DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ets98B and Spdef

DIOPT Version :9

Sequence 1:	NP_524535.2	Gene:	Ets98B / 43334	FlyBaseID:	FBgn0005659	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001103000.1	Gene:	Spdef / 689210	RGDID:	1594842	Length:	325	Species:	Rattus norvegicus

Alignment Length:	414	Identity:	132/414 - (31%)
Similarity:	168/414 - (40%)	Gaps:	139/414 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 PSPQSSPLQSEFAAYGLGRFGGSYDSLNSPSPSLEAVSIKQELHILPPSPPESNCETPSPRSSCG 171
            |||.::|.|      ||..|..||.::                     .|.:.:.....|.:|..
  Rat    45 PSPPATPEQ------GLSAFYLSYFNM---------------------YPEDGSWVAKVPEASAR 82

  Fly   172 ESIKAEPLDADIESLIDLNSLLQQQSLQSPQNLQDTKPDHQLLRECLEDTSFQKRHNLKPLALES 236
            |....||               :|..:...|...:|..:|.|
  Rat    83 EDHPEEP---------------EQCPVIDSQASGNTLDEHSL----------------------- 109

  Fly   237 FIGGLAEVRGDFEPVISLALEHAKREADAICAELQISQDPNGWSPAQVHAWLRSTLAQFRLPPV- 300
                        |.|.|:.:....::.:..|..|.|:.||..|||..|..||..|..|:||||.
  Rat   110 ------------EQVQSMVVGEVLKDIETACKLLNITADPGDWSPGNVQKWLLWTEHQYRLPPAG 162

  Fly   301 -ADLELHFCENGAALALLSEEEFVRRLPESGSTLHAQLEIWKMAYADQPAHQQHSQQSASTDHWP 364
             |..||    .|..|..:|||:|.:|.|..|..|||.|:|||.|                  .|.
  Rat   163 KAFQEL----GGKELCAMSEEQFRQRAPLGGDVLHAHLDIWKSA------------------AWM 205

  Fly   365 ASYAMP---HLDLDYNEDSEDDDDMEADAQVAPLNGSTTSPPATNASNGGTATVKRPNGGRTGGG 426
            .....|   |.....:|:...|.::::..                                   .
  Rat   206 KERTSPGALHYCASTSEEGWTDGEVDSSC-----------------------------------S 235

  Fly   427 GSHIHLWQFLKELLASPQVNGTAIRWIDRSKGIFKIEDSVRVAKLWGRRKNRPAMNYDKLSRSIR 491
            |..|||||||||||..|...|..|||:::.|||||||||.:||:|||.|||||||||||||||||
  Rat   236 GQPIHLWQFLKELLLKPHSYGRFIRWLNKEKGIFKIEDSAQVARLWGVRKNRPAMNYDKLSRSIR 300

  Fly   492 QYYKKGIMKKTERSQRLVYQFCHP 515
            |||||||::|.:.||||||||.||
  Rat   301 QYYKKGIIRKPDISQRLVYQFVHP 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ets98B	NP_524535.2	SAM_PNT-PDEF-like	264..345	CDD:188878	37/82 (45%)
Ets98B	NP_524535.2	ETS	429..517	CDD:197710	65/87 (75%)
Spdef	NP_001103000.1	SAM_PNT-PDEF-like	124..204	CDD:188878	37/101 (37%)
Spdef	NP_001103000.1	Ets	241..322	CDD:278602	60/80 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347742
Domainoid	1	1.000	133	1.000	Domainoid score	I4966
eggNOG	1	0.900	-	-		E1_KOG3805
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	183	1.000	Inparanoid score	I3872
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D388142at33208
OrthoFinder	1	1.000	-	-		FOG0006425
OrthoInspector	1	1.000	-	-		oto95967
orthoMCL	1	0.900	-	-		OOG6_108721
Panther	1	1.100	-	-	LDO	PTHR11849
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5385
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760