DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5003 and FBXL6

DIOPT Version :9

Sequence 1:NP_651593.1 Gene:CG5003 / 43344 FlyBaseID:FBgn0039554 Length:713 Species:Drosophila melanogaster
Sequence 2:NP_036294.2 Gene:FBXL6 / 26233 HGNCID:13603 Length:539 Species:Homo sapiens


Alignment Length:338 Identity:69/338 - (20%)
Similarity:115/338 - (34%) Gaps:84/338 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   384 PPSEGQDLQAKRIRAPSESDD--EDTSSTSGS------SSDKLEVLSLPRNGHSNAAPLSGGVDL 440
            |.|.....:|:....|..::|  .|..:..||      |...|.|||.|......|...:.....
Human     4 PASRQVRRRARAAPRPRSAEDWWWDRLAPRGSGYHLLQSDSMLLVLSEPGPARPRAQRRASRRTP 68

  Fly   441 PPLPHAADAANAADAPIAVDAANIEAPGQSPGLDPRPPRAYIYVPDAENANPRQQRSVVAVF--- 502
            ...|....||....|.:..:||  .||..:|...|.|...    |||...:......:|.:|   
Human    69 RQPPRGPSAAAKPKAGLRSEAA--AAPAPAPAPTPTPEEG----PDAGWGDRIPLEILVQIFGLL 127

  Fly   503 --AQGTEQRYIYVNQQFSLPMNVLMPTRRHRTHPRPNYDQVVQHPMFWN---MLEPLDRDYARRV 562
              |.|              ||..|  .|..|...|  :.:....|..|:   :..||        
Human   128 VAADG--------------PMPFL--GRAARVCRR--WQEAASQPALWHTVTLSSPL-------- 166

  Fly   563 RPRPPSCQTTPQYYVTDRAMYSFGRADRPVQPDVVWIRNINRSPDNKLERLSLRNYHLITNHTLE 627
                           ..|......:|::.:...:.|:.. ||.  ::|:||:|.::....:..|:
Human   167 ---------------VGRPAKGGVKAEKKLLASLEWLMP-NRF--SQLQRLTLIHWKSQVHPVLK 213

  Fly   628 HLVQCSPNLVYIDVSGT-SITLPAIRRFKISKPKCEV--------------VANHLEEF-ERLPE 676
            .:.:|.|.|.::.:||. .:|..|:  ..::|..|::              |.:.|||. .|:.:
Human   214 LVGECCPRLTFLKLSGCHGVTADAL--VMLAKACCQLHSLDLQHSMVESTAVVSFLEEAGSRMRK 276

  Fly   677 LETQEEDDTVVVM 689
            |.......|..::
Human   277 LWLTYSSQTTAIL 289

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5003NP_651593.1 F-box 68..114 CDD:279040
leucine-rich repeat 610..635 CDD:275381 6/24 (25%)
FBXL6NP_036294.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 49..111 18/67 (27%)
F-box-like 113..163 CDD:289689 12/67 (18%)
LRR 1 177..203 8/28 (29%)
AMN1 185..398 CDD:187754 24/110 (22%)
leucine-rich repeat 196..221 CDD:275381 6/24 (25%)
LRR 2 204..229 4/24 (17%)
leucine-rich repeat 222..247 CDD:275381 6/26 (23%)
LRR 3 230..255 4/26 (15%)
leucine-rich repeat 248..299 CDD:275381 7/42 (17%)
LRR 4 281..307 1/9 (11%)
leucine-rich repeat 300..329 CDD:275381
LRR 5 312..337
leucine-rich repeat 330..357 CDD:275381
LRR 6 341..365
AMN1 <357..508 CDD:187754
leucine-rich repeat 358..385 CDD:275381
LRR 7 368..393
leucine-rich repeat 386..409 CDD:275381
LRR 8 394..419
LRR 9 423..449
leucine-rich repeat 442..474 CDD:275381
LRR 10 453..481
leucine-rich repeat 475..499 CDD:275381
LRR 11 482..507
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152987
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR16134
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.030

Return to query results.
Submit another query.