Protein Alignment CG12877 and Rexo1

DIOPT Version :10

• Sequence 1: NP_001034073.1
• Gene: CG12877 / 43333
• FlyBaseID: FBgn0039544
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_001012114.2
• Gene: Rexo1 / 314630
• RGDID: 1309872
• Length: 1197
• Species: Rattus norvegicus
• Alignment Length: 1293
• Identity: 339/1293 - (26%)
• Similarity: 505/1293 - (39%)
• Gaps: 409/1293 - (31%)

  Fly     1 MLPSTGLFKGFLCPYFDGQDAASCKRPFCHFKH-------------------------------- 33
            ||.|||.|:...|||:.|.....|:||:|||:|
  Rat     1 MLRSTGFFRSIDCPYWAGAPGGPCRRPYCHFRHRGARGPGAPGSGGVTSPAAGLGYDPYNPELPQ 65

  Fly    34 ---------------------------ARKDELE---------------------AAPPAEP--- 47
                                       |.:.|:|                     |..|..|
  Rat    66 PPVQRENGALGQGDGMLELELVNQAIEAVRGEVELEQRRYQELLETARGHGAGASALAPCSPATS 130

  Fly    48 -------------------SPVPKYKPAPKLLSLPLP---QITLCAPRKKSN---------LEYH 81
                               ||...|:|.|  |::|..   :.:| ||..:..         |||.
  Rat   131 MDDDDTFSLALTYTPGGLLSPDAAYQPTP--LAVPAEPGHKYSL-APSDRGQSRAAGGAGALEYV 192

  Fly    82 PE----------------KPALDA------------------------------------SPAKK 94
            |:                ||:.|.                                    :||.|
  Rat   193 PKAVGQPRRGGKYVVDSSKPSTDLEYDPLSNYSARHLGRTSTRDERATKRPRGSRGTEPYTPALK 257

  Fly    95 K--------------QEASVDSAPK------YVPGQPSVTNGEEYDDWQAVLEKEIDEQMQVEIE 139
            |              .|..|.|.||      ..||:|....|.|.::....:.||:  .:|.::|
  Rat   258 KPCDPSGGCEARFSDSEDDVSSPPKADDPESKAPGKPVSKEGIEPEEGSLRVTKEM--AVQYDVE 320

  Fly   140 EQVQNNDEEQKIDTVAENEEDQENTQLTDARDSHEKDRKPSK--ERERDIEKKKIRELKREK--- 199
            :..|.......:..|                       |||.  ...:|....|..:.|::|
  Rat   321 DLGQPPKAPDTVSVV-----------------------KPSSPARASQDAGVPKEGKAKKKKSGT 362

  Fly   200 ---IKDRDRDRDRDREKDKEKSKERDREKEKNDRDKRKSSHSDK------ERSKERNTSS---SS 252
               :..:|:.|.:|::|:|:.::.|.:||...|| |:.||.|.:      |.:|::.:|:   :|
  Rat   363 PASLSHKDKVRKKDKKKEKDPARPRGKEKVCADR-KKLSSSSPRGKAQGLEGTKKKPSSATTVAS 426

  Fly   253 SSK----HKSS-------------------------SSSSSSKKSSSSDK--HRDDKSSSSRHKS 286
            |.|    |.||                         |...:.:|:.|.|:  .:|......|..|
  Rat   427 SGKGGTGHPSSTGPQDRGPNSRAPLAWKGGCAKKMPSVKLAERKTRSLDEGAPQDTPKLKKRALS 491

  Fly   287 SSSSSSSKSHHHKS-----------SSSSSRSKTKRSSSSSKSAGTSKSEPEADKDTEAAVLTPA 340
            .:.....:|....|           :..|..|.::..|.||...|.:| .|:..|....|...|.
  Rat   492 HAELFGDESEEEDSGLGTAPRVWPPTLPSLSSDSESDSDSSLGLGETK-VPKRLKAAPPASPAPP 555

  Fly   341 EPMDDLD-----------------DMDFDFEADTSEGEIVRQCEMIFDEMEKKFAQMHKDEGGNA 388
            .|:....                 :.:.|.:.|..|     :|..||:|   ..:...:|:|..|
  Rat   556 SPLSSSSSSGASQCAEEGVGYSALEKELDLDVDPME-----ECLRIFNE---STSVKTEDKGRLA 612

  Fly   389 NPESSRKRKAPSPDIDTFTEAATAAL---QKRRVAH-------ENADKITPHLAPSAAMRKPNHV 443
                   |:.|....:..|.|....|   |||||:|       ..|.|.|| :||.|  |.|
  Rat   613 -------RQPPKEKAEEETHAGLTTLFPGQKRRVSHLSKPGKEAEAPKRTP-VAPPA--RPP--- 664

  Fly   444 RNAMQAIFNRRAELRRQEK---LQAEASAEQVRQAQERVRQAQ-----EELRQAKV-NSNLTPLI 499
              ..|.:..|||:..:::.   |||      |.:..||:....     |:.|.|.| |..|.
  Rat   665 --TAQEVCYRRAQQAQRDSASWLQA------VPRPTERLSSVHISAPGEKRRIAHVPNPRLA--- 718

  Fly   500 SRSALTPPVRSARSIAPVANIVAIARAKKKIEELQAEKKPAFTPAQSFKGAG------------R 552
                 .||..:.|:: |.:.           .::....:|...|.::...:|            |
  Rat   719 -----APPTGAKRAL-PASG-----------SQVSHGPEPGSQPLKTRTLSGMASKTTTTVTPKR 766

  Fly   553 VAHKPTAALDKAAPVSNAEKPTVLDPSSSKISYNVRIQYYEMMVRHCTVIYPQLADAWERAQVEE 617
            :||.|:        :.:.:||.:......|:...||.:|..:.:..|........:|.|:|..||
  Rat   767 MAHSPS--------LQSLKKPVIPKEFGGKVPTVVRQRYLNLFIEECLKFCSSNQEAIEKALNEE 823

  Fly   618 LTVFKKCNTPAIYKNSCMLAINKLRK-EALEAGNKPSV----ACKTVSHEMMLGGKRALTTSWSV 677
            ...:.:..:..||.|   :|:|.|:| ..|.....|::    :.:.||||::||||.|..||:|:
  Rat   824 KVAYDRSPSKNIYLN---VAVNTLKKLRGLVPNAVPNLSKASSRRVVSHEVVLGGKLAAKTSFSL 885

  Fly   678 EKKGKLSSLGNGEPFDALDAEKAYKMVFDLRLTEEQLVENGYPRPGDKR-GSAVIRACRPNRRPN 741
            .:.       :....:.|.....|..:.:..||.|||.|||||.|..:| |.|||......:..:
  Rat   886 SRP-------SSPRVEELKGTALYSRLREYLLTPEQLKENGYPFPHPERPGGAVIFTAEEKKPKD 943

  Fly   742 QKERYCSRCGKVFSLD-----IYEHQSFDMCNYHPKSTGYRR--GFTDHQHRCCQQPAGTPGCTY 799
            ...|.|.|||..:.:.     :...:    |.||.......|  |..:.|:.||....|:.||..
  Rat   944 PSCRICCRCGTEYLVSSSGRCVRNEE----CYYHWGRLRRNRVAGGWETQYMCCSAAVGSVGCQV 1004

  Fly   800 ANYHVSDYYDPEKLTCFVKTIERGEEFVPTKKDIYALDCEMCYTTHGIELTRVTVVDINGRSVYD 864
            |..||.| ...|.|..||:|.:: |........::||||||.|||:|:|||||||||.:.:.|||
  Rat  1005 AKQHVQD-GRKENLEGFVRTFQK-ELPEDAHAGVFALDCEMSYTTYGLELTRVTVVDTDMQVVYD 1067

  Fly   865 ALVKPDNQIVDYNTTYSGITEAMLSNETRTIRDVQAVLMSMFHAKTVLVGHSLESDLKALKLIHD 929
            ..|||||.:|||||.:||:|||.|.:.:.|:|||||||:|||.|.|:|:||||||||.|||:||.
  Rat  1068 TFVKPDNAVVDYNTRFSGVTEADLVDTSITLRDVQAVLLSMFSADTILIGHSLESDLLALKVIHG 1132

  Fly   930 VVVDTSVLFPHKMGPPKKRALKTLCIENLKRIIQESEAGHDSAEDAEVCIQLIKYYLR 987
            .||||||||||::|.|.||:|:.|..:.|::|||::..||.|:|||..|:.|:.:.:|
  Rat  1133 TVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNVDGHSSSEDASACMHLVIWKIR 1190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12877	NP_001034073.1	PTZ00121	<128..490	CDD:173412	99/455 (22%)
		PRK05035	<458..>583	CDD:481472	25/145 (17%)
		EloA-BP1	572..734	CDD:464914	51/167 (31%)
		REX1_like	834..983	CDD:99848	93/148 (63%)
Rexo1	NP_001012114.2	PHA03247	<9..404	CDD:223021	74/423 (17%)
		PRK12323	<644..795	CDD:481241	40/192 (21%)
		EloA-BP1	778..936	CDD:464914	51/167 (31%)
		REX1_like	1037..1185	CDD:99848	92/147 (63%)