFYHHIDLSNGPLPMG----------ILEEIL--------------GRATEKTHT-- 137
            ::.:..|...::.:....|.||..          ||:|.|              |..:|..|.
  Rat   144 WKVIAEDEVLWYRLCRQEGHLPHSRFSDYTCWKLILQECLAREHKLRANWKNRKGAVSELEHVPD 208

  Fly   138 IKIC------GPPSSQHVAGEFRQF-TQTLSSVFPRVVQLKVLELEGVSLD---FEYIHITEFPA 192
            ..:|      |...:.:.:||.|.: |:|...|.|      .||.|....|   ..|:......:
  Rat   209 AVLCDVRSHDGVVIAGYTSGEVRVWDTRTWDYVAP------FLESESEEEDPGMQPYVSFVRINS 267

  Fly   193 TLRRLKLKDCSVRVGD--TPKSIFYSIELHLLDLEDLSI---------------------EDNSW 234
            :|.....:|..:.|.|  |.:...:..| |...::.|::                     |:.:|
  Rat   268 SLAVAAYEDGILNVWDLRTGRFPIFRFE-HDARIQALALSQEKPVVATASAFDVVMLYPNEEGNW 331

  Fly   235 -----FEPYYIMG-LSKLPSLRRLSLKGCQALCKFVPYGSMAARFGFQKLESLDLRQT------- 286
                 ||...::. |..:|:..|            .|.....|......|::.|..:|
  Rat   332 HVASEFEVQKLVDYLEIVPNTGR------------YPVAIATAGDLVYLLKAEDSARTLHYVYGQ 384

  Fly   287 PINNSDLQCFSAIENLKEL--LLESPQI----LHSKQAVAK-KNTNGNATDEAASPQPDSLKVLS 344
            |....|:........:|.|  :.|..:|    |.:::.::| .|..|:.|.......|.:|.|..
  Rat   385 PATCLDVSASQVAFGVKSLGWVYEGNKILVYSLEAERCLSKLGNALGDFTCVNIRDSPPNLMVSG 449

  Fly   345 DDEPSTSRAAMEHLRACKVAFNL 367
            :.:   .|..:..||..|:|.:|
  Rat   450 NMD---RRVRLHDLRTDKIALSL 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	14/53 (26%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381
Fbxw8	NP_001100615.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..95		11/73 (15%)
		F-box-like	116..158	CDD:403981	9/41 (22%)
		WD40	186..568	CDD:225201	57/306 (19%)
		WD 1	195..243		11/47 (23%)
		WD 2	251..292		7/40 (18%)
		WD40 repeat	256..295	CDD:293791	6/38 (16%)
		WD 3	295..334		5/39 (13%)
		WD40 repeat	300..347	CDD:293791	5/46 (11%)
		WD40 repeat	355..418	CDD:293791	11/62 (18%)
		WD40 repeat	421..470	CDD:293791	13/52 (25%)
		WD 4	428..468		11/42 (26%)
		WD 5	471..508
		WD40 repeat	476..500	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1046098at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010