DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ets98B and ets-4

DIOPT Version :9

Sequence 1:	NP_524535.2	Gene:	Ets98B / 43334	FlyBaseID:	FBgn0005659	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001359862.1	Gene:	ets-4 / 180927	WormBaseID:	WBGene00017687	Length:	463	Species:	Caenorhabditis elegans

Alignment Length:	512	Identity:	146/512 - (28%)
Similarity:	214/512 - (41%)	Gaps:	129/512 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 TAPYTNPSSHQLIPPPAYPHSAYPSPQSSPLQSEFAAY-----GLGRFGGSYDSLNSPSPSLEAV 143
            ||.|.....|.|      ...|:|   .:.|:.::.:|     |.|..|..::|| ||.|.
Worm     2 TAAYCETQFHGL------NQFAFP---FNNLEYKYGSYSSSMNGTGSVGHRWNSL-SPEPH---- 52

  Fly   144 SIKQELHILPPSPPESNCETPSPRSSCGESIKAE-PLDADIESLIDLNSLLQQQSLQSPQNL--Q 205
                       |..||...||        .:|:| |.|.|:..:..:|: ::...:..|.||  |
Worm    53 -----------SGTESTASTP--------FVKSEFPFDDDLFGIDQVNN-VKPHPMDMPCNLPIQ 97

  Fly   206 DTKPDHQLLRECLEDTSFQKRH--------NLKPLALESFIGGLAEVRGDFEPVISLALEHAKRE 262
            ..:.:.:..::. :.::|.|..        |:.|...:.  .||...:.|.  ...|.|.|..::
Worm    98 PIEYNRRFSKDA-DHSTFVKNEIEENILNFNVNPEIAQD--NGLDTQQIDI--YRDLILRHLIQD 157

  Fly   263 ADAICAELQISQDPNGWSPAQVHAWLRSTLAQFRLPPVADLELHFCENGAALALLSEEEFVRRLP 327
            ....||:|.:..|...||......|:.....||.|.|..:..:    .|..|..:|:::|...||
Worm   158 ISTTCAKLGLPNDFYLWSSEHGARWINEMCMQFNLQPPRNCSI----TGIDLLGMSQKDFEMILP 218

  Fly   328 ESGSTLHAQLEIWKMAYAD--QPAHQQHSQQSA------STDHWPASY----------------- 367
            ..|.||||||::||.|:.:  .|...|.|..:|      |..:|.||.
Worm   219 AGGDTLHAQLQVWKTAFENYHPPVTVQSSGMTAAENNMQSKTNWLASTNNQTNNMAAAENPNHPF 283

  Fly   368 -----AMPHL------------------DLDYNEDSEDDDDMEADAQVAPLN----------GST 399
                 ..|::                  |...|..|:|.:|.:.|..:...|          |..
Worm   284 FNGNGGYPNMSMSSFFQQGTVLPSPSNSDTSSNGSSQDMNDDDIDLHMNNSNCGFSNFFHNQGYM 348

  Fly   400 TSP--PATNASNG--GTATVKRPNGGRTGGGGSHIHLWQFLKELLASPQVNGTAIRWIDRSKGIF 460
            .||  ...|.|.|  ......|..|        .:|||||::|||..|:.....:||:||.:|.|
Worm   349 NSPIDAMCNGSEGDDDERAYTRHQG--------TVHLWQFIRELLDQPKQYSACVRWVDRDEGTF 405

  Fly   461 KIEDSVRVAKLWGRRKNRPAMNYDKLSRSIRQYYKKGIMKKTERSQRLVYQFCHPYS 517
            |||.|:.:|:.||:||||..|||||||||:||||||||::|.|:.|||||:|..||:
Worm   406 KIESSLLLARYWGQRKNRSQMNYDKLSRSLRQYYKKGIIQKPEKKQRLVYKFLPPYN 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ets98B	NP_524535.2	SAM_PNT-PDEF-like	264..345	CDD:188878	27/80 (34%)
Ets98B	NP_524535.2	ETS	429..517	CDD:197710	52/87 (60%)
ets-4	NP_001359862.1	SAM_PNT-PDEF-like	158..236	CDD:188878	27/81 (33%)
ets-4	NP_001359862.1	ETS	374..462	CDD:197710	52/87 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163363
Domainoid	1	1.000	118	1.000	Domainoid score	I3676
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	179	1.000	Inparanoid score	I2677
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006425
OrthoInspector	1	1.000	-	-		oto20083
orthoMCL	1	0.900	-	-		OOG6_108721
Panther	1	1.100	-	-	LDO	PTHR11849
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5385
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.980