DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12877 and REX3

DIOPT Version :9

Sequence 1:	NP_001034073.1	Gene:	CG12877 / 43333	FlyBaseID:	FBgn0039544	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_013208.1	Gene:	REX3 / 850797	SGDID:	S000004097	Length:	404	Species:	Saccharomyces cerevisiae

Alignment Length:	323	Identity:	98/323 - (30%)
Similarity:	164/323 - (50%)	Gaps:	49/323 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   680 KGKLSSLGNGEPF----DALDAEKAYKMVFDLRLTEEQLVENGYPRPGDKRGSAVIRACR-PNRR 739
            |..|||:||....    .|::|.||  ::.|.::.|    :|||          :::..: ....
Yeast    98 KPHLSSIGNANSITTKSKAMEALKA--LILDSKVLE----KNGY----------IVKEMQNKTND 146

  Fly   740 PNQKERY--CSRCGKVF-SLDIYEHQSFDMCNYHPKSTGYRRGFTDHQHRCCQQPAGTP-----G 796
            .|..:.|  |.||...| ..||.|.   .:|.|||....|.|...:||:.||.:...:.     |
Yeast   147 DNSTQLYAPCLRCSSNFKKTDIMEK---TLCRYHPLKRIYNRDTKNHQYPCCGETTDSVSFLRLG 208

  Fly   797 CTYANYHV--SDYYDPE-KLTCFVKTIERGEEFVPTKKDIYALDCEMCYTTHGIELTRVTVVD-I 857
            |....:||  .:.||.. |::.|..|     :.:...:::.:|||||.:|:.|.|:.|:|:|| .
Yeast   209 CKTFFHHVFRGESYDELCKISKFSST-----DDIDGVENVLSLDCEMAFTSLGYEMIRLTIVDFF 268

  Fly   858 NGRSVYDALVKPDNQIVDYNTTYSGITEAMLSNETRTIRDVQAVLMS--MFHAKTVLVGHSLESD 920
            .|::::|.:::|...|||.|:.:||:.|...:| ..|.::...|.:|  :.:..::|:||.||:|
Yeast   269 TGKTLFDHVIQPIGDIVDLNSDFSGVHEIDRTN-CPTYKEALDVFLSENLINKNSILIGHGLEND 332

  Fly   921 LKALKLIHDVVVDTSVLFPHKMGPPKKRALKTLCIENLKRIIQESEAGHDSAEDAEVCIQLIK 983
            |..::|.|:.|:||::|:..   ...|.:||.|..|.|.|.||..|  |||::||...:.::|
Yeast   333 LNVMRLFHNKVIDTAILYSR---TKFKVSLKNLAFEVLSRKIQNGE--HDSSQDAIATMDVVK 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12877	NP_001034073.1	CDC45	129..>199	CDD:280821
		EloA-BP1	572..736	CDD:292495	15/60 (25%)
		REX1_like	834..983	CDD:99848	54/151 (36%)
		DnaQ	847..>991	CDD:223916	48/140 (34%)
REX3	NP_013208.1	REX1_like	244..390	CDD:99848	54/151 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346334
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103246
Panther	1	1.100	-	-	O	PTHR12801
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2254
SonicParanoid	1	1.000	-	-		X1541
TreeFam	0	0.000	Not matched by this tool.
	8	7.770