DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5003 and FBXL2

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_001336245.1	Gene:	FBXL2 / 25827	HGNCID:	13598	Length:	454	Species:	Homo sapiens

Alignment Length:	619	Identity:	120/619 - (19%)
Similarity:	184/619 - (29%)	Gaps:	235/619 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 ELLFEIFQYLDTSSILAVMHCSPRFENLLLDHRFYHHIDLSNGPLPMGILEEILGRATEKTHTIK 139
            |||..||.:||..::......|..:..|.||...:..|||.|      ...::.||..|  :..|
Human    18 ELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFN------FQTDVEGRVVE--NISK 74

  Fly   140 ICGPPSSQHVAGEFRQFTQTLSSVFPRVVQLKVLELEGVSLDFEYIHITEFPATLRRLKLKDCSV 204
            .||                                                 ..||:|.|:.| :
Human    75 RCG-------------------------------------------------GFLRKLSLRGC-I 89

  Fly   205 RVGDTPKSIFYSIELHLLDLEDLSIEDNSWFEPYYIMGLSKLPSLRRLSLKGCQALCKFVPYGSM 269
            .|||:....|                            .....::..|:|.||..:.....|.
Human    90 GVGDSSLKTF----------------------------AQNCRNIEHLNLNGCTKITDSTCYS-- 124

  Fly   270 AARFGFQKLESLDLRQ-TPINNSDLQCFS-AIENLKELLLE-SPQILHSKQAVAKKNTNGNATDE 331
            .:|| ..||:.|||.. ..|.||.|:..| ...||:.|.|. ..||  :|..:           |
Human   125 LSRF-CSKLKHLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQI--TKDGI-----------E 175

  Fly   332 AASPQPDSLKVL-------SDDEPSTSRAAMEHLR-ACK--VAFNLDNCSDRKEEKSPVPTEPPS 386
            |.......||.|       .:||      |::|:: .|.  |:.||.:||           ....
Human   176 ALVRGCRGLKALLLRGCTQLEDE------ALKHIQNYCHELVSLNLQSCS-----------RITD 223

  Fly   387 EG--------QDLQAKRIRAPSESDDEDTSSTSGSSSDKLEVLSLPRNGHSNAAPLSGGVDLPPL 443
            ||        ..|||..:...|...|...::. |.:..:|::|...|..|...|   |...|...
Human   224 EGVVQICRGCHRLQALCLSGCSNLTDASLTAL-GLNCPRLQILEAARCSHLTDA---GFTLLARN 284

  Fly   444 PHAADAANAADAPIAVDAANIEAPGQSPGLDPRPPRAYIYVPDAENANPRQQRSVVAVFAQGTEQ 508
            .|..:..:..:..:..|:..|:.....|.|.
Human   285 CHELEKMDLEECILITDSTLIQLSIHCPKLQ---------------------------------- 315

  Fly   509 RYIYVNQQFSLPMNVLM---PTRRHRTHPRPNYDQVVQHPMFWNMLEPLDRDYARRVRPRPPSCQ 570
              ..|:..||..:::|.   |:..::.....::.:.:.|                        |:
Human   316 --ALVSLSFSDIIHLLKMKEPSHHNKKLFGFSFCKSLSH------------------------CE 354

  Fly   571 TTPQYYVTDRAMYSFGRADRPVQPDVVWIRNINRSP--DNKLERLSLRNYHLITNHTLEHLVQCS 633
                 .:||..                 |.:::.|.  ..:|..|.|.|..|||:..||||..|.
Human   355 -----LITDDG-----------------ILHLSNSTCGHERLRVLELDNCLLITDVALEHLENCR 397

  Fly   634 --PNLVYIDVSGTSITLPAIRRFKISKPKCEVVA 665
              ..|...|..  .:|...|:|.:...|..:|.|
Human   398 GLERLELYDCQ--QVTRAGIKRMRAQLPHVKVHA 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	12/38 (32%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381	12/26 (46%)
FBXL2	NP_001336245.1	F-box-like	15..56	CDD:315592	11/37 (30%)
		leucine-rich repeat	52..79	CDD:275381	10/83 (12%)
		AMN1	<76..223	CDD:332986	50/257 (19%)
		leucine-rich repeat	80..99	CDD:275381	8/19 (42%)
		leucine-rich repeat	106..131	CDD:275381	7/27 (26%)
		leucine-rich repeat	132..157	CDD:275381	9/24 (38%)
		leucine-rich repeat	158..183	CDD:275381	8/37 (22%)
		AMN1	168..398	CDD:332986	61/345 (18%)
		leucine-rich repeat	184..209	CDD:275381	8/30 (27%)
		leucine-rich repeat	210..235	CDD:275381	7/35 (20%)
		leucine-rich repeat	236..261	CDD:275381	6/25 (24%)
		leucine-rich repeat	262..287	CDD:275381	7/27 (26%)
		leucine-rich repeat	288..313	CDD:275381	2/24 (8%)
		leucine-rich repeat	314..364	CDD:275381	11/131 (8%)
		leucine-rich repeat	374..393	CDD:275381	9/18 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153044
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1046098at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850