back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btz and casc3

DIOPT Version :9

Sequence 1:	NP_001263028.1	Gene:	btz / 43331	FlyBaseID:	FBgn0045862	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_991279.1	Gene:	casc3 / 403025	ZFINID:	ZDB-GENE-040308-2	Length:	754	Species:	Danio rerio

Alignment Length:	818	Identity:	187/818 - (22%)
Similarity:	275/818 - (33%)	Gaps:	266/818 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 EPGTSPTQEPNSNSHPHD-------------SEYDTA------SDLEGGEDYDD-----EESASG 82
            ||..||.:...:.|....             |:||:|      |..||||:.::     ||.||.
Zfish    43 EPVESPAERVAAKSDDESECVSEDGVGEAVLSDYDSADLEENGSHTEGGEEEEEAERFSEEEASR 107

  Fly    83 SASGS------GSEEESETDDEDDEVGSETDDGEGEQAMDRSVAD------------SEAQK-KV 128
            .|:.|      .:||..|.::.|:.|.....|.:|..|.:|...|            |:.|| ..
Zfish   108 PAAESKPVADAPTEELVEGEERDESVKEVKADEKGNLAGERQSGDGQESTEDPENKGSKGQKLDD 172

  Fly   129 DEDRSNPQYIPKRGTFYEHDDRTAETEGEILIEPENGAGQAAAEPNGELNGLAAAGATPTGQTPQ 193
            ||||.||.|||::|.|:|||.|...||.|              .|.|
Zfish   173 DEDRKNPAYIPRKGLFFEHDVRGQATEEE--------------RPKG------------------ 205

  Fly   194 ISQASKTMRKWQPASGGDRWSHDRFEATEQAPKSRAELLQTYGYDIRNEDAPPRAR----RRRRY 254
                 :..:.|:...   ||.||:|...|||||||.||:..|||||||...|...|    |:.|:
Zfish   206 -----RNRKLWKDEG---RWEHDKFREEEQAPKSRDELIAFYGYDIRNGTGPSDGRSYRSRKPRH 262

  Fly   255 TRGPSKYSRNWEDEQAYLKASNKERKPPRPQDFPALNERKPRGPRTSSSREEKENRRSVAAEGLV 319
            ...||:..|.:.:....:: |:.:..||..::.|                           :.:.
Zfish   263 AGSPSREPRRYREGDKSVR-SSWQGPPPGHRNAP---------------------------QSVT 299

  Fly   320 PEKQQPLASSSNPHRSQERERERERERERDREPKNRNF--GRMNGGPGRQNGMEFKKNNRGQQLR 382
            .:..||||..|.|..|          .....:|..|:|  .|....|.|..|
Zfish   300 VQSGQPLAPLSAPKPS----------GRPSTQPPQRSFQGSRAPSAPHRTEG------------- 341

  Fly   383 ERERGPDQLDNRNQKPST-------PRSNQ---QQQPQQQPHHQQQPQQQRQPS---------QP 428
               |||       .|||.       |||..   ::.|:.:..........|.||         :.
Zfish   342 ---RGP-------SKPSLDGAPLRGPRSQPVEGERGPRLRGRSSHAVHADRSPSLVVEDICSEEE 396

  Fly   429 QQSPQTPLSTSNLSQRLQQVQQRNDPSHVGSVQMHSLASQNQAPQQQQQQPLHQEQRNAPKRYSS 493
            ::..:.|.:|:..:....:.::...||.........:...:.|.|.::..| .||::...|.||.
Zfish   397 EEEGEIPTATTTYTAHHYKTEKERVPSPRKQDSGMVMEGGSAAGQVRELSP-PQERQVEKKSYSR 460

  Fly   494 LRRSQQEASQHLAEQ----------QQQQMQQQLHLQQQQQQQQSQIMI---------------- 532
            .||:.:.....|::|          ||..:..:....|:|.:..:|..:
Zfish   461 ARRATRTRPSDLSKQASLDDSSSAVQQAPVAAKSESWQEQSEAGTQSGLTGLDQDLARLSLTGQN 525

  Fly   533 --QDPHVLMQIAYQQQELQAQLQTMQL--GPPTAAG--------------------AVPTPPKPH 573
              |:|.     :|.|.|::....:|.:  |||....                    .||.|...|
Zfish   526 WAQNPP-----SYLQAEMRGIRGSMHMAGGPPQYGNMEDMGVGGGRAKRYSSQRQRPVPEPAPMH 585

  Fly   574 APPAAAY---PQAQAAPYYVTGTEPVPVPVPQAPYVNPASAAYLPTTPAAVAYAQAG-------- 627
            ......:   |.....|.|..|..|..:| ||...|.|......||.|....:...|
Zfish   586 IGVMEGHYYEPMTFQGPIYTHGESPAALP-PQGMLVQPEMHLPHPTHPGLHPHQSGGPLPNPAIY 649

  Fly   628 --PPVVTQP--------TPPPAQAPPATQ---------PA---------QPYQNYNTVGGTTYFV 664
              |||...|        .|||...||...         ||         .|.......||.||:
Zfish   650 AAPPVSLSPGQPPPQQLLPPPFYPPPGVMTFGNTNYPYPAGGTLPPMYPNPQAQSQVYGGVTYY- 713

  Fly   665 PPAQTTSRPSALPQRRPTNAIPILPPSEKHKVKGGAKE 702
            ...|..::|...|.||.:|.:.:.||..:.:.:..|:|
Zfish   714 DTIQQQAQPKRSPPRRSSNPVTVRPPPPEDQSRKAAEE 751

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.