DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12877 and Isg20l2

DIOPT Version :9

Sequence 1:	NP_001034073.1	Gene:	CG12877 / 43333	FlyBaseID:	FBgn0039544	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_808331.1	Gene:	Isg20l2 / 229504	MGIID:	2140076	Length:	368	Species:	Mus musculus

Alignment Length:	371	Identity:	91/371 - (24%)
Similarity:	140/371 - (37%)	Gaps:	91/371 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   661 HEMMLGGKRALTTSWSVEKK----GKLSSLGNGEP------------FDALDAEKAYKMVFDLRL 709
            |:..:..:|.|.....:.||    .|:|.| |.||            ...|...|..:.....|.
Mouse    24 HQRFVKKRRFLEQKGFLNKKNQPPNKVSKL-NSEPPKKGETSRVDGILKILPCPKKKEAAASKRD 87

  Fly   710 TEEQLVENG-----YPRPGDKRGSAV--------IRACRPNRRPNQKE--RYCSRCGKVFSLDIY 759
            :|:...:..     .|.|..|..|.|        .::..|..:..||:  :..|...|:.:.:..
Mouse    88 SEQSKDKKAPLSWLTPAPSKKTASVVSKIDLLGEFQSALPKTKSTQKKGSKKKSLKKKIATENST 152

  Fly   760 EHQSFD--------MCNYHPKSTGYRRGFTDHQHRCCQQPAGTPGCTYANYHVSDYYDPEKLTCF 816
            :.||.|        ..|..|.||..|     .:.:|...|...||
Mouse   153 QAQSKDKGSKKKPLKKNAVPNSTQAR-----SEDKCPTVPQNLPG-------------------- 192

  Fly   817 VKTIERGEEFVPTKKDIYALDCEMCYT---THGIELTRVTVVDINGRSVYDALVKPDNQIVDYNT 878
                           .:.|:||||..|   .....|.|.::|:.||..:||..|.|...||:|.|
Mouse   193 ---------------KMVAIDCEMVGTGPKGRVSSLARCSIVNYNGDVLYDEYVLPPCYIVNYRT 242

  Fly   879 TYSGITEAMLSNETRTIRDVQAVLMSMFHAKTVLVGHSLESDLKALKLIH--DVVVDTS--VLFP 939
            .:|||.:..:.|.| ..:..::.::.:...| |::||::.:|.|||:..|  .:..|||  .|..
Mouse   243 RWSGIRKCHMVNAT-PFKTARSQILKILSGK-VVIGHAIHNDYKALQYFHPKSLTRDTSRIPLLN 305

  Fly   940 HKMGPPKK--RALKTLCIENLKRIIQESEAGHDSAEDAEVCIQLIK 983
            .|...|:.  .:||.|..:.|.|.||....||.|.|||:..::|.|
Mouse   306 RKADCPENVTLSLKHLTKKLLSRDIQVGNTGHSSVEDAQATMELYK 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12877	NP_001034073.1	CDC45	129..>199	CDD:280821
		EloA-BP1	572..736	CDD:292495	20/103 (19%)
		REX1_like	834..983	CDD:99848	53/157 (34%)
		DnaQ	847..>991	CDD:223916	48/143 (34%)
Isg20l2	NP_808331.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..107		15/74 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..187		14/64 (22%)
		ISG20	195..351	CDD:99852	53/157 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845402
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740