DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CROT and Chat

DIOPT Version :9

Sequence 1:	NP_001334704.1	Gene:	CROT / 43332	FlyBaseID:	FBgn0039543	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_001164064.1	Gene:	Chat / 290567	RGDID:	1304627	Length:	644	Species:	Rattus norvegicus

Alignment Length:	625	Identity:	157/625 - (25%)
Similarity:	276/625 - (44%)	Gaps:	101/625 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LPSLPLPELRDTMERYYSCIQPFGTKEELAQARKTIDEF--QNGVGAQLHEQLKKRAAGMRNWLG 85
            ||.||:|.|:.|:..|..|:|....:|:..:::..:..|  ..|:|..|.|:|.:|.....||:.
  Rat    23 LPKLPVPPLQQTLATYLQCMQHLVPEEQFRKSQAIVKRFGAPGGLGETLQEKLLERQEKTANWVS 87

  Fly    86 TWW--EDYGYHLIRMPLLPYQLMVMPSQLEMVGVPETPEYMLKSLARHIHHSLEFWDLTRKSSIK 148
            .:|  :.|..:.:.:|:.....::...|    ...:|.: .|:..|..|...|.:..|....|:
  Rat    88 EYWLNDMYLNNRLALPVNSSPAVIFARQ----HFQDTND-QLRFAACLISGVLSYKTLLDSHSL- 146

  Fly   149 PLSSNGGKIKYSSALYKHF---FSTCRVPGEEQDHI--EKHFLTKDEGKTPSHMLISGKGRQFIF 208
            |.....|::.......|.:   ||:.|:||..||.:  :|..:..:    |.|::::...:.|:.
  Rat   147 PTDWAKGQLSGQPLCMKQYYRLFSSYRLPGHTQDTLVAQKSSIMPE----PEHVIVACCNQFFVL 207

  Fly   209 DCVHEDDTILSAPEILVALQRVRSILDYE-----PLGDCVPTLSHDERSTWARNRNRLREISVAN 268
            |.| .:...||..::...|:::..:...|     |:|    .|:.|.||.||:.|..|.:.| .|
  Rat   208 DVV-INFRRLSEGDLFTQLRKIVKMASNEDERLPPIG----LLTSDGRSEWAKARTVLLKDS-TN 266

  Fly   269 KETLLLVESACMEICWYEQSP-----KDYEESCQLGLYGDLH---------SRWADRSSSIIAFR 319
            :::|.::|.....:|.  ..|     .|...:.||     ||         :||.|:|...:..|
  Rat   267 RDSLDMIERCICLVCL--DGPGTGELSDTHRALQL-----LHGGGCSLNGANRWYDKSLQFVVGR 324

  Fly   320 NGRCNWTGEHSCYDGTVSISYATFMQL-------------SFLEVPEP---DW--AEAEKGNVLE 366
            :|.|....|||.:||.|.:.....:..             |..|:|.|   .|  :...:|::..
  Rat   325 DGTCGVVCEHSPFDGIVLVQCTEHLLKHMMTSNKKLVRADSVSELPAPRRLRWKCSPETQGHLAS 389

  Fly   367 VKELHFQLDDTLKNEIKRVQKDIDDRGIDVTVTFTAFDDYGKDFMKTHRLHPDSFVQVVMQWAYY 431
            ..|           :::|:.|::|       .....||:|||.|:|..:..||.|:||.:|.|||
  Rat   390 SAE-----------KLQRIVKNLD-------FIVYKFDNYGKTFIKKQKYSPDGFIQVALQLAYY 436

  Fly   432 QMHKEIAPTYETALMRQYYNGRTETLRSCTSAVAEFLRASSNKQVG-----DMSLARAFRRAVDE 491
            ::::.:.||||:|.:|::..||.:.:||.|.....|::|.::.:..     .:.|.:...:|..|
  Rat   437 RLYQRLVPTYESASIRRFQEGRVDNIRSATPEALAFVQAMTDHKAAMPASEKLQLLQTAMQAQTE 501

  Fly   492 HKHFMNEARKGHGIDRHLFGLWCAAYESKMDIPAFYDDPMYTKSGGGGNFVLSSSTLGFTANVGF 556
            :...   |..|..||.||..|...|.:...:.|..:.|..|..|   ..||||:|.:..|..: |
  Rat   502 YTVM---AITGMAIDNHLLALRELARDLCKEPPEMFMDETYLMS---NRFVLSTSQVPTTMEM-F 559

  Fly   557 --VAPMVFDGYGVFYSITSEAVFINTTAYRDSLKTSARKF 594
              ..|:|.:|||..|:...||:....:::....:||:.:|
  Rat   560 CCYGPVVPNGYGACYNPQPEAITFCISSFHSCKETSSVEF 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CROT	NP_001334704.1	None
Chat	NP_001164064.1	Carn_acyltransf	23..611	CDD:395612	157/625 (25%)
Chat	NP_001164064.1	Coenzyme A binding. /evidence=ECO:0000305	412..424		4/11 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167256at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920