DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CROT and crot

DIOPT Version :9

Sequence 1:	NP_001334704.1	Gene:	CROT / 43332	FlyBaseID:	FBgn0039543	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_001018161.1	Gene:	crot / 553204	ZFINID:	ZDB-GENE-050522-35	Length:	612	Species:	Danio rerio

Alignment Length:	608	Identity:	207/608 - (34%)
Similarity:	323/608 - (53%)	Gaps:	24/608 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KNTFDFDETLPSLPLPELRDTMERYYSCIQPFGTKEELAQARKTIDEFQNGVGAQLHEQLKKRAA 78
            :.||.:..:||.||:|.||||:.:|...::||.::||.......:..|:.|:|.:||::|.:||.
Zfish    11 ERTFQYQRSLPPLPVPALRDTLSKYLDAVKPFASEEEFGATVAIVKRFEEGIGQELHQKLLQRAK 75

  Fly    79 GMRNWLGTWWEDYGYHLIRMPLLPYQLMV----MPSQLEMVGVPETPEYMLKSLARHIHHSLEFW 139
            ..||||..||.|..|..:|   :|.||.|    ..:.||....|:... .|:..:..:..:.:.|
Zfish    76 SKRNWLEEWWLDTAYLEVR---IPSQLNVNFGGPTAYLEHCWPPQEGT-QLERTSMVLWLTFQCW 136

  Fly   140 DLTRKSSIKPLSSNGGKIKYSSALYKHFFSTCRVPGEEQDHIEKHFLTKDEGKTPSHMLISGKGR 204
            ||.|...:  .....|.|.:....::..|.||:|||..:|.|...|.|:.||..|||:::..:||
Zfish   137 DLIRTERL--AIHKAGTIPFDMDQFRMLFCTCKVPGITKDTILNFFKTESEGPCPSHVIVMCRGR 199

  Fly   205 QFIFDCVHEDDTILSAPEILVALQRVRSILDYEPLGDCVPTLSHDERSTWARNRNRLREISVANK 269
            .|.||.:. |..||:.||:|..|..:::..|.||.||.|..|:.:||:.||:.|..|..:...||
Zfish   200 IFTFDALC-DGRILTPPELLRQLTYIKNCCDGEPEGDGVSALTTEERTRWAKAREYLISMDPVNK 263

  Fly   270 ETLLLVESACMEICWYE----QSPKDYEESCQLGLYGDLHSRWADRSSSIIAFRNGRCNWTGEHS 330
            ..|..::||...:...:    .:|.:|.:...|.|.||..:||.|:|.:::.:.||..:...:|:
Zfish   264 TILETIQSALFVVGLDDAKPYATPDNYTQLTDLALTGDPTNRWGDKSYNLVCYSNGIFSSNCDHA 328

  Fly   331 CYDGTVSISYATFMQLSFLEVPEPDWAEAEKGNVLEV-KELHFQLDDTLKNEIKRVQKDIDDRGI 394
            .||..|.:|...::... |:.....|...|....:.| :||.|.:|:.::.:|...::.......
Zfish   329 PYDAMVLVSNGYYVDQK-LKACGGVWKGLEVVRQMPVPEELIFTVDERVRRDIALAKEQYSKSCQ 392

  Fly   395 DVTVTFTAFDDYGKDFMKTHRLHPDSFVQVVMQWAYYQMHKEIAPTYETALMRQYYNGRTETLRS 459
            |:.|...||..:||..:|..:||||:|||:.:|.|||:.|.:....||||..|::::|||||:|.
Zfish   393 DLQVVSYAFTSFGKTAIKKRKLHPDTFVQLALQLAYYRQHGQPGCCYETATTRRFFHGRTETMRP 457

  Fly   460 CTSAVAEFLRASSNKQVGDMSLARAFRRAVDEHKHFMNEARKGHGIDRHLFGLWCAAYESKMDIP 524
            ||.....:.|...|..............||::|...|.||:.|.||||||.||:..|.|:.:.:|
Zfish   458 CTMEAQHWCRTMMNPAATTEEKRHTLHAAVNKHNKLMAEAQDGKGIDRHLLGLYLIAKENSIPVP 522

  Fly   525 AFYDDPMYTKSGGGGNFVLSSSTLGFTANVGFVAPMVFDGYGVFYSITSEAVFINTTAYRDSLKT 589
            ..|.||:|||||||||||||:|.:|:|..:|.|||||..|||.||.|..:.:..:.||::.:.:|
Zfish   523 ELYADPLYTKSGGGGNFVLSTSLVGYTTVLGAVAPMVPHGYGFFYRIRDDRIVASCTAWKSNPET 587

  Fly   590 SARKFNDIFKDSFRRISVLLEQL 612
            .|...       |:.::..|.::
Zfish   588 DAETL-------FQNLATSLHEM 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CROT	NP_001334704.1	None
crot	NP_001018161.1	Carn_acyltransf	20..604	CDD:279140	205/599 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594981
Domainoid	1	1.000	357	1.000	Domainoid score	I937
eggNOG	1	0.900	-	-		E1_KOG3718
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10899
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2149
OMA	1	1.010	-	-		QHG49249
OrthoDB	1	1.010	-	-		D167256at33208
OrthoFinder	1	1.000	-	-		FOG0006330
OrthoInspector	1	1.000	-	-		oto41686
orthoMCL	1	0.900	-	-		OOG6_107213
Panther	1	1.100	-	-	LDO	PTHR22589
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4410
SonicParanoid	1	1.000	-	-		X4606
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800