DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5003 and Skp2

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_011243661.1	Gene:	Skp2 / 27401	MGIID:	1351663	Length:	434	Species:	Mus musculus

Alignment Length:	386	Identity:	79/386 - (20%)
Similarity:	119/386 - (30%)	Gaps:	120/386 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PQIPTEEEPEIKQRKREKE----HKESLDRETECNLM--DFCDELLFEIFQYLDTSSILAVMHCS 96
            ||.|..:  .:|.:..:|:    .:..|.||....:.  ...||||..||..|....:|.|....
Mouse    72 PQSPPRK--RVKGKGSDKDFVIIRRPKLSRENFPGVSWDSLPDELLLGIFSCLCLPELLRVSGVC 134

  Fly    97 PRFENLLLDHRFYHHIDLSNGPLPMGILEEILGRATEKTHTIKICGPPS--SQHVAGEFRQF--- 156
            .|:..|.||...:..:||:...|...:...:|.|.     .:....|.|  .|.:...|..|
Mouse   135 KRWYRLSLDESLWQSLDLAGKNLHPDVTVRLLSRG-----VVAFRCPRSFMEQPLGESFSSFRVQ 194

  Fly   157 ----------TQTLSSVFPRVVQLKVLELEGVSLDFEYIHITEFPATLRRLKLKDCS-------- 203
                      ...|..:.....:|:.|.|||:.|....:........|.||.|..||
Mouse   195 HMDLSNSVINVSNLHKILSECSKLQNLSLEGLQLSDPIVKTLAQNENLVRLNLCGCSGFSESAVA 259

  Fly   204 --------------------------VRVGDTPKSIFYSIELHL--------------------- 221
                                      ..|...|.:|   .:|:|
Mouse   260 TLLSSCSRLDELNLSWCFDFTEKHVQAAVAHLPNTI---TQLNLSGYRKNLQKTDLCTIIKRCPN 321

  Fly   222 ---LDLEDLSIEDNSWFEPYYIMGLSKLPSLRRLSLKGCQALCKFVPYGSMAARFGFQKLESLDL 283
               |||.|..:..|..|..::     :|..|:.|||..|..:   :|.            ..|:|
Mouse   322 LIRLDLSDSIMLKNDCFPEFF-----QLNYLQHLSLSRCYDI---IPD------------TLLEL 366

  Fly   284 RQTPINNSDLQCFSAI-ENLKELLLESPQILHSKQAVAKKNTNGNATDEAASPQPDSLKVL 343
            .:.|...: ||.|..: |...:||         ::|:.:...|.......|.|..||.|.|
Mouse   367 GEIPTLKT-LQVFGIVPEGTLQLL---------REALPRLQINCAYFTTIARPTMDSKKNL 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	13/47 (28%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381
Skp2	XP_011243661.1	F-box-like	107..151	CDD:372399	13/43 (30%)
		leucine-rich repeat	147..177	CDD:275381	5/34 (15%)
		leucine-rich repeat	193..217	CDD:275381	1/23 (4%)
		AMN1	203..>355	CDD:187754	29/159 (18%)
		leucine-rich repeat	218..241	CDD:275381	6/22 (27%)
		leucine-rich repeat	242..267	CDD:275381	6/24 (25%)
		leucine-rich repeat	268..293	CDD:275381	1/24 (4%)
		leucine-rich repeat	295..321	CDD:275381	3/28 (11%)
		leucine-rich repeat	322..346	CDD:275381	7/28 (25%)
		leucine-rich repeat	347..366	CDD:275381	7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843086
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940