DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5003 and FBXO39

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_694962.1	Gene:	FBXO39 / 162517	HGNCID:	28565	Length:	442	Species:	Homo sapiens

Alignment Length:	235	Identity:	50/235 - (21%)
Similarity:	85/235 - (36%)	Gaps:	94/235 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 QYLDTSSILAVMHCSPRFENLL----LDHRFYHHIDLSNGPLPMGILEEILGRATEKTHTIKICG 142
            |.||:.|.:       |.||::    ::..|.||:.:.|.|
Human   181 QILDSLSYM-------RNENVISELNIEDYFSHHLAVYNSP------------------------ 214

  Fly   143 PPSSQHVAGEFRQFTQTLSSVFPRVVQLKVLELEGVSLDFEYI------HITEFPATLRRLKLKD 201
                        ||.:|:|: |..:|.|        :|::..|      ::.|..:|||.:.:|
Human   215 ------------QFKKTMST-FHNLVSL--------NLNYNCISDELLENLCENASTLRTINIK- 257

  Fly   202 CSVRVGDTPKSIFYSIELHLLDLEDLSIEDNSWFE---PYYIMG---LSKLPSLRRLSLKGC--- 257
            |.|.  |....:.:.:....|..:..:::.|.:||   .|..:.   |.::| :|.:||:.|
Human   258 CHVH--DPHGQVIWGMSWAKLARQATNLKVNFFFERIMKYERLARILLQEIP-IRSISLRSCYFS 319

  Fly   258 -------QALCKFVPYGSMAARFGFQKL--------ESLD 282
                   ..|...:|    ..|...|||        ||||
Human   320 DPDCSMRPTLIDLLP----TFRHTLQKLTCEFNNNHESLD 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	10/35 (29%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381
FBXO39	NP_694962.1	F-box-like	16..57	CDD:289689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1046098at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010