DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ALiX and pdcd6ip

DIOPT Version :9

Sequence 1:	NP_651582.1	Gene:	ALiX / 43330	FlyBaseID:	FBgn0086346	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	XP_005159794.1	Gene:	pdcd6ip / 406669	ZFINID:	ZDB-GENE-040426-2678	Length:	871	Species:	Danio rerio

Alignment Length:	879	Identity:	351/879 - (39%)
Similarity:	539/879 - (61%)	Gaps:	63/879 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKFLGVPLKKPSEVDVIKPLNNLIQSTYNGASEEEKGKYGEAVNEFSKQRNTAIWKFFEKYEAS 65
            |:.|:.|||||.||||::|||:..:.:||  ...||:.:|..||:|.:|.|.:|:.:..:|:|:|
Zfish     1 MATFISVPLKKSSEVDLVKPLSKFVTATY--PPGEEQAEYLRAVDELNKLRKSALGRPLDKHESS 63

  Fly    66 LEIVYAYYDQICALETKISVSELQIPFKWKDAFDKGSIFGGKISLTHTSLLYEKVCVLFNIAALQ 130
            |||:..||||:||:|.|....||.:.|.|||||||||:|||.:.|...||.|||.|||||:.||.
Zfish    64 LEILLRYYDQLCAIEPKFPFPELCLTFTWKDAFDKGSLFGGSVKLALASLGYEKTCVLFNVGALA 128

  Fly   131 SNIAANQSLDSDDGLKLTIKLLQQSAGIFQYLKGATPAAVPSEPTPDLSQDTLTVLQALMVAQAQ 195
            |.||:.|:||:|:|||...|..|.::|.|.::|....:|:..|||.|:|.:|:..|..:|::|||
Zfish   129 SQIASEQNLDNDEGLKTAAKFYQLASGAFAHIKDTVLSALNREPTMDISPETVGTLSQIMLSQAQ 193

  Fly   196 EVFILKAIKDNLKDQIIAKLCCQAEESYADVLRAMQ-KESV-RSLWEKEWIPTIAGKQAGFHALT 258
            |||:|||..|.:||.|:|||..||.:.|.|..:..| ||:: :..:.::.:|.:|.|.....|..
Zfish   194 EVFVLKATSDKMKDAIVAKLANQAADYYGDAFKQCQYKENLPKYFYFQDVLPVLAAKHCMMQATA 258

  Fly   259 QLYQSLVCRAAKKIGEEIARLRNAIDLFKAAQTRSGNETYLDEYFSRAKRNLTESTKDNEFIYNE 323
            :::||.:....||.|||||||::|.:|.|.|.:|......:.:...:..|.||.:.|||:|||::
Zfish   259 EMHQSALANQKKKFGEEIARLQHAQELVKTAASRYDEYVNVKDLSDKINRALTAAKKDNDFIYHD 323

  Fly   324 IIPELSTLTSPGKAQLAKPLPIAVPLAENFKDIFSSLVPVELHRALTASDMRRNEIVNVEIMKLR 388
            .:||:..|...|||.|.|...:..||::.|.|:|..:||:.:.::::|::.|:.|.||..|..:|
Zfish   324 RVPEVKDLEHIGKASLVKATAVQTPLSQKFTDLFEKMVPMAVQQSVSAANSRKAETVNRLIGSMR 388

  Fly   389 EATQTLNAVLASLNLPAAVETADGNSGLPPSLKEKANEVRQKGGIENVQTMLKDLPELLNRNREI 453
            |||...|.||||||||||:|...|:: :|.|:.||:..:.|:||:::::.::|||||||.|||||
Zfish   389 EATNLCNGVLASLNLPAALEDLSGDA-VPQSILEKSRALIQQGGLQSIEQLIKDLPELLQRNREI 452

  Fly   454 LDETERLLDEERDSDNQLRAQFKDRWTRISSDKLTEMFRTNAKKYREVITNAIEADKVVRQKFEA 518
            |||:.::||:|..:||:||.:|..||.|..|..|.:..|.....:|.::..|::||:|||:::.|
Zfish   453 LDESLKMLDDEEATDNELRGKFNQRWNRTPSGDLYKPLRAEGNNFRNILDKAVQADQVVRERYTA 517

  Fly   519 NQKGIQLLSLPPDQIQQSLPSASGSVDPNCSSVQR-LKKLMDDVETIKAEREAIESELKGATFNM 582
            :.:.|.||..|.:::..::|||:.:.....|.|.. |:..:..::.:|.|||.:|.|:|..||::
Zfish   518 HCEMIALLCKPENELSAAIPSANPAKTLQGSEVVNVLRSQLAQLDEVKREREVLEGEVKSVTFDL 582

  Fly   583 KDEFLIALQKDGAIDEPALSLARIGQVLNPLQQQVRESVERQQSLVSEIQSAHGAF--VSETGSC 645
            ..:||.||.:||||:|..::.:.:........|:|::::.||:.|:|:||.:|..|  :.::.|.
Zfish   583 TAKFLTALAQDGAINEEVMTSSELDARYGSHNQRVQQNLRRQEELLSQIQVSHQEFSALKQSNSE 647

  Fly   646 GSSRDTLYQELATAFDSYIELSGNLQEGTKFYNDLTQLLVVFQNKISDFVFARKTEKEELLKDLT 710
            .::|:.:.::||:|.|||||:|.|::||||||||||::|:.||||.||.|||||||::||||:|.
Zfish   648 ANTREDVLKKLASAHDSYIEISSNIKEGTKFYNDLTEILLKFQNKCSDIVFARKTERDELLKELQ 712

  Fly   711 TESSRQACPATP--ALPSHYASTSGSGSDIPPG--------------------SAPSVPPAASTA 753
            ...:|:  |:.|  ::||:.::|........|.                    ..||:.|.|::|
Zfish   713 QSIARE--PSAPSFSVPSYQSNTPAPAGGPTPAPRTVFSQQQPQAKPQPPARPPPPSIAPQAASA 775

  Fly   754 NIPY-----PAQVQGMPI----PYGAQPGVPYPAYVPAP----MPQSFNPYA----TLPY-PGNY 800
            .:|.     |......|:    |..|| |.|||:|...|    ||.::||||    .:|| |  |
Zfish   776 AVPVSAPMAPGSSNPPPVAPTGPSQAQ-GPPYPSYQGYPGYYQMPMAYNPYAYGQYNMPYMP--Y 837

  Fly   801 QYQGFPQGPPPGHYGTYPGSYANQQG-GYPNQKP 833
            |.||         ...|||:.|.||. .||.|.|
Zfish   838 QAQG---------QAGYPGAPATQQPYPYPQQPP 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ALiX	NP_651582.1	BRO1_Alix	2..347	CDD:185763	150/346 (43%)
		V_Alix	362..698	CDD:185748	137/338 (41%)
		ALIX_LYPXL_bnd	415..701	CDD:290660	116/288 (40%)
		MFMR	733..822	CDD:285072	34/126 (27%)
pdcd6ip	XP_005159794.1	BRO1_Alix	2..347	CDD:185763	150/346 (43%)
		V_Alix	362..700	CDD:185748	137/338 (41%)
		ALIX_LYPXL_bnd	415..703	CDD:290660	116/287 (40%)
		RCR	<783..849	CDD:304939	27/77 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595962
Domainoid	1	1.000	312	1.000	Domainoid score	I1281
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22614
Inparanoid	1	1.050	619	1.000	Inparanoid score	I857
OMA	1	1.010	-	-		QHG53532
OrthoDB	1	1.010	-	-		D498845at33208
OrthoFinder	1	1.000	-	-		FOG0003348
OrthoInspector	1	1.000	-	-		oto41614
orthoMCL	1	0.900	-	-		OOG6_102685
Panther	1	1.100	-	-	LDO	PTHR23030
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R147
SonicParanoid	1	1.000	-	-		X4332
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940