DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5003 and Fbxl19

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_036008913.1	Gene:	Fbxl19 / 233902	MGIID:	3039600	Length:	696	Species:	Mus musculus

Alignment Length:	447	Identity:	92/447 - (20%)
Similarity:	148/447 - (33%)	Gaps:	132/447 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 PQILHSKQAVAKKNTNGNATDEAASPQPD--SLKVLSDDEPSTSRAAMEHL-RACKVAFNLDNCS 371
            |::|:..||.:..:. |...:....|:|.  |.:..:...||..|..:|.. |.|::   |:...
Mouse   263 PRVLNPSQAFSSCHP-GLPPENWEKPKPPIASAEGPAVPSPSPQREKLERFKRMCQL---LERVP 323

  Fly   372 DRKEEKSPVPTEPPSEGQDLQAKRIRAPSESDDEDTSSTSGSSSDKLEVLSLPRNGHSNAAPLSG 436
            |.....|...::..|.|..|...  .||.|:.: ......|||.:|..     |.|.....|.:|
Mouse   324 DTSSSSSDSDSDSDSSGTSLSED--EAPGEARN-GRRPARGSSGEKEN-----RGGRRAIRPGTG 380

  Fly   437 GVDLP-PLPHAADAANAADAPIAVDAANIEAPGQSPGLDPRPPRAYIYVPDAENANPRQQRSVVA 500
            |..|. ||                          .|...||||:...:|   ....||.......
Mouse   381 GPLLSWPL--------------------------GPAPPPRPPQLERHV---VRPPPRSPEPDTL 416

  Fly   501 VFAQGTEQ-----RYIYVNQQFSLPMNVLMPTRRHRTHPRPNYDQVVQHPMFWNMLEPLDRDYAR 560
            ..|.|::.     .::.|.|... |..:.:..|..||..|..||:     ..|..:     |.:|
Mouse   417 PLAAGSDHPLPRAAWLRVFQHLG-PRELCVCMRVCRTWSRWCYDK-----RLWPRM-----DLSR 470

  Fly   561 RVRPRPPS----CQTTPQ--------------YYVTDR---------------AMYSFGRADRPV 592
            |....||.    .:..|:              .::.:|               ::.:.|.|..|.
Mouse   471 RKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPA 535

  Fly   593 QP--DVVWIRNINRS---------PDNK------------LERLSLRNYHLITNHTLEHLVQCSP 634
            ..  |:.||.::..|         ||.|            :..|.|....| |:.:|..|::.:|
Mouse   536 LRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLEL-TDASLRLLLRHAP 599

  Fly   635 NLVYIDVSGTS---------ITLPA--IRR--FKISKPKCEVVANH-LEEFERLPEL 677
            .|..:|:|..:         :|.|.  :|.  ..::...|..:.:| |..|.|.|.|
Mouse   600 QLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRL 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381	6/24 (25%)
Fbxl19	XP_036008913.1	zf-CXXC	<52..79	CDD:366873
		PHD_FXL19	89..150	CDD:277115
		F-box-like	426..467	CDD:403981	10/51 (20%)
		AMN1	468..667	CDD:187754	36/190 (19%)
		leucine-rich repeat	488..511	CDD:275381	1/22 (5%)
		leucine-rich repeat	512..535	CDD:275381	2/22 (9%)
		leucine-rich repeat	573..600	CDD:275381	6/27 (22%)
		leucine-rich repeat	601..627	CDD:275381	5/25 (20%)
		leucine-rich repeat	631..655	CDD:275381	5/23 (22%)
		leucine-rich repeat	656..680	CDD:275381	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843172
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930