DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CROT and Chat

DIOPT Version :9

Sequence 1:	NP_001334704.1	Gene:	CROT / 43332	FlyBaseID:	FBgn0039543	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_034021.1	Gene:	Chat / 12647	MGIID:	88392	Length:	645	Species:	Mus musculus

Alignment Length:	622	Identity:	156/622 - (25%)
Similarity:	277/622 - (44%)	Gaps:	95/622 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LPSLPLPELRDTMERYYSCIQPFGTKEELAQARKTIDEF--QNGVGAQLHEQLKKRAAGMRNWLG 85
            ||.||:|.|:.|:..|..|:|....:|:..:::..:..|  ..|:|..|.|:|.:|.....||:.
Mouse    24 LPKLPVPPLQQTLATYLQCMQHLVPEEQFRKSQAIVKRFGAPGGLGETLQEKLLERQEKTANWVS 88

  Fly    86 TWW--EDYGYHLIRMPLLPYQLMVMPSQLEMVGVPETPEYMLKSLARHIHHSLEFWDLTRKSSIK 148
            .:|  :.|..:.:.:|:.....::...|    ...:|.: .|:..|..|...|.:..|....||
Mouse    89 EYWLNDMYLNNRLALPVNSSPAVIFARQ----HFQDTND-QLRFAASLISGVLSYKALLDSQSI- 147

  Fly   149 PLSSNGGKIKYSSALYKHF---FSTCRVPGEEQDHI--EKHFLTKDEGKTPSHMLISGKGRQFIF 208
            |.....|::.......|.:   ||:.|:||..||.:  :|..:..:    |.|::::...:.|:.
Mouse   148 PTDWAKGQLSGQPLCMKQYYRLFSSYRLPGHTQDTLVAQKSSIMPE----PEHVIVACCNQFFVL 208

  Fly   209 DCVHEDDTILSAPEILVALQRVRSILDYE-----PLGDCVPTLSHDERSTWARNRNRLREISVAN 268
            |.| .:...||..::...|:::..:...|     |:|    .|:.|.||.||:.|..|.:.| .|
Mouse   209 DVV-INFRRLSEGDLFTQLRKIVKMASNEDERLPPIG----LLTSDGRSEWAKARTVLLKDS-TN 267

  Fly   269 KETLLLVESACMEICWYEQSP-----KDYEESCQLGLYGDLH---------SRWADRSSSIIAFR 319
            :::|.::|.....:|.  ..|     .|...:.||     ||         :||.|:|...:..|
Mouse   268 RDSLDMIERCICLVCL--DGPGTGDLSDTHRALQL-----LHGGGCSLNGANRWYDKSLQFVVGR 325

  Fly   320 NGRCNWTGEHSCYDGTVSISYATFMQL-------------SFLEVPEP---DW--AEAEKGNVLE 366
            :|.|....|||.:||.|.:.....:..             |..|:|.|   .|  :...:|::..
Mouse   326 DGTCGVVCEHSPFDGIVLVQCTEHLLKHMMTGNKKLVRADSVSELPAPRRLRWKCSPETQGHLAS 390

  Fly   367 VKELHFQLDDTLKNEIKRVQKDIDDRGIDVTVTFTAFDDYGKDFMKTHRLHPDSFVQVVMQWAYY 431
            ..|           :::|:.|::|       .....||:|||.|:|..:..||.|:||.:|.|||
Mouse   391 SAE-----------KLQRIVKNLD-------FIVYKFDNYGKTFIKKQKCSPDGFIQVALQLAYY 437

  Fly   432 QMHKEIAPTYETALMRQYYNGRTETLRSCTSAVAEFLRASSNKQVGDMSLAR--AFRRAVDEHKH 494
            ::::.:.||||:|.:|::..||.:.:||.|.....|::|.::.:...::..:  ..:||:.....
Mouse   438 RLYQRLVPTYESASIRRFQEGRVDNIRSATPEALAFVQAMTDHKAAVLASEKLQLLQRAIQAQTE 502

  Fly   495 FMNEARKGHGIDRHLFGLWCAAYESKMDIPAFYDDPMYTKSGGGGNFVLSSSTLGFTANVGF--V 557
            :...|..|..||.||..|...|.:...:.|..:.|..|..|   ..|:||:|.:..|..: |  .
Mouse   503 YTVMAITGMAIDNHLLALRELARDLCKEPPEMFMDETYLMS---NRFILSTSQVPTTMEM-FCCY 563

  Fly   558 APMVFDGYGVFYSITSEAVFINTTAYRDSLKTSARKF 594
            .|:|.:|||..|:...||:....:::....:||:.:|
Mouse   564 GPVVPNGYGACYNPQPEAITFCISSFHGCKETSSVEF 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CROT	NP_001334704.1	None
Chat	NP_034021.1	Carn_acyltransf	24..612	CDD:279140	156/622 (25%)
Chat	NP_034021.1	Coenzyme A binding. /evidence=ECO:0000250	413..425		4/11 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167256at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920