Protein Alignment CROT and CPT1C

DIOPT Version :10

• Sequence 1: NP_733230.1
• Gene: CROT / 43332
• FlyBaseID: FBgn0039543
• Length: 618
• Species: Drosophila melanogaster
• Sequence 2: NP_001365411.1
• Gene: CPT1C / 126129
• HGNCID: 18540
• Length: 825
• Species: Homo sapiens
• Alignment Length: 674
• Identity: 161/674 - (23%)
• Similarity: 272/674 - (40%)
• Gaps: 133/674 - (19%)

  Fly    17 FDFDETLPSLPLPELRDTMERYYSCIQPFGTKEELAQARKTIDEFQNGVGAQLHEQLKKRAAGMR 81
            |.:..:||..|:|.::||:.:|...::|..:.|:.........||.....:.|...|:.::....
Human   165 FSYQRSLPRQPVPSVQDTVRKYLESVRPILSDEDFDWTAVLAQEFLRLQASLLQWYLRLKSWWAS 229

  Fly    82 NWLGTWWEDYGYHLIRMPLL---------------PYQLMVMPSQLEMVGVPET--PEYMLKSLA 129
            |::..|||::.|...|.||:               .:.|::...:|....:|..  |:::...
Human   230 NYVSDWWEEFVYLRSRNPLMVNSNYYMMAARAGNAVHALLLYRHRLNRQEIPPVRGPQWVRDG-- 292

  Fly   130 RHIHHSLEFWDLTRKSSIKPLSSNG-------GKIKYSSALYKHFFSTCRVPGEEQDHIEKHFLT 187
                 .:..|.|......:.|:::|       |.....||.|:..|:|.|:||.::|:| :|.
Human   293 -----GVVLWPLGHVGPGRQLTAHGFLQTLLMGMRPLCSAQYEKIFNTTRIPGVQKDYI-RHL-- 349

  Fly   188 KDEGKTPSHMLISGKGRQFIFDCVHEDDTILSAPEILVALQRVRSILDYEPLGDCVPTLSHDE-- 250
                ....|:.:..:||.|... .|..:::||...:....||:        |.|..|...|:|
Human   350 ----HDSQHVAVFHRGRFFRMG-THSRNSLLSPRALEQQFQRI--------LDDPSPACPHEEHL 401

  Fly   251 -------RSTWARNRNRLREISVANKETLLLVESACMEICWYEQSPKDY---EESCQLGLY---- 301
                   |.|||:.|..|:..:.   |.|..||.|...:. .:..|...   :.:..|..|
Human   402 AALTAAPRGTWAQVRTSLKTQAA---EALEAVEGAAFFVS-LDAEPAGLTREDPAASLDAYAHAL 462

  Fly   302 --GDLHSRWADRSSSIIAFRNGRCNWTGEHSCYDGTVS-----ISYAT-FMQLSFLE------VP 352
              |..|.||.|:|.::|.|.||:...:.|||..|..:|     .:.|| ..||.:..      .|
Human   463 LAGRGHDRWFDKSFTLIVFSNGKLGLSVEHSWADCPISGHMWEFTLATECFQLGYSTDGHCKGHP 527

  Fly   353 EPDWAEAEKGNVLEVKELHFQLDDTLKNEIKRVQKDIDDRGIDVTVTFTAFDDYGKDFMKTHRLH 417
            :|...:.::        |.:.|.|.:.:.|....:.......:|......|..:||.|::...|.
Human   528 DPTLPQPQR--------LQWDLPDQIHSSISLALRGAKILSENVDCHVVPFSLFGKSFIRRCHLS 584

  Fly   418 PDSFVQVVMQWAYYQMHKEIAPTYETALMRQYYNGRTETLRSCTSAVAEFLRASSNKQVGDMSLA 482
            .|||:|:.:|.|:::...:...|||:|:.|.:..|||||:||||.....|:||..:|:..|....
Human   585 SDSFIQIALQLAHFRDRGQFCLTYESAMTRLFLEGRTETVRSCTREACNFVRAMEDKEKTDPQCL 649

  Fly   483 RAFRRAVDEHKHFMNEARKGHGIDRHLFGLWCAA------------------YESKMDIPA---- 525
            ..||.|||:|:..:..|..|.|:|||||.|:..:                  ..|...||.
Human   650 ALFRVAVDKHQALLKAAMSGQGVDRHLFALYIVSRFLHLQSPFLTQVHSEQWQLSTSQIPVQQMH 714

  Fly   526 ---FYDDPMYTKSGGGGNFVLSSSTLGFTANVGFVAPMVFDGYGVFYSITSEA-VFINTTAYRDS 586
               .::.|.|..||||                  ..|....||||.|....:. :..:.::.:.|
Human   715 LFDVHNYPDYVSSGGG------------------FGPADDHGYGVSYIFMGDGMITFHISSKKSS 761

  Fly   587 LKTSARKFNDIFKDSFRRISVLLE 610
            .||.:.:.....:|:...::.|.:
Human   762 TKTDSHRLGQHIEDALLDVASLFQ 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CROT	NP_733230.1	Carn_acyltransf	26..594	CDD:459926	156/647 (24%)
CPT1C	NP_001365411.1	CPT_N	1..47	CDD:465132
		Carn_acyltransf	174..775	CDD:459926	156/653 (24%)