DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ets98B and SPIB

DIOPT Version :9

Sequence 1:	NP_524535.2	Gene:	Ets98B / 43334	FlyBaseID:	FBgn0005659	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_003112.2	Gene:	SPIB / 6689	HGNCID:	11242	Length:	262	Species:	Homo sapiens

Alignment Length:	269	Identity:	65/269 - (24%)
Similarity:	98/269 - (36%)	Gaps:	82/269 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 FEPVISLALEHAKREADAICAELQISQDPNGWSPAQVHAWLRSTLAQFRLPPVADLELHFCENGA 312
            |:|. :.|..|.  :|..:|.|      |..:|||          ....|.|..:..      |.
Human    61 FDPA-AAAFSHP--QAAQLCYE------PPTYSPA----------GNLELAPSLEAP------GP 100

  Fly   313 ALALLSEEEFVRRLPESGSTLHAQLEIWKMAYADQPAHQQHSQQSASTDHWPASYAMPHLDLDYN 377
            .|.....|.|            |...:...|||..|:.....::....|       .|.|::
Human   101 GLPAYPTENF------------ASQTLVPPAYAPYPSPVLSEEEDLPLD-------SPALEV--- 143

  Fly   378 EDSEDDDDMEADAQVAPLNGSTTSPPATNASNGGTATVKRPNG-GRTGGGGSHIHLWQFLKELLA 441
            .|||.|:                            |.|..|.| |...|....:.|:|||..||.
Human   144 SDSESDE----------------------------ALVAGPEGKGSEAGTRKKLRLYQFLLGLLT 180

  Fly   442 SPQVNGTAIRWIDRSKGIFKIEDSVR--VAKLWGRRK-NRPAMNYDKLSRSIRQYYKKGIMKKTE 503
            ...:. ..:.|::...|:|:.....:  :|:.||::| ||..|.|.||:|::|.|.|.|.::|.:
Human   181 RGDMR-ECVWWVEPGAGVFQFSSKHKELLARRWGQQKGNRKRMTYQKLARALRNYAKTGEIRKVK 244

  Fly   504 RSQRLVYQF 512
            |  :|.|||
Human   245 R--KLTYQF 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ets98B	NP_524535.2	SAM_PNT-PDEF-like	264..345	CDD:188878	14/80 (18%)
Ets98B	NP_524535.2	ETS	429..517	CDD:197710	30/87 (34%)
SPIB	NP_003112.2	TAD1 (Acidic)	1..31
		TAD2	41..61		65/269 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..163		10/53 (19%)
		ETS	168..256	CDD:197710	30/87 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3805
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11849
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910