Protein Alignment CG12877 and REXO1

DIOPT Version :10

• Sequence 1: NP_001034073.1
• Gene: CG12877 / 43333
• FlyBaseID: FBgn0039544
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: XP_011526446.1
• Gene: REXO1 / 57455
• HGNCID: 24616
• Length: 1382
• Species: Homo sapiens
• Alignment Length: 1269
• Identity: 330/1269 - (26%)
• Similarity: 484/1269 - (38%)
• Gaps: 372/1269 - (29%)

  Fly     1 MLPSTGLFKGFLCPYFDGQDAASCKRPFCHFKH-------ARKDELEAAP----------PAEPS 48
            ||.|||.|:...|||:.|.....|:||:|||:|       |..|..||.|          |..|.
Human     1 MLRSTGFFRAIDCPYWSGAPGGPCRRPYCHFRHRGARGSGAPGDGGEAPPAAGLGYDPYNPELPK 65

  Fly    49 PVPK---------YKPAPKLLSLPLPQITLCAPRKKSNLE------------------------- 79
            |..:         .:|.|.:|.|.|....:.|.|.:..||
Human    66 PPAQRENGTLGLGEEPRPDVLELELVNQAIEAVRSEVELEQRRYRELLETTREHRSAEAPALAPR 130

  Fly    80 ----------------------------------YHPEKPALDASPAKKKQEASVD--------- 101
                                              |.|...|..|.|..|...||:|
Human   131 GPNASPTVGPDEDAFPLAFDYSPGSHGLLSPDAGYQPTPLAAPAEPGSKYSLASLDRGQGRGGGG 195

  Fly   102 -SAPKYVP---GQP-----SVTNGE------------EYDDWQAVLEKEI------DEQMQVEIE 139
             .|.:|||   .||     .|.:|:            |||.......:.:      ||:......
Human   196 GGALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPR 260

  Fly   140 E---------------------QVQNNDEEQKIDTVAENEEDQENTQLTDARDSHEKDRKPSKER 183
            .                     ..:.:|.|.:..||..||....:|....|....:...:|..:.
Human   261 GSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKE 325

  Fly   184 ERDIEKKKIRELKREKIK-------------------DRDRD----------------------R 207
            ..:.|...:||.|...::                   ...:|                      :
Human   326 GLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCK 390

  Fly   208 DRDREKDKEKSKERDREKEKNDRDKRKSSHSDKERSKERNTSSSSSSKHKSSSSSSSSKKSSSSD 272
            |..:.|||.|.|.|.|..||...||:....|...|..||    ...:|.|.||::    ..::|.
Human   391 DGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAER----PEGTKKKPSSAT----PVATSG 447

  Fly   273 KHRDDK--------SSSSR--------------HKSSSSSSSSKSHHHKSSS-----SSSRSKTK 310
            |.|.|:        |..||              .:.|:.:.|.|....|:.|     |....|.|
Human   448 KGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLK 512

  Fly   311 RSSSSSKSAGTSKSEPEA--------------------DKDTEAAVLTP----------AEPMD- 344
            :.:.|.......:||.||                    |.|:::::..|          |.|..
Human   513 KRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPS 577

  Fly   345 ------------------DLD----DMDFDFEADTSEGEIVRQCEMIFDEMEKKFAQMHKDEGGN 387
                              |:|    :.:.||::|..|     :|..||:|.    ..:..::.|.
Human   578 PAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDPME-----ECLRIFNES----TSVKTEDRGR 633

  Fly   388 ANPESSRKRKAPSPDIDTFTEAATAALQKRRVAH---ENADKITPHLAPSAAMRKPNHVRNAMQA 449
            ...:..::.|:....:...|.....  ||||::|   :..:...|...|:....:|   ..|.:.
Human   634 LARQPPKEEKSEEKGLSGLTTLFPG--QKRRISHLSKQGQEVEPPRRGPAVPPARP---PTAQEV 693

  Fly   450 IFNRRAELRRQEKLQAEASAEQVRQAQERVRQAQEELRQAKVNSNLTPLISRSALTPPVRSARSI 514
            .:     ||.|:..:|.||   :.||..|:.:.             :|.:..||  |..:  |.|
Human   694 CY-----LRAQQAQRASAS---LLQAPARLAEK-------------SPSVHISA--PGEK--RRI 733

  Fly   515 APVAN---IVAIARAKKKIEELQAEKKPAFTP------AQSFKGAG----------RVAHKPTAA 560
            |.:.|   ..|...||:.:....::......|      .::..|..          |:||.|:
Human   734 AHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMASKTTTTIIPKRIAHSPS-- 796

  Fly   561 LDKAAPVSNAEKPTVLDPSSSKISYNVRIQYYEMMVRHCTVIYPQLADAWERAQVEELTVFKKCN 625
                  :.:.:||.:......|:...:|.:|..:.:..|........:|.|:|..||...:.:..
Human   797 ------LQSLKKPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKVAYDRSP 855

  Fly   626 TPAIYKNSCMLAINKLRKEALEA--GNKPSVACKTVSHEMMLGGKRALTTSWSVEKKGKLSSLGN 688
            :..||.|..:..:.|||..|..|  |...:...:.||||::|||:.|..||:|:.:.       :
Human   856 SKNIYLNVAVNTLKKLRGLAPSAVPGLSKTSGRRVVSHEVVLGGRLAAKTSFSLSRP-------S 913

  Fly   689 GEPFDALDAEKAYKMVFDLRLTEEQLVENGYPRPGDKRGSAVIRACRPNRRPNQKE--------- 744
            ....:.|.....|..:.:..||::||.|||||.|..:|....|......:||...|
Human   914 SPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAIIFTAEEKRPKDCESLACDGLAS 978

  Fly   745 -RYCSRCGKVFSLD-----IYEHQSFDMCNYHPKSTGYRR--GFTDHQHRCCQQPAGTPGCTYAN 801
             |.|.|||..:.:.     |.:.:    |.||.......|  |..:.|:.||...||:.||..|.
Human   979 CRTCCRCGTEYLVSSSGRCIRDEE----CYYHWGRLRRNRVAGGWETQYMCCSAAAGSVGCQVAK 1039

  Fly   802 YHVSDYYDPEKLTCFVKTIERGEEFVPTKKDIYALDCEMCYTTHGIELTRVTVVDINGRSVYDAL 866
            .||.| ...|:|..||||.|: |....|...||||||||.|||:|:|||||||||.:...|||..
Human  1040 QHVQD-GRKERLEGFVKTFEK-ELSGDTHPGIYALDCEMSYTTYGLELTRVTVVDTDVHVVYDTF 1102

  Fly   867 VKPDNQIVDYNTTYSGITEAMLSNETRTIRDVQAVLMSMFHAKTVLVGHSLESDLKALKLIHDVV 931
            |||||:||||||.:||:|||.|::.:.|:|||||||:|||.|.|:|:||||||||.|||:||..|
Human  1103 VKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILIGHSLESDLLALKVIHSTV 1167

  Fly   932 VDTSVLFPHKMGPPKKRALKTLCIENLKRIIQES 965
            |||||||||::|.|.||:|:.|..:.|::|||::
Human  1168 VDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDN 1201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12877	NP_001034073.1	PTZ00121	<128..490	CDD:173412	92/512 (18%)
		PRK05035	<458..>583	CDD:481472	27/143 (19%)
		EloA-BP1	572..734	CDD:464914	45/163 (28%)
		REX1_like	834..983	CDD:99848	87/132 (66%)
REXO1	XP_011526446.1	PHA03247	<115..481	CDD:223021	63/373 (17%)
		PTZ00449	<400..688	CDD:185628	62/309 (20%)
		EloA-BP1	802..960	CDD:464914	45/164 (27%)
		REX1_like	1070..1203	CDD:99848	87/132 (66%)
		PHA03247	<1207..1367	CDD:223021