DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5003 and FBXL3

DIOPT Version :9

Sequence 1:NP_651593.1 Gene:CG5003 / 43344 FlyBaseID:FBgn0039554 Length:713 Species:Drosophila melanogaster
Sequence 2:NP_036290.1 Gene:FBXL3 / 26224 HGNCID:13599 Length:428 Species:Homo sapiens


Alignment Length:302 Identity:49/302 - (16%)
Similarity:107/302 - (35%) Gaps:91/302 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 KQRKREKEHKESLDRETECNLMDFCDELLFEIFQYLDTSSILAVMHCSPRFENLLLDHRFYHHID 113
            |:.:...||.::      |:..:...:::.::|:||.                 |||        
Human    22 KKLRTTNEHSQT------CDWGNLLQDIILQVFKYLP-----------------LLD-------- 55

  Fly   114 LSNGPLPMGILEEILGRATEKTHTIKICGPPSSQ-HVAGEFRQF--------TQTLSSVFPRVVQ 169
                                :.|..::|...:.. |:...:|.|        |..|.:..|.:::
Human    56 --------------------RAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIK 100

  Fly   170 LKVLELEGVSLDFEYIHITEFPATLRRL-----KLKDCSVR-VG----------DTPKSIFYS-- 216
             ::::.....|.:....:.....:....     :|.:||:: :|          |.|||.|.|  
Human   101 -QIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISAL 164

  Fly   217 --IELHLLDLEDLSIEDNSWFEP-YYIMGLSKLPSLRRLSLKGCQALCKFVPYGSMAARFGFQKL 278
              :.::...|..|.|:|....:| ..::..:...:|:.|.:..|..:.   |.|.:........|
Human   165 TVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVS---PAGILCVADQCHGL 226

  Fly   279 ESLDLRQTPINNSDLQCFSA-----IENLK-ELLLESPQILH 314
            ..|.|....:::..|...|:     :|:|: :::.|:|...|
Human   227 RELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTH 268

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5003NP_651593.1 F-box 68..114 CDD:279040 6/45 (13%)
leucine-rich repeat 610..635 CDD:275381
FBXL3NP_036290.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27 1/4 (25%)
F-box-like 36..77 CDD:403981 9/85 (11%)
LRR 1 119..146 4/26 (15%)
leucine-rich repeat 174..199 CDD:275381 5/24 (21%)
LRR 2 181..207 4/25 (16%)
leucine-rich repeat 200..225 CDD:275381 5/27 (19%)
LRR 3 208..233 6/27 (22%)
LRR 4 234..259 4/24 (17%)
leucine-rich repeat 252..286 CDD:275381 5/17 (29%)
leucine-rich repeat 287..333 CDD:275381
LRR 5 316..341
leucine-rich repeat 334..360 CDD:275381
LRR 6 343..368
leucine-rich repeat 361..383 CDD:275381
LRR 7 369..394
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165153033
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR16134
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.030

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