DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12877 and REXO1

DIOPT Version :9

Sequence 1:NP_001034073.1 Gene:CG12877 / 43333 FlyBaseID:FBgn0039544 Length:991 Species:Drosophila melanogaster
Sequence 2:XP_011526446.1 Gene:REXO1 / 57455 HGNCID:24616 Length:1382 Species:Homo sapiens


Alignment Length:1269 Identity:330/1269 - (26%)
Similarity:484/1269 - (38%) Gaps:372/1269 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLPSTGLFKGFLCPYFDGQDAASCKRPFCHFKH-------ARKDELEAAP----------PAEPS 48
            ||.|||.|:...|||:.|.....|:||:|||:|       |..|..||.|          |..|.
Human     1 MLRSTGFFRAIDCPYWSGAPGGPCRRPYCHFRHRGARGSGAPGDGGEAPPAAGLGYDPYNPELPK 65

  Fly    49 PVPK---------YKPAPKLLSLPLPQITLCAPRKKSNLE------------------------- 79
            |..:         .:|.|.:|.|.|....:.|.|.:..||                         
Human    66 PPAQRENGTLGLGEEPRPDVLELELVNQAIEAVRSEVELEQRRYRELLETTREHRSAEAPALAPR 130

  Fly    80 ----------------------------------YHPEKPALDASPAKKKQEASVD--------- 101
                                              |.|...|..|.|..|...||:|         
Human   131 GPNASPTVGPDEDAFPLAFDYSPGSHGLLSPDAGYQPTPLAAPAEPGSKYSLASLDRGQGRGGGG 195

  Fly   102 -SAPKYVP---GQP-----SVTNGE------------EYDDWQAVLEKEI------DEQMQVEIE 139
             .|.:|||   .||     .|.:|:            |||.......:.:      ||:......
Human   196 GGALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPR 260

  Fly   140 E---------------------QVQNNDEEQKIDTVAENEEDQENTQLTDARDSHEKDRKPSKER 183
            .                     ..:.:|.|.:..||..||....:|....|....:...:|..:.
Human   261 GSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKE 325

  Fly   184 ERDIEKKKIRELKREKIK-------------------DRDRD----------------------R 207
            ..:.|...:||.|...::                   ...:|                      :
Human   326 GLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCK 390

  Fly   208 DRDREKDKEKSKERDREKEKNDRDKRKSSHSDKERSKERNTSSSSSSKHKSSSSSSSSKKSSSSD 272
            |..:.|||.|.|.|.|..||...||:....|...|..||    ...:|.|.||::    ..::|.
Human   391 DGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAER----PEGTKKKPSSAT----PVATSG 447

  Fly   273 KHRDDK--------SSSSR--------------HKSSSSSSSSKSHHHKSSS-----SSSRSKTK 310
            |.|.|:        |..||              .:.|:.:.|.|....|:.|     |....|.|
Human   448 KGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLK 512

  Fly   311 RSSSSSKSAGTSKSEPEA--------------------DKDTEAAVLTP----------AEPMD- 344
            :.:.|.......:||.||                    |.|:::::..|          |.|.. 
Human   513 KRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPS 577

  Fly   345 ------------------DLD----DMDFDFEADTSEGEIVRQCEMIFDEMEKKFAQMHKDEGGN 387
                              |:|    :.:.||::|..|     :|..||:|.    ..:..::.|.
Human   578 PAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDPME-----ECLRIFNES----TSVKTEDRGR 633

  Fly   388 ANPESSRKRKAPSPDIDTFTEAATAALQKRRVAH---ENADKITPHLAPSAAMRKPNHVRNAMQA 449
            ...:..::.|:....:...|.....  ||||::|   :..:...|...|:....:|   ..|.:.
Human   634 LARQPPKEEKSEEKGLSGLTTLFPG--QKRRISHLSKQGQEVEPPRRGPAVPPARP---PTAQEV 693

  Fly   450 IFNRRAELRRQEKLQAEASAEQVRQAQERVRQAQEELRQAKVNSNLTPLISRSALTPPVRSARSI 514
            .:     ||.|:..:|.||   :.||..|:.:.             :|.:..||  |..:  |.|
Human   694 CY-----LRAQQAQRASAS---LLQAPARLAEK-------------SPSVHISA--PGEK--RRI 733

  Fly   515 APVAN---IVAIARAKKKIEELQAEKKPAFTP------AQSFKGAG----------RVAHKPTAA 560
            |.:.|   ..|...||:.:....::......|      .::..|..          |:||.|:  
Human   734 AHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMASKTTTTIIPKRIAHSPS-- 796

  Fly   561 LDKAAPVSNAEKPTVLDPSSSKISYNVRIQYYEMMVRHCTVIYPQLADAWERAQVEELTVFKKCN 625
                  :.:.:||.:......|:...:|.:|..:.:..|........:|.|:|..||...:.:..
Human   797 ------LQSLKKPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKVAYDRSP 855

  Fly   626 TPAIYKNSCMLAINKLRKEALEA--GNKPSVACKTVSHEMMLGGKRALTTSWSVEKKGKLSSLGN 688
            :..||.|..:..:.|||..|..|  |...:...:.||||::|||:.|..||:|:.:.       :
Human   856 SKNIYLNVAVNTLKKLRGLAPSAVPGLSKTSGRRVVSHEVVLGGRLAAKTSFSLSRP-------S 913

  Fly   689 GEPFDALDAEKAYKMVFDLRLTEEQLVENGYPRPGDKRGSAVIRACRPNRRPNQKE--------- 744
            ....:.|.....|..:.:..||::||.|||||.|..:|....|......:||...|         
Human   914 SPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAIIFTAEEKRPKDCESLACDGLAS 978

  Fly   745 -RYCSRCGKVFSLD-----IYEHQSFDMCNYHPKSTGYRR--GFTDHQHRCCQQPAGTPGCTYAN 801
             |.|.|||..:.:.     |.:.:    |.||.......|  |..:.|:.||...||:.||..|.
Human   979 CRTCCRCGTEYLVSSSGRCIRDEE----CYYHWGRLRRNRVAGGWETQYMCCSAAAGSVGCQVAK 1039

  Fly   802 YHVSDYYDPEKLTCFVKTIERGEEFVPTKKDIYALDCEMCYTTHGIELTRVTVVDINGRSVYDAL 866
            .||.| ...|:|..||||.|: |....|...||||||||.|||:|:|||||||||.:...|||..
Human  1040 QHVQD-GRKERLEGFVKTFEK-ELSGDTHPGIYALDCEMSYTTYGLELTRVTVVDTDVHVVYDTF 1102

  Fly   867 VKPDNQIVDYNTTYSGITEAMLSNETRTIRDVQAVLMSMFHAKTVLVGHSLESDLKALKLIHDVV 931
            |||||:||||||.:||:|||.|::.:.|:|||||||:|||.|.|:|:||||||||.|||:||..|
Human  1103 VKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILIGHSLESDLLALKVIHSTV 1167

  Fly   932 VDTSVLFPHKMGPPKKRALKTLCIENLKRIIQES 965
            |||||||||::|.|.||:|:.|..:.|::|||::
Human  1168 VDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDN 1201

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12877NP_001034073.1 CDC45 129..>199 CDD:280821 15/96 (16%)
EloA-BP1 572..736 CDD:292495 45/165 (27%)
REX1_like 834..983 CDD:99848 87/132 (66%)
DnaQ 847..>991 CDD:223916 76/119 (64%)
REXO1XP_011526446.1 EloA-BP1 802..962 CDD:292495 45/166 (27%)
REX1_like 1070..1203 CDD:99848 87/132 (66%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 231 1.000 Domainoid score I2441
eggNOG 1 0.900 - - E1_COG0847
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 359 1.000 Inparanoid score I2224
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002085
OrthoInspector 1 1.000 - - otm40737
orthoMCL 1 0.900 - - OOG6_103246
Panther 1 1.100 - - LDO PTHR12801
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2254
SonicParanoid 1 1.000 - - X1541
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.850

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