DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ALiX and Rhpn2

DIOPT Version :9

Sequence 1:NP_651582.1 Gene:ALiX / 43330 FlyBaseID:FBgn0086346 Length:836 Species:Drosophila melanogaster
Sequence 2:NP_082173.3 Gene:Rhpn2 / 52428 MGIID:1289234 Length:686 Species:Mus musculus


Alignment Length:753 Identity:150/753 - (19%)
Similarity:265/753 - (35%) Gaps:218/753 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LKKPSEVDVIKPLNNLIQSTYNGASEEEKGKYGEAVNEFSKQRNTAIWKFFEKYEASLEIVYAYY 73
            ||:..|||......:.|...|:    |:...|.:.:.:....|...  :...:.||.:|::.:|:
Mouse   117 LKETKEVDFSIVFKDFILEHYS----EDSYLYEDDIADLMDLRQAC--RTPSRDEAGVELLMSYF 175

  Fly    74 DQICALETKI--SVSELQIPFKWKDAFDKGSIFGGKISLTHTSLLYEKVCVLFNIAALQSNIAAN 136
            .|:..:|::.  ....:.:.|.|.|:|.       .:.::..:||.||..|||||.||.:.|...
Mouse   176 IQLGFVESRFFPPTRHMGLLFTWYDSFT-------GVPVSQQTLLLEKASVLFNIGALYTQIGTR 233

  Fly   137 QSLDSDDGLKLTIKLLQQSAGIFQYLKGATPAAVPSEPTPDLSQDTLTVLQALMVAQAQEVFILK 201
            .:..:..||:..:...|::||:..|||    ......|:.|:|...|:||..:|:|||||....|
Mouse   234 CNRQTQAGLESAVDAFQRAAGVLNYLK----ETFTHTPSYDMSPAMLSVLVKMMLAQAQESVFEK 294

  Fly   202 AIKDNLKDQI-----IAKLCCQAEESYADVLRAMQKESVRSLWEKEWIPTIAGKQAGFHALTQLY 261
            .....::::.     :|:...:..|:|..:..||.:|.|:......|......|...:.||...:
Mouse   295 VCLPGIQNEFFVLVKVAQEAAKVAEAYRQLHAAMSQEPVKENIPYSWASVAYVKAYHYGALAHYF 359

  Fly   262 QSLVCRAAKKIGEEIARLRNAID-LFKAAQTRSGNETYLDEYFSRAKRNLTESTKDNEFIYNEII 325
            .:.:                .|| ..|........|..|.:.:.|....:|              
Mouse   360 AATL----------------LIDHQLKPGADEDHQEKCLSQLYDRMPEGMT-------------- 394

  Fly   326 PELSTLTSPGKAQLAKPLPIAVPLAENFKDIFSSLVPVELHRALTASDMRRNEIVNVEIMKLREA 390
             .|:||.:.|:..|                    |....||||:...:....| .|: ..|||: 
Mouse   395 -PLATLKNAGQRVL--------------------LGKGHLHRAIGFHEESLRE-ANL-CKKLRD- 435

  Fly   391 TQTLNAVLASLNLPAAVETADGNSGLPPSLKEKANEVRQKGGIENVQTMLKDLPELLNRNREILD 455
            .|.|..||::.:....:               |..:.|:...:.|    |.|.|       ::|.
Mouse   436 IQVLRDVLSAAHQRTQL---------------KHTQHREDDDLLN----LIDAP-------DVLP 474

  Fly   456 ETERLLDEERDSDNQLRAQFKDRWTRISSDKLTEMFR--------TNAKKYREVITNAIEADKVV 512
            :|||          :::..|.|    .|...:|:.|:        :.:|::        ...:.:
Mouse   475 KTER----------EVKITFPD----FSKVTVTDFFQKLGPLSVFSASKRW--------SPPRGI 517

  Fly   513 RQKFEANQKGIQLLSLPPDQIQQSLPSASGSVDPNCSSVQRLKKLMDDVETIKAEREAIESELKG 577
            ....|....|..|....|.|:.        .:||:||                       :.|.|
Mouse   518 HFTVEEGDLGFTLRGNTPVQVH--------FLDPHCS-----------------------ASLAG 551

  Fly   578 ATFNMKDEFLIALQKDGAIDEPALSLARIGQVLNPLQQQVRESVE-RQQSLVSEIQSAHGAFVSE 641
            |   .:.::::::|   .:|...|:   :.:|:..|:....|.|| :..||:....|.|..  ..
Mouse   552 A---KEGDYIVSIQ---GVDCKWLT---VSEVMKLLKSFGGEEVEMKVVSLLDSTSSMHNK--CA 605

  Fly   642 TGSCGSSRDTLYQELATAFDSYIELSGNLQEGTKFYNDLTQLLVVFQNKISDFVFARKTEKEELL 706
            |.|.|..:  .|..:..:.|                               |...|.||:|  :.
Mouse   606 TYSVGMQK--TYSMICLSMD-------------------------------DDDKADKTKK--IS 635

  Fly   707 KDLT-----TESSRQACPATPALPSHYASTSGSGSDIP 739
            |.|:     |..:||...:|..||....:.|.:...:|
Mouse   636 KKLSFLSWGTSKNRQKSASTLCLPEVGLARSQNKKKLP 673

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ALiXNP_651582.1 BRO1_Alix 2..347 CDD:185763 76/345 (22%)
V_Alix 362..698 CDD:185748 59/344 (17%)
ALIX_LYPXL_bnd 415..701 CDD:290660 48/294 (16%)
MFMR 733..822 CDD:285072 1/7 (14%)
Rhpn2NP_082173.3 HR1_Rhophilin-2 27..108 CDD:212024
Interaction with Rho. /evidence=ECO:0000250 46..66
BRO1_Rhophilin_2 112..496 CDD:185772 104/489 (21%)
PDZ_signaling 522..591 CDD:238492 20/108 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2220
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.