DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12877 and rex3

DIOPT Version :9

Sequence 1:	NP_001034073.1	Gene:	CG12877 / 43333	FlyBaseID:	FBgn0039544	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_594715.1	Gene:	rex3 / 2542165	PomBaseID:	SPAC1782.08c	Length:	540	Species:	Schizosaccharomyces pombe

Alignment Length:	630	Identity:	148/630 - (23%)
Similarity:	237/630 - (37%)	Gaps:	185/630 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   422 ENADKITPHLA------PSAAMRK--PNHVRNAMQAI------------------FNRRAELRRQ 460
            :|:.||:|..:      |...:.|  |....|...:|                  ||.|..:  .
pombe    34 QNSTKISPPYSENVEGYPKVKIEKSLPYKYDNCKLSICVPIVTTCIPYHSVENLNFNIRQNI--S 96

  Fly   461 EKLQAEASAEQVRQAQ-ERVRQAQEELRQAK-VNSNLTPLISRSALTPPVRSARSIAPVANIVAI 523
            ..|..|.:.:.:::.: |..|....|..:.| :|...|.|.:.:.|     ..||:  ..:.::|
pombe    97 TTLNLEKTNDSIKETKNENFRMDVLETYKCKQLNHQTTHLPTNTVL-----KKRSL--FNDAISI 154

  Fly   524 ARAKKKIEELQAEKKPAFTPAQSFKGAGRVAHKPTAALDKAAPVSNAEKPTVLDPSSSKISYNVR 588
            ...|||      :...|.:.....:||.... .||...|..:|..
pombe   155 VPNKKK------QLVSAISTNSDSQGASSNI-IPTPKYDSNSPAG-------------------- 192

  Fly   589 IQYYEMMVRHCTVIYPQLAD-AWERAQ------VEELTVFKKCNTPAIYKNSC---MLAINKLRK 643
               :|:..|...::|....| .:..|:      ::|..:.:..|:..||.:||   :|::.|..|
pombe   193 ---HELRKRMTHLLYESYKDLGYSNAESSMLALLDEKNICETANSKMIYSSSCKSKILSLKKAPK 254

  Fly   644 EALEAGNKPSVACKTVSHEMMLGGKRALTTSWSVEKKGKLSSLGNGEPFDALDAEKAYKMVFDLR 708
            :....|:.|....:::.|
pombe   255 KNEIQGSTPDEKLESLVH----------------------------------------------- 272

  Fly   709 LTEEQLVENGYPRPGDKRGSAVIRACRPNRRPNQKERYCSRCGKVFSLDIYEHQSFDMCNYHPKS 773
             :||:|:..|| ..||         ..|...|::. |.|.|||..|:      .....|.||
pombe   273 -SEEELILWGY-NIGD---------VAPVNPPDEL-RECDRCGTRFA------DPRGPCTYH--- 316

  Fly   774 TGYRRGFTDHQ-------HRCCQQPAG-TPGCTYANYHVSDY-------------YDPEKLTCFV 817
              :.:.|.:.|       :.||....| :.||...:.||..|             |.|:....
pombe   317 --WGKLFREKQGGEKIRTYTCCGVKEGDSSGCIIEDNHVFKYRHLPYLASVHPFSYLPDSTNS-- 377

  Fly   818 KTIERGEEFVPTKKDIYALDCEMCYTTHGIELTRVTVVDINGRSVYDALVKPDNQIVDYNTTYSG 882
            |.:..           .|||||:||||:|:||.|:||| .....:.|..:||..:|:..||.:||
pombe   378 KQLSH-----------CALDCELCYTTNGMELARLTVV-AKESIIMDVFIKPKGKILSLNTRFSG 430

  Fly   883 ITEAMLSNETRTIRDVQAVLMSM-FHAKTVLVGHSLESDLKALKLIHDVVVDTSVLFPHKMGPPK 946
            |.:|.......|:..:...:..: .:..|:|:||.||:||.|::|||..|:||::||.|..|||.
pombe   431 IHDAKELESGITMDQMYIKIKELGMNKNTILIGHGLENDLNAMRLIHKRVIDTALLFTHARGPPF 495

  Fly   947 KRALKTLCIENLKRIIQESEAGHDSAEDAEVCIQLIKYYLRNKIS 991
            :.:||.|..:.|...||.|.  |||.|||...:||:.|..::..|
pombe   496 RYSLKYLTKKYLGTTIQTST--HDSEEDAVSALQLVFYKTKSNES 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12877	NP_001034073.1	CDC45	129..>199	CDD:280821
		EloA-BP1	572..736	CDD:292495	24/173 (14%)
		REX1_like	834..983	CDD:99848	63/149 (42%)
		DnaQ	847..>991	CDD:223916	54/144 (38%)
rex3	NP_594715.1	REX1_like	384..530	CDD:99848	63/148 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002085
OrthoInspector	1	1.000	-	-		otm47092
orthoMCL	1	0.900	-	-		OOG6_103246
Panther	1	1.100	-	-	LDO	PTHR12801
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2254
SonicParanoid	1	1.000	-	-		X1541
TreeFam	0	0.000	Not matched by this tool.
	9	8.840