DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5003 and FBXL5

DIOPT Version :9

Sequence 1:NP_651593.1 Gene:CG5003 / 43344 FlyBaseID:FBgn0039554 Length:713 Species:Drosophila melanogaster
Sequence 2:NP_036293.1 Gene:FBXL5 / 26234 HGNCID:13602 Length:691 Species:Homo sapiens


Alignment Length:571 Identity:112/571 - (19%)
Similarity:183/571 - (32%) Gaps:203/571 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 QPVLPQIPTEEE-PEIKQR-------------------------KREKEHKESLDRETE------ 66
            ||:|.:..|.|| .:||::                         :|:|..|.|:|.:::      
Human   135 QPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVS 199

  Fly    67 ---CNLMDFCDELLFEIFQYLDTSSILAVMHCSPRFENLLLDHRFYHHI--------DLSNGPLP 120
               ..:.....|::..||.||:...:......|.::..|......:.|:        |..:||  
Human   200 EHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGP-- 262

  Fly   121 MGILEEILGRATEKTHTIKICGPPSSQHVAG---EFRQFTQ-------------TLSSVFPRVVQ 169
                      |||      :...|..:.|..   |.|.|.:             ...|:...:.|
Human   263 ----------ATE------LDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQ 311

  Fly   170 LKVLELEGVSLDFEYIH-ITEFPATLRRLKLKDCSVRVGDTPKSIFYSIEL-----HLLDLEDLS 228
            ::...|.|:      || :..:..|..:..:...|..|  :.|.:...:||     | |||....
Human   312 MEKRLLHGL------IHNVLPYVGTSVKTLVLAYSSAV--SSKMVRQILELCPNLEH-LDLTQTD 367

  Fly   229 IEDNSWFEPYYIMGLSKLPSLRRLSLKGCQALCKFV------PYGSMAA-RFGFQKLESLDLRQT 286
            |.|:: |:.:..:|..:  |||.|.|.||:.:....      ..|.:.: :.||.|..:..:..|
Human   368 ISDSA-FDSWSWLGCCQ--SLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKITST 429

  Fly   287 PINNSDLQCFSAIENLKELLLESPQILHSKQAVAKKNTNGNATDEAASPQPDSLKVLS------- 344
            ...|.|:    .:::.|:.     ..||..       ||....:|..:..|.:..|.|       
Human   430 AWKNKDI----TMQSTKQY-----ACLHDL-------TNKGIGEEIDNEHPWTKPVSSENFTSPY 478

  Fly   345 ------------DDEPSTSRAAMEHLRACKVAFNLDNCSD-----------------RKEEKSP- 379
                        :|........:|.|...:.|.|. :||.                 ::...|| 
Human   479 VWMLDAEDLADIEDTVEWRHRNVESLCVMETASNF-SCSTSGCFSKDIVGLRTSVCWQQHCASPA 542

  Fly   380 -----------------VPTEPPSEGQDLQAKRIRAP---------SESDDEDTS------STSG 412
                             :.:.|.|.....:|.|.|.|         ||..|::|.      |.||
Human   543 FAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSG 607

  Fly   413 S---SSDKLEVLS----LPRNGHSNAAPLSG-----GVDLPPLPHAADAAN 451
            .   :...|.||:    ||...|.|   |||     |..|..|..|..:.|
Human   608 CYQITDHGLRVLTLGGGLPYLEHLN---LSGCLTITGAGLQDLVSACPSLN 655

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5003NP_651593.1 F-box 68..114 CDD:279040 8/53 (15%)
leucine-rich repeat 610..635 CDD:275381
FBXL5NP_036293.1 Hemerythrin-like 1..159 8/23 (35%)
Hr_FBXL5 7..160 CDD:213984 8/24 (33%)
F-box-like 205..249 CDD:289689 8/43 (19%)
leucine-rich repeat 332..357 CDD:275381 5/26 (19%)
LRR 1 340..364 8/26 (31%)
AMN1 354..>408 CDD:187754 16/57 (28%)
leucine-rich repeat 358..384 CDD:275381 8/29 (28%)
LRR 2 365..392 9/29 (31%)
leucine-rich repeat 385..435 CDD:275381 12/49 (24%)
LRR 3 393..418 2/24 (8%)
leucine-rich repeat 436..500 CDD:275381 10/79 (13%)
LRR 4 479..508 3/28 (11%)
leucine-rich repeat 501..537 CDD:275381 6/36 (17%)
leucine-rich repeat 538..583 CDD:275381 8/44 (18%)
LRR 5 576..607 7/30 (23%)
leucine-rich repeat 584..627 CDD:275381 11/42 (26%)
AMN1 <603..>654 CDD:187754 17/53 (32%)
LRR 6 608..635 8/29 (28%)
leucine-rich repeat 628..653 CDD:275381 9/27 (33%)
LRR 7 636..661 5/20 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165153053
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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