DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5003 and Fbxl21

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_001333661.1	Gene:	Fbxl21 / 213311	MGIID:	2442921	Length:	460	Species:	Mus musculus

Alignment Length:	526	Identity:	97/526 - (18%)
Similarity:	161/526 - (30%)	Gaps:	187/526 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 GDTPKSIFYSI--ELHLLDLEDLSIEDNSWFEPYYIMGLSKLPSLRRLSLKGCQALCKFVPYGSM 269
            |..|..:...|  .|.|:|....|.....|.|.::|      |.|.|
Mouse    69 GTLPHHVILQIFQYLPLIDRARASSVCRRWNEVFHI------PDLWR------------------ 109

  Fly   270 AARFGFQKLESLDLRQTPINNSDLQCFSAIENLKELLLESPQILHSKQAVAKKNTNGNATDEAAS 334
              :|.|:           :|.|....|.:..         |.::   |.:.||:        ||.
Mouse   110 --KFEFE-----------LNQSATSYFKSTH---------PDLI---QQIIKKH--------AAH 141

  Fly   335 PQPDSLKVLSDDEPSTSRAAMEHLRACKVAFNLDNCSDRKEEKSPVPTEPPS------------- 386
            .|..|.||.|..|.:.:        ||.:...|.|||  .:....:.|..||
Mouse   142 LQYVSFKVDSSTESAEA--------ACDILSQLVNCS--IQTLGLISTAKPSFMNVPKSHFVSAL 196

  Fly   387 -----EGQDLQAKRIRAPSESDDEDTSSTSGSSSDKLEVLSLPRNGHSNAAPLSGGVDLPPLPHA 446
                 ..:.|.:.:|. .:..||........::||.|.:|.                 :...||.
Mouse   197 TVVFVNSKSLSSIKIE-DTPVDDPSLKILVANNSDTLRLLK-----------------MSSCPHV 243

  Fly   447 ADAANAADAPIAVDAANIEAPGQSPGLDPRPPRAYIYVPDAENANPRQQRSVVAVFAQGTEQ--- 508
            :                      |.|:                       ..||...||..:
Mouse   244 S----------------------SDGI-----------------------LCVADHCQGLRELAL 263

  Fly   509 RYIYVNQQFSLPMNVLMPTRRHRTHPRPNYDQVVQHP--MFWNMLEPLDRDYARRVRPRPPSCQT 571
            .|..::.:..|.::  ..|..:..|.|  .|.|.::|  :.::.::....|...:..||   ...
Mouse   264 NYYILSDEILLALS--SETHVNLEHLR--IDVVSENPGQIKFHSIKKRSWDALIKHSPR---VNV 321

  Fly   572 TPQYYVTDRAMYSFGRADRPVQPDVVWIRNINRSPDNKLERLSLRNYHLITNHTLEHLVQCSPNL 636
            ...:::.:....:|.:.:.|| ..:.:.|:::|:   .|.|:.|....||      .||.|:..|
Mouse   322 VMYFFLYEEEFEAFFKEETPV-THLYFGRSVSRA---ILGRIGLNCPRLI------ELVVCANGL 376

  Fly   637 VYIDVSGTSITLPAIRRFKISKPKCEVVANHLEEF-----ERLPELETQEEDDTVVVMLQPPPRA 696
            :.:|.....|.........:...:|||..:...||     .||.:|...||      :|.|
Mouse   377 LPLDSELIRIAKHCKNLTSLGLSECEVSCSAFVEFVRLCGRRLTQLSIMEE------VLVP---- 431

  Fly   697 DDEQPP 702
            ||...|
Mouse   432 DDRYTP 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381	8/24 (33%)
Fbxl21	NP_001333661.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843152
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940