DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5003 and FBXW8

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_016874665.1	Gene:	FBXW8 / 26259	HGNCID:	13597	Length:	599	Species:	Homo sapiens

Alignment Length:	389	Identity:	78/389 - (20%)
Similarity:	130/389 - (33%)	Gaps:	108/389 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 ETECNLMDFCD-----ELLFEIFQYLDTSSILAVMHCSPRFENLLLDHRFYHHIDLSNGPLPMGI 123
            |.|.|.:.|.|     ||...||||||...:......|..::.:..|...::.:....|.||...
Human   107 ENEMNDVPFFDIQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRLCQQEGHLPDSS 171

  Fly   124 LEE------ILGRATEKTHTIK--------------------IC------GPPSSQHVAGEFRQF 156
            :.:      |......|.|.::                    :|      |...:.:.:|:.|.:
Human   172 ISDYSCWKLIFQECRAKEHMLRTNWKNRKGAVSELEHVPDTVLCDVHSHDGVVIAGYTSGDVRVW 236

  Fly   157 -TQTLSSVFPRVVQLKVLELE------GVSLDFEYIHITEFPATLRR----LKLKDCSVRVGDTP 210
             |:|...|.|      .||.|      |:..:..::.|....|....    |.:.|  :|.|..|
Human   237 DTRTWDYVAP------FLESEDEEDEPGMQPNVSFVRINSSLAVAAYEDGFLNIWD--LRTGKYP 293

  Fly   211 KSIF---YSIELHLLDLEDLSI--------------EDNSW-----FE-PYYIMGLSKLPSLRRL 252
            ...|   ..|:...|..:|.::              |:..|     || |..:..|..:|..||
Human   294 VHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETRR- 357

  Fly   253 SLKGCQALCKFVPYGSMAARFGFQKLESLDLRQT-------PINNSDL---QCFSAIENLKELLL 307
                       .|....||......|::.|..:|       |:...|:   |....::.|..:..
Human   358 -----------YPVAVAAAGDLMYLLKAEDSARTLLYAHGPPVTCLDVSANQVAFGVQGLGWVYE 411

  Fly   308 ESPQILHSKQAVAKKNTNGNA----TDEAASPQPDSLKVLSDDEPSTSRAAMEHLRACKVAFNL 367
            .|..:::|.:|..:....||.    |....|..|.:|.|..:.:   .|..:..||:..:|.:|
Human   412 GSKILVYSLEAGRRLLKLGNVLRDFTCVNLSDSPPNLMVSGNMD---GRVRIHDLRSGNIALSL 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	13/50 (26%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381
FBXW8	XP_016874665.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1046098at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010