DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CROT and Cpt2

DIOPT Version :9

Sequence 1:	NP_001334704.1	Gene:	CROT / 43332	FlyBaseID:	FBgn0039543	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_037062.1	Gene:	Cpt2 / 25413	RGDID:	2398	Length:	658	Species:	Rattus norvegicus

Alignment Length:	637	Identity:	167/637 - (26%)
Similarity:	270/637 - (42%)	Gaps:	84/637 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TFDFDETLPSLPLPELRDTMERYYSCIQPFGTKEELAQARKTIDEFQNGVGAQLHEQL---KKRA 77
            |..:.::||.||:|:|.|||:||.:..:|.....:..:.......|:.|||.:||..|   .|:.
  Rat    42 TMHYQDSLPRLPIPKLEDTMKRYLNAQKPLLDDSQFRRTEALCKNFETGVGKELHAHLLAQDKQN 106

  Fly    78 AGMRNWLGTWWE-------------------------DYGYHLIRMPLLPYQLMVMPSQLEMVGV 117
            .......|.|::                         :|...|.|...|....:.....|: .|:
  Rat   107 KHTSYISGPWFDMYLTARDSIVLNFNPFMAFNPDPKSEYNDQLTRATNLTVSAVRFLKTLQ-AGL 170

  Fly   118 PETPEYML----------KSLARHIHHSLEFWDLTRKSSIKPLSSNGGKIKYSSALYKHFFSTCR 172
            .|...:.|          |.|.|.:..||. |......:..||         ..:.|...|::.|
  Rat   171 LEPEVFHLNPSKSDTDAFKRLIRFVPPSLS-WYGAYLVNAYPL---------DMSQYFRLFNSTR 225

  Fly   173 VPGEEQDHIEKHFLTKDEGKTPSHMLISGKGRQFIFDCVHEDDTILSAPEILVALQRVRSILDYE 237
            :|...:|.:    .|..:.:   |:|:..||..::||.:.:|..|::..||...|:.:.|  |..
  Rat   226 IPRPNRDEL----FTDTKAR---HLLVLRKGHFYVFDVLDQDGNIVNPLEIQAHLKYILS--DSS 281

  Fly   238 PLGDC-VPTLSHDERSTWARNRNRLREISVANKETLLLVESACMEICWYEQSPKDYEESCQLGLY 301
            |:.:. |..|:.:.|..||..|.:|  |...|:|||..|:||...:|..:...||........|:
  Rat   282 PVPEFPVAYLTSENRDVWAELRQKL--IFDGNEETLKKVDSAVFCLCLDDFPMKDLIHLSHTMLH 344

  Fly   302 GDLHSRWADRSSSIIAFRNGRCNWTGEHSCYDGTVSISYATFMQLSFLEVP--EPDWAEAEKGNV 364
            ||..:||.|:|.::|...:|......|||..||...:.:...:.....:.|  .|....|...:.
  Rat   345 GDGTNRWFDKSFNLIVAEDGTAAVHFEHSWGDGVAVLRFFNEVFRDSTQTPAITPQSQPAATNSS 409

  Fly   365 LEVKELHFQLDDTLKNEIKRVQKDIDDRGIDVTVTFTAFDDYGKDFMKTHRLHPDSFVQVVMQWA 429
            ..|:.|.|.|...||..|...::..|.....:::....|...||:|:|..:|.||:..|:..|.|
  Rat   410 ASVETLSFNLSGALKAGITAAKEKFDTTVKTLSIDSIQFQRGGKEFLKKKQLSPDAVAQLAFQMA 474

  Fly   430 YYQMHKEIAPTYETALMRQYYNGRTETLR-------SCTSAVAEFLRASSNKQVGDMSLARAFRR 487
            :.:.:.:...|||:.....:.:|||||:|       .|:.|   |:|..|...||:  |......
  Rat   475 FLRQYGQTVATYESCSTAAFKHGRTETIRPASIFTKRCSEA---FVRDPSKHSVGE--LQHMMAE 534

  Fly   488 AVDEHKHFMNEARKGHGIDRHLFGLWCAAYESKMDIPAFYDDPMYTKSGGGGNFVLSSSTLGFTA 552
            ....|.....||..|.|.||||:.|...|....:::|..|.||.|.:.   .:.:||:|||...|
  Rat   535 CSKYHGQLTKEAAMGQGFDRHLYALRYLATARGLNLPELYLDPAYQQM---NHNILSTSTLNSPA 596

  Fly   553 -NVGFVAPMVFDGYGVFYSITSEAVFINTTAY-----RDSLKTSARKFNDIF 598
             ::|..||:|.||:|:.|::..:.:..|.::|     |:.|....:...|||
  Rat   597 VSLGGFAPVVPDGFGIAYAVHDDWIGCNVSSYSGRNAREFLHCVQKCLEDIF 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CROT	NP_001334704.1	None
Cpt2	NP_037062.1	Carn_acyltransf	49..648	CDD:279140	164/628 (26%)
Cpt2	NP_037062.1	Coenzyme A binding. /evidence=ECO:0000250	452..464		5/11 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167256at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920