Protein Alignment CG12877 and PAN2

DIOPT Version :10

• Sequence 1: NP_001034073.1
• Gene: CG12877 / 43333
• FlyBaseID: FBgn0039544
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_610427.2
• Gene: PAN2 / 35893
• FlyBaseID: FBgn0033352
• Length: 1241
• Species: Drosophila melanogaster
• Alignment Length: 839
• Identity: 160/839 - (19%)
• Similarity: 259/839 - (30%)
• Gaps: 318/839 - (37%)

  Fly   285 KSSSSSSSSKSHHHKS------SSSSSRSKTKRSSS------------------------SSKSA 319
            ||::||....|:..:|      :|:.....|.|||:                        |||:|
  Fly   557 KSTASSPCQASNFLRSFRTVPEASALGLILTDRSSNVNLISLIQNWNRFILHQMHYEIFDSSKNA 621

  Fly   320 GTSKSEPEADKDTEAAVLTPAEPMDDLDDMDFDFEADTSEGEIVRQCEMIFDEMEKKFAQMHKDE 384
            .|.....:...:.|.|..:......||.|                   .|.||..|
  Fly   622 STYSGSVQTSTNAENAGSSETSGSSDLYD-------------------SISDENSK--------- 658

  Fly   385 GGNANPESSRKRKAPSPDIDTFTEAATAALQKRRVAHENADKITPHLAPSAAMRKPNHVRNAMQA 449
                  |..|:|...:.:.|......|..:...|......:||...:..:..:..|||::::.|
  Fly   659 ------EDDRERSKINAETDISKIFGTKQICINRCIKCQEEKIKESILLACNLSYPNHIKDSDQ- 716

  Fly   450 IFNRRAELRRQEKLQAEASAEQVRQAQERVRQAQEELRQAKVNSNLTPLISRSALTPPVRSARSI 514
            .||....|:|  .|.:|.|   ::...||.::.....:..||.|           .|.:.|...
  Fly   717 YFNFGTILKR--SLSSEKS---IQAFCERCKKFSPTNQSVKVTS-----------LPQILSINC- 764

  Fly   515 APVANIVAIARAKKKIEELQAEKKPAFTPAQSFKGAGRVAHKPTAALDKAAPVSNAEKPTVLDPS 579
                             .|..||...|...|    ..|.:.|.|  :|.||.:|.: ||.....:
  Fly   765 -----------------GLNNEKDITFLKRQ----LNRCSEKTT--VDAAASLSTS-KPCRYGAN 805

  Fly   580 SSKISYNVRIQYYEMMVRHCTVIYPQLADAWERAQVEELTVFKKCNTPAIYKNSCMLAINKLRKE 644
            .|:              ..|..::|........:|..                    |:|
  Fly   806 CSR--------------SDCHFMHPDRKSPSHTSQPN--------------------AVN----- 831

  Fly   645 ALEAGNKPSVACKTVSHEMMLGGKRA---LTTSWSVEKKGKL-------SSLGNGE--------P 691
                 |.|:            |.:::   ||.:..:..:|::       :|.|..|        |
  Fly   832 -----NSPN------------GRQKSWFPLTFTMGINDQGEVQVQTQSDASSGKSEQEEETEKPP 879

  Fly   692 FDALDAEKAYKM------VFDLRLTEEQLVENGYPRPGDKRGSAVIRACRPNRRPNQKERYCSRC 750
            ...||..:.|.:      |.|  .|::.||             ::|...||.......|
  Fly   880 TKGLDNNRMYALHAVVCQVDD--GTQKNLV-------------SLINVQRPYHTMKLAE------ 923

  Fly   751 GKVFSLD-----IYEHQSFDMCNYHPKSTGYRRGFT-DHQHRCCQQPAGTPGCTYANYHVSDYYD 809
                |.|     .|....|.:....|:.:.:   || |.:         .| |.....||.|  |
  Fly   924 ----SADDPQSQWYIFNDFSISPVSPQESVW---FTLDWK---------VP-CILFYRHVED--D 969

  Fly   810 PEKLTCFVKTIERGEEFVPTKK------------------------------------------D 832
            .|..:....|:...||.:|::.                                          |
  Fly   970 SESASTTSSTVTESEETIPSESSSGSPTNLSNPFLEEIVSPMLGNLSADATLQPLQSDEMPQSGD 1034

  Fly   833 IYALDCEM---------------------CYTTHGIELTRVTVV----DINGRSVYDALVKPDNQ 872
            :.|:|.|.                     |:    :.:.|::.:    ...|....|..:....:
  Fly  1035 LVAMDAEFVTLNPEENEIRPDGKTATIKPCH----MSVARISCIRGQGPAEGVPFMDDYISTQEK 1095

  Fly   873 IVDYNTTYSGI----TEAMLSNETRT-IRDVQAVLMSMFHAKTVLVGHSLESDLKALKLI--HDV 930
            :|||.|.:|||    .:|..|.:..| ::.....|..:.....:.|||.|::|.:.:.:.  .:.
  Fly  1096 VVDYLTQFSGIKPGDLDANFSKKRLTALKYSYQKLKYLVDVGVIFVGHGLKNDFRVINIYVPSEQ 1160

  Fly   931 VVDTSVLF--PHKMGPPKKRALKTLCIENLKRIIQESEAGHDSAEDAEVCIQLIKYYLR 987
            ::||..||  ||.    :..:|:.|....|...|| ||. |||.|||...:||.|:||:
  Fly  1161 IIDTVHLFHMPHH----RMVSLRFLAWHFLGTKIQ-SET-HDSIEDARTTLQLYKHYLK 1213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12877	NP_001034073.1	PTZ00121	<128..490	CDD:173412	46/234 (20%)
		PRK05035	<458..>583	CDD:481472	26/124 (21%)
		EloA-BP1	572..734	CDD:464914	27/185 (15%)
		REX1_like	834..983	CDD:99848	44/182 (24%)
PAN2	NP_610427.2	WD40	63..>270	CDD:475233
		WD40 repeat	148..183	CDD:293791
		WD40 repeat	187..221	CDD:293791
		WD40 repeat	227..273	CDD:293791
		WD40 repeat	278..314	CDD:293791
		UCH_1	505..940	CDD:463872	97/539 (18%)
		zf-CCCH_2	799..816	CDD:464217	3/30 (10%)
		PAN2_exo	1036..1209	CDD:99846	44/182 (24%)