Protein Alignment Ets98B and SPDEF

DIOPT Version :10

• Sequence 1: NP_524535.2
• Gene: Ets98B / 43334
• FlyBaseID: FBgn0005659
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: XP_005249045.2
• Gene: SPDEF / 25803
• HGNCID: 17257
• Length: 407
• Species: Homo sapiens
• Alignment Length: 484
• Identity: 150/484 - (30%)
• Similarity: 191/484 - (39%)
• Gaps: 167/484 - (34%)

  Fly    75 QPIQQQQQP--------TAPYTNPS--------------SHQLIPPPAYPHSAY----------- 106
            |..|:..:|        ||...|.|              ||.|:||.....:..
Human    47 QETQETSRPLSCGKLGDTAASPNSSGMGSASPGLSSVSPSHLLLPPDTVSRTGLEKAAAGAVGLE 111

  Fly   107 -----PSPQSSPLQSEFAAYGLGRFGGSYDSLNSPSPSLEAVSIKQELHILPPSPPESNCETPSP 166
                 |||.::|.|. .:|:.|..|...|...:|.:......|.::|    ||..|| .|..
Human   112 RRDWSPSPPATPEQG-LSAFYLSYFDMLYPEDSSWAAKAPGASSREE----PPEEPE-QCPV--- 167

  Fly   167 RSSCGESIKAEPLDADIESLIDLNSLLQQQSLQSPQNLQDTKPDHQLLRECLEDTSFQKRHNLKP 231
                            |:|             |:|....|..|
Human   168 ----------------IDS-------------QAPAGSLDLVP---------------------- 181

  Fly   232 LALESFIGGLAEVRGDFEPVISLALEHAKREADAICAELQISQDPNGWSPAQVHAWLRSTLAQFR 296
                   |||.......|.|.|:.:....::.:..|..|.|:.||..|||:.|..||..|..|:|
Human   182 -------GGLTLEEHSLEQVQSMVVGEVLKDIETACKLLNITADPMDWSPSNVQKWLLWTEHQYR 239

  Fly   297 LPPV--ADLELHFCENGAALALLSEEEFVRRLPESGSTLHAQLEIWKMAYADQPAHQQHSQQSAS 359
            |||:  |..||    .|..|..:|||:|.:|.|..|..|||.|:|||.|
Human   240 LPPMGKAFQEL----AGKELCAMSEEQFRQRSPLGGDVLHAHLDIWKSA---------------- 284

  Fly   360 TDHWPASYAMP---HLDLDYNEDSEDDDDMEADAQVAPLNGSTTSPPATNASNGGTATVKRPNGG 421
              .|......|   |.....:|:|..|.::::..
Human   285 --AWMKERTSPGAIHYCASTSEESWTDSEVDSSC------------------------------- 316

  Fly   422 RTGGGGSHIHLWQFLKELLASPQVNGTAIRWIDRSKGIFKIEDSVRVAKLWGRRKNRPAMNYDKL 486
                .|..|||||||||||..|...|..|||:::.|||||||||.:||:|||.||||||||||||
Human   317 ----SGQPIHLWQFLKELLLKPHSYGRFIRWLNKEKGIFKIEDSAQVARLWGIRKNRPAMNYDKL 377

  Fly   487 SRSIRQYYKKGIMKKTERSQRLVYQFCHP 515
            ||||||||||||::|.:.||||||||.||
Human   378 SRSIRQYYKKGIIRKPDISQRLVYQFVHP 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ets98B	NP_524535.2	SAM_PNT-PDEF-like	264..345	CDD:188878	37/82 (45%)
		ETS	429..517	CDD:197710	65/87 (75%)
SPDEF	XP_005249045.2	SAM_PNT-PDEF-like	206..286	CDD:188878	37/101 (37%)
		ETS	320..406	CDD:197710	63/85 (74%)