DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5003 and FBXL22

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_011519770.1	Gene:	FBXL22 / 283807	HGNCID:	27537	Length:	260	Species:	Homo sapiens

Alignment Length:	366	Identity:	76/366 - (20%)
Similarity:	115/366 - (31%)	Gaps:	139/366 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 PSTSRAAM----EHLRACKVAFNLDNCSDRKEEKSPVPTEPPSEGQDLQAKRIRAPSESDDEDTS 408
            |:..|..|    .||:..|..|             |:.:....:|..|:|:..::||      |:
Human     6 PTALRVGMGLSLGHLQGNKSLF-------------PLTSRRDIQGPQLEARLEQSPS------TA 51

  Fly   409 STSGSSS-DKLEVLSLPR-NGHSNAAPLSGGVDLPPLPHAADAANAADAPIAVDAANIEAPGQSP 471
            ...||:| .|..|..... |.||          |.|.| ..|:|                 |...
Human    52 PLQGSTSRAKQRVKGCGSWNRHS----------LCPQP-PQDSA-----------------GPGS 88

  Fly   472 GLDPRPPRAYIYVPDAENANPRQQRSVVAVFAQGTEQRYIYVNQQFSLPMNVLMPTRRHRTHPRP 536
            ||..|..:.|         .||.......|..:|.::|   .|.          |.|      :|
Human    89 GLPTRGSQGY---------EPRTHADEGTVGCRGRKRR---ENG----------PAR------KP 125

  Fly   537 NYDQVV--QHPMFWNMLEPLDRDYARRVRPRPPSCQTTPQY------YVTDRAMYSFGRADRPVQ 593
            .::..|  |..:|.:.            .|.||.|......      :|||..:
Human   126 TWNPAVSSQPSVFTSQ------------GPSPPRCPNLASVTLSGCGHVTDDCL----------- 167

  Fly   594 PDVVWIRNINRSPDNKLERLSLRNYHLITNHTLEHLVQCSPNL--VYIDVSGTSITLPAIRRFKI 656
                 .|.:...|  :|..|.|.|...:||.||..:......|  :::|.. .:::...:||.:.
Human   168 -----ARLLRCCP--RLRALRLENCARVTNRTLAAVAADGRALQTLHVDFC-RNVSAAGLRRLRA 224

  Fly   657 SKPKCEVVANHLEEFERLPELETQEEDDTVVVMLQPP-PRA 696
            :.|:..:.|.|  ....||:              ||| |||
Human   225 ACPRLALRAEH--SAAMLPD--------------QPPRPRA 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381	8/24 (33%)
FBXL22	XP_011519770.1	AMN1	<148..229	CDD:187754	19/99 (19%)
		leucine-rich repeat	151..176	CDD:275381	5/42 (12%)
		leucine-rich repeat	177..202	CDD:275381	8/24 (33%)
		leucine-rich repeat	203..228	CDD:275381	4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153001
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030