DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CROT and CHAT

DIOPT Version :9

Sequence 1:	NP_001334704.1	Gene:	CROT / 43332	FlyBaseID:	FBgn0039543	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_065574.4	Gene:	CHAT / 1103	HGNCID:	1912	Length:	748	Species:	Homo sapiens

Alignment Length:	645	Identity:	160/645 - (24%)
Similarity:	278/645 - (43%)	Gaps:	127/645 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LPSLPLPELRDTMERYYSCIQPFGTKEELAQARKTIDEF--QNGVGAQLHEQLKKRAAGMRNWLG 85
            ||.||:|.|:.|:..|..|::...::|:..:::..:.:|  ..|:|..|.::|.:|.....||:.
Human   131 LPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVS 195

  Fly    86 TWW--EDYGYHLIRMPLLPYQLMVMPSQLEMVGVPETPEYMLKSLARHIHHSLEFWDLTRKSSIK 148
            .:|  :.|..:.:.:|:.....::...|    ..|.|.: .|:..|..|...|.:..|....||
Human   196 EYWLNDMYLNNRLALPVNSSPAVIFARQ----HFPGTDD-QLRFAASLISGVLSYKALLDSHSI- 254

  Fly   149 PLSSNGGKIKYSSALYKHF---FSTCRVPGEEQDHIEKHFLTKDEG--KTPSHMLISGKGRQFIF 208
            |.....|::.......|.:   ||:.|:||..||.:    :.::..  ..|.|::::...:.|:.
Human   255 PTDCAKGQLSGQPLCMKQYYGLFSSYRLPGHTQDTL----VAQNSSIMPEPEHVIVACCNQFFVL 315

  Fly   209 DCVHEDDTILSAPEILVALQRVRSILDYE-----PLGDCVPTLSHDERSTWARNRNRLREISVAN 268
            |.| .:...||..::...|:::..:...|     |:|    .|:.|.||.||..|..|.:.| .|
Human   316 DVV-INFRRLSEGDLFTQLRKIVKMASNEDERLPPIG----LLTSDGRSEWAEARTVLVKDS-TN 374

  Fly   269 KETLLLVESACMEICWYEQSP-----KDYEESCQLGLYGDLHS-----RWADRSSSIIAFRNGRC 323
            :::|.::|.....:|.  .:|     .|...:.|| |:|..:|     ||.|:|...:..|:|.|
Human   375 RDSLDMIERCICLVCL--DAPGGVELSDTHRALQL-LHGGGYSKNGANRWYDKSLQFVVGRDGTC 436

  Fly   324 NWTGEHSCYDGTVSI-------------SYATFMQLSFLEVPEPDWAEAEKGNVLEVKELHFQLD 375
            ....|||.:||.|.:             |.......|..|:|.|             :.|.::..
Human   437 GVVCEHSPFDGIVLVQCTEHLLKHVTQSSRKLIRADSVSELPAP-------------RRLRWKCS 488

  Fly   376 DTLK-------NEIKRVQKDIDDRGIDVTVTFTAFDDYGKDFMKTHRLHPDSFVQVVMQWAYYQM 433
            ..::       .:::|:.|::|       .....||:|||.|:|..:..||:|:||.:|.|:|::
Human   489 PEIQGHLASSAEKLQRIVKNLD-------FIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRL 546

  Fly   434 HKEIAPTYETALMRQYYNGRTETLRSCTSAVAEFLRASSNKQVGDMSLARAFRRAVDEHKHFMNE 498
            |:.:.||||:|.:|::..||.:.:||.|..                  |.||.|||.:||..:..
Human   547 HRRLVPTYESASIRRFQEGRVDNIRSATPE------------------ALAFVRAVTDHKAAVPA 593

  Fly   499 ARK--------------------GHGIDRHLFGLWCAAYESKMDIPAFYDDPMYTKSGGGGNFVL 543
            :.|                    |..||.||..|...|.....::|..:.|..|..|   ..|||
Human   594 SEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCKELPEMFMDETYLMS---NRFVL 655

  Fly   544 SSSTLGFTANVGF--VAPMVFDGYGVFYSITSEAVFINTTAYRDSLKTSARKFNDIFKDS 601
            |:|.:..|..: |  ..|:|.:|||..|:...|.:....:::....:||:.||....::|
Human   656 STSQVPTTTEM-FCCYGPVVPNGYGACYNPQPETILFCISSFHSCKETSSSKFAKAVEES 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CROT	NP_001334704.1	None
CHAT	NP_065574.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..89
		PHA03247	<27..138	CDD:223021	4/6 (67%)
		Carn_acyltransf	131..719	CDD:395612	160/645 (25%)
		Coenzyme A binding	520..532		4/11 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	727..748
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167256at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920