DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5003 and fbxl12

DIOPT Version :9

Sequence 1:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_002933934.2	Gene:	fbxl12 / 100135148	XenbaseID:	XB-GENE-942694	Length:	350	Species:	Xenopus tropicalis

Alignment Length:	374	Identity:	81/374 - (21%)
Similarity:	137/374 - (36%)	Gaps:	84/374 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DNERCGREL-----AAVPVQPVLPQIPTEEEPEIKQRKREKEHKESLDRETECNLMDFCDELLFE 79
            |.|.||..|     .||.::..:..:|:..|            ..|:......:.:.  |.:|.|
Frog     5 DLEACGPVLTLMRKCAVSMETSMSALPSAAE------------NSSVSGTLALSWLP--DSVLLE 55

  Fly    80 IFQYLDTSSILAVMHCSPRFENLLLDHRFYHHIDLSNGPLPMGILEEIL-GRATEKTHTIKICGP 143
            :..:|....::.......|:..|::|...:.||:|:...|....|..:: .:......|:|:.|.
Frog    56 VLSFLSIRDLVRSGRVCKRWRTLVMDKTLWRHINLTPYKLDSKTLWHLVRHKFVPSLQTLKLRGT 120

  Fly   144 PSSQHVAGEFRQFTQTLSSVFPRVVQLKVLELEGVSL-DFEYIHITEFPATLRRLKLKDCSV--- 204
            ..|.. ..||.... .|..:..|...|:.|.||..:| ...|.|   ||:||:.|:|..|.:
Frog   121 LRSVK-KQEFLTMA-VLKEIESRFHNLETLHLEQTNLHSLSYCH---FPSTLKTLQLNQCELPAN 180

  Fly   205 ------RVGDT-PKSIFYSIELHLLDLEDLSIEDNSWFEPYYIMGLSKLPSLRRLS--------- 253
                  ..|.| ||            ||.|.:.....|..:::..:..|.:|:.||
Frog   181 WFKTPPNKGRTFPK------------LEHLFLNSVPSFSNHHLETICSLSALKTLSLCGTYRVTD 233

  Fly   254 ---------LKGCQAL----CKFVPYGSMAARFGFQKLESLDLRQ-TPINNSDLQCFSAIENLKE 304
                     |||.:.|    |..............:.|::|.|.. :.::::.|.|.|:::.|::
Frog   234 AGIPDSLPHLKGLEHLKLQGCYISDITLHLIGCHLKHLQTLALTDVSSVSDAGLACLSSVKTLEK 298

  Fly   305 LLLE-SPQI-LHSKQAVAKK-----------NTNGNATDEAASPQPDSL 340
            |.|| |..: |:|..||..|           ...|...||.....|:.:
Frog   299 LWLEYSTHLSLNSIIAVCGKLPALSYLHLNGTFEGRGIDELKKSLPNCM 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5003	NP_651593.1	F-box	68..114	CDD:279040	9/45 (20%)
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381
fbxl12	XP_002933934.2	F-box-like	45..88	CDD:372399	7/44 (16%)
		leucine-rich repeat	60..84	CDD:275381	4/23 (17%)
		leucine-rich repeat	85..107	CDD:275381	5/21 (24%)
		leucine-rich repeat	112..144	CDD:275381	8/33 (24%)
		leucine-rich repeat	145..194	CDD:275381	16/51 (31%)
		leucine-rich repeat	195..219	CDD:275381	5/23 (22%)
		LRR_RI	<216..343	CDD:393385	28/126 (22%)
		leucine-rich repeat	220..245	CDD:275381	4/24 (17%)
		leucine-rich repeat	246..270	CDD:275381	2/23 (9%)
		leucine-rich repeat	271..295	CDD:275381	6/23 (26%)
		leucine-rich repeat	296..321	CDD:275381	10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1046098at2759
OrthoFinder	1	1.000	-	-		FOG0009915
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020