DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CROT and CPT1A

DIOPT Version :9

Sequence 1:	NP_001334704.1	Gene:	CROT / 43332	FlyBaseID:	FBgn0039543	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	XP_005273819.1	Gene:	CPT1A / 1374	HGNCID:	2328	Length:	805	Species:	Homo sapiens

Alignment Length:	697	Identity:	186/697 - (26%)
Similarity:	291/697 - (41%)	Gaps:	147/697 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDRASLYFM------SKDDKNTFDFDETLPSLPLPELRDTMERYYSCIQPFGTKEELAQARKTID 59
            |.||:..:|      |......:.|..:||.||:|.::||:.||...::|...:|:..:......
Human   175 MSRATKIWMGMVKIFSGRKPMLYSFQTSLPRLPVPAVKDTVNRYLQSVRPLMKEEDFKRMTALAQ 239

  Fly    60 EFQNGVGAQLHEQLKKRAAGMRNWLGTWWEDYGYHLIRMPLLPYQ-------LMVMPSQLEMVGV 117
            :|..|:|.:|...||.::....|::..|||:|.|...|.||:...       |.::|:.::..
Human   240 DFAVGLGPRLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMDLLYILPTHIQAA-- 302

  Fly   118 PETPEYMLKSLARHIHHSLEFWDLTRKSSIKPLSSNGGKIKYSSALYKHFFSTCRVPGEEQDHIE 182
                     .....||..|.:.....:..|||:...|..|...||.::..|:|.|:||||.|.|:
Human   303 ---------RAGNAIHAILLYRRKLDREEIKPIRLLGSTIPLCSAQWERMFNTSRIPGEETDTIQ 358

  Fly   183 KHFLTKDEGKTPSHMLISGKGRQFIFDCVHEDDTILSAPEILVALQRVRSILD--YEPL-GDC-V 243
             |.      :...|:::..:||.|.....| |..:|...|:...:||   |||  .||. |:. :
Human   359 -HM------RDSKHIVVYHRGRYFKVWLYH-DGRLLKPREMEQQMQR---ILDNTSEPQPGEARL 412

  Fly   244 PTLSHDERSTWARNR----NRLREISVANKETLLLVESACMEICWYE-----------QSPKDYE 293
            ..|:..:|..|||.|    .|.:     ||::|..||.|...:...|           .|...|.
Human   413 AALTAGDRVPWARCRQAYFGRGK-----NKQSLDAVEKAAFFVTLDETEEGYRSEDPDTSMDSYA 472

  Fly   294 ESCQLGLYGDLHSRWADRSSSIIAFRNGRCNWTGEHSCYDGTV------SISYATFMQLSFLE-- 350
            :|.   |:|..:.||.|:|.:.:.|:||:.....|||..|..:      .:.....:||.:.|
Human   473 KSL---LHGRCYDRWFDKSFTFVVFKNGKMGLNAEHSWADAPIVAHLWEYVMSIDSLQLGYAEDG 534

  Fly   351 ---------VPEPDWAEAE-KGNVLEVKELHFQLDDTLKNEIKRVQKDIDDRGIDVTVTFTAFDD 405
                     :|.|...:.: .|...||.|......:.|.|       |:|..    :..|.||
Human   535 HCKGDINPNIPYPTRLQWDIPGECQEVIETSLNTANLLAN-------DVDFH----SFPFVAF-- 586

  Fly   406 YGKDFMKTHRLHPDSFVQVVMQWAYYQMHKEIAPTYETALMRQYYNGRTETLRSCTSAVAEFLRA 470
             ||..:|..|..||:|||:.:|.|:|:...:...|||.::.|.:..|||||:||||:...:|:||
Human   587 -GKGIIKKCRTSPDAFVQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTTESCDFVRA 650

  Fly   471 SSNKQVGDMSLARAFRRAVDEHKHFMNEARKGHGIDRHLFGLWCA----AYES------------ 519
            ..:.........:.|:.|.::|:|....|..|.|||||||.|:..    |.||
Human   651 MVDPAQTVEQRLKLFKLASEKHQHMYRLAMTGSGIDRHLFCLYVVSKYLAVESPFLKEVLSEPWR 715

  Fly   520 ---------KMDIPAFYDDPMYTKSGGGGNFVLSSSTLGFTANVGFVAPMVFDGYGVFYSITSEA 575
                     ::::....::|.|..||||                  ..|:..|||||.|.:..|
Human   716 LSTSQTPQQQVELFDLENNPEYVSSGGG------------------FGPVADDGYGVSYILVGE- 761

  Fly   576 VFINTTAYRDSLK-----TSARKFNDIFKDSFRRISVLLEQLAKESK 617
               |...:..|.|     |.:.:|....|::...| :.|..|:..||
Human   762 ---NLINFHISSKFSCPETDSHRFGRHLKEAMTDI-ITLFGLSSNSK 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CROT	NP_001334704.1	None
CPT1A	XP_005273819.1	CPT_N	33..78	CDD:293093
CPT1A	XP_005273819.1	Carn_acyltransf	203..793	CDD:279140	175/655 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920