DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btz and Casc3

DIOPT Version :9

Sequence 1:	NP_001263028.1	Gene:	btz / 43331	FlyBaseID:	FBgn0045862	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_619601.2	Gene:	Casc3 / 192160	MGIID:	2179723	Length:	698	Species:	Mus musculus

Alignment Length:	757	Identity:	180/757 - (23%)
Similarity:	266/757 - (35%)	Gaps:	218/757 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 VEPGTSPTQEPNSNSHPHD--------SEYDTASDLEGGEDYDDEES--------ASGSASGSGS 89
            ||.|.:.:.| .|.....|        |:|::|.|.||.|||.:||:        |:.:|..|..
Mouse    63 VESGGAKSAE-ESECESEDGMEGDAVLSDYESAEDSEGEEDYSEEENSKVELKSEANDAADSSAK 126

  Fly    90 EEESETDDEDDEVGSETDDGEGEQAMDRSVADSEAQKK------VDEDRSNPQYIPKRGTFYEHD 148
            |:..|..:....|..|...|:|:::.:  ..:::..||      .||||.||.|||::|.|:|||
Mouse   127 EKGEEKPESKGTVTGERQSGDGQESTE--PVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHD 189

  Fly   149 DRTAETEGEILIEPENGAGQAAAEPNGELNGLAAAGATPTGQTPQISQASKTMRKWQPASGGDRW 213
            .|....|.|:             .|.|                       :..:.|:...   ||
Mouse   190 LRGQTQEEEV-------------RPKG-----------------------RQRKLWKDEG---RW 215

  Fly   214 SHDRFEATEQAPKSRAELLQTYGYDIRN----EDAPPRARRRRRYTRGPSKYSRNWEDEQAYLKA 274
            .||:|...|||||||.||:..||||||:    :|..||..|:.|:...|.: ..||..::
Mouse   216 EHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRFGSSPQR-DPNWIGDR----- 274

  Fly   275 SNKERK--------PPRPQDFPALNERKPRGPRTSSSREE------KENR---RSVAAEGLVPEK 322
            |:|..:        |||    ..:|.......|.|:||..      |:.|   |.|...|    :
Mouse   275 SSKSHRHQGPGGNLPPR----TFINRNTAGTGRMSASRNYSRSGGFKDGRTSFRPVEVAG----Q 331

  Fly   323 QQPLASSSNPHRSQERERERERERERDREPKNRNFGRMNGGPGRQ-------------------N 368
            ....::.:..|.:..|.|..|:...||..|:..  ..:.|.|.::                   .
Mouse   332 HGGRSAETLKHEASYRSRRLEQTPVRDPSPEPD--APLLGSPEKEEVASETPAAVPDITPPAPDR 394

  Fly   369 GMEFKKNNRGQQLRERERGPDQLDNRNQKPSTPRSNQQQQPQQQPHHQ---------------QQ 418
            .:|.|..:|.::.|.:.....:.......||...::....|:..|..:               :|
Mouse   395 PIEKKSYSRARRTRTKVGDAVKAAEEVPPPSEGLASTATVPETTPAAKTGNWEAPVDSTTGGLEQ 459

  Fly   419 PQQQRQPSQPQQSPQTPLSTSNLSQRLQQVQQRNDPSHVGSVQMHSLASQNQAPQQQQQQPLHQE 483
            ...|...::...||..|       ..||..:.|..|:|:     |..|  ...||..:.:.:..:
Mouse   460 DVAQLNIAEQSWSPSQP-------SFLQPRELRGVPNHI-----HMGA--GPPPQFNRMEEMGVQ 510

  Fly   484 QRNAPKRYSSLRRSQQEASQHLAEQQQQQMQQQLHLQQQQQQQQSQIMIQDP-----HVLMQIAY 543
            ...| |||||                                 |.|..:.:|     |:.:...:
Mouse   511 SGRA-KRYSS---------------------------------QRQRPVPEPPAPPVHISIMEGH 541

  Fly   544 QQQELQAQLQTMQLGPPTAAGAVPTP---------PKPHAPPAAAYPQAQAAPYYVTGTEPVPVP 599
            ....||.|      ||....|..|.|         |:.|.|....:|.....|....|.  .|.|
Mouse   542 YYDPLQFQ------GPIYTHGDSPAPLPPQGMIVQPEMHLPHPGLHPHQSPGPLPNPGL--YPPP 598

  Fly   600 VPQAPYVNPASAAYLPT---TPAAVAYAQAGPPVV--TQPTPPPAQAPPATQ-PAQPYQNYNTVG 658
            |..:|...|......||   .|..:.:.....|..  ..|.|||....|.|| |.|.|      |
Mouse   599 VSMSPGQPPPQQLLAPTYFSAPGVMNFGNPNYPYAPGALPPPPPPHLYPNTQAPPQVY------G 657

  Fly   659 GTTYFVPPAQTTSRPSALPQRRPTNAIPILPPSEKHKVKGGA 700
            |.||: .|||...:|...|.||....:.|.||..:...:|.:
Mouse   658 GVTYY-NPAQQQVQPKPSPPRRTPQPVSIKPPPPEVVSRGSS 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btz	NP_001263028.1	DUF3597	2..>43	CDD:289008	1/1 (100%)
btz	NP_001263028.1	Btz	102..243	CDD:214991	46/150 (31%)
Casc3	NP_619601.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..229		57/207 (28%)
		Necessary for RNA-binding, interaction with MAGOH and localization in nucleus speckles. /evidence=ECO:0000250	134..280		56/192 (29%)
		Sufficient to form the EJC. /evidence=ECO:0000250	134..280		56/192 (29%)
		Btz	143..245	CDD:214991	44/142 (31%)
		Nuclear localization signal 1. /evidence=ECO:0000255	201..207		2/28 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	241..457		42/231 (18%)
		Nuclear localization signal 2. /evidence=ECO:0000255	251..259		3/7 (43%)
		Necessary for localization in cytoplasmic stress granules. /evidence=ECO:0000250	374..698		80/386 (21%)
		Nuclear export signal	457..466		2/8 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..533		15/85 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..614		9/40 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..698		26/75 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845818
Domainoid	1	1.000	67	1.000	Domainoid score	I9864
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4657
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47723
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005383
OrthoInspector	1	1.000	-	-		oto94645
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13434
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3188
SonicParanoid	1	1.000	-	-		X4312
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.120