Protein Alignment ALiX and Rhp

DIOPT Version :10

• Sequence 1: NP_651582.1
• Gene: ALiX / 43330
• FlyBaseID: FBgn0086346
• Length: 836
• Species: Drosophila melanogaster
• Sequence 2: NP_511168.3
• Gene: Rhp / 32531
• FlyBaseID: FBgn0026374
• Length: 718
• Species: Drosophila melanogaster
• Alignment Length: 806
• Identity: 153/806 - (18%)
• Similarity: 266/806 - (33%)
• Gaps: 290/806 - (35%)

  Fly     9 LKKPSEVDVIKPLNNLIQSTYNGASEEEKGKYGEAVNEFSKQRNTAIWKFFEKYEASLEIVYAYY 73
            ||:..|::.::|.::.|...|:    ||...|.:|:.:.:..|..:  |...:....:.:::.||
  Fly   127 LKETKEINFMEPFSDFILEHYS----EEPSMYIDAIADMTDTRQAS--KTPSRDALGVALLFRYY 185

  Fly    74 DQICALETKISVSE--LQIPFKWKDAFDKGSIFGGKISLTHTSLLYEKVCVLFNIAALQSNIAAN 136
            :.:..:|.:....:  |.:.|:|.|     |:.|  :.....::.:||.|.|||:..:.:.|.|.
  Fly   186 NTLYYVERRFFPPDRNLGVYFEWYD-----SLTG--VPSCQRTIAFEKACTLFNLGGIYTQIGAR 243

  Fly   137 QSLDSDDGLKLTIKLLQQSAGIFQYLKGATPAAVPSEPTPDLSQDTLTVLQALMVAQAQEVFILK 201
            ....::.||.|.:....::||:|:::......|    |:.||....|.||.:||::||:|....|
  Fly   244 HDRTTERGLDLAVDSFLRAAGVFRHIYDTFTNA----PSMDLKPQVLDVLVSLMLSQARECLFEK 304

  Fly   202 -------------AIKDNLKDQIIAKLCCQAEESYADVLRAMQKESVRSLWEKEWIPTIAGKQAG 253
                         |.:|      :|....|....|.::.:.:|.....:...:.|...:..|...
  Fly   305 LQLQIEAMSHDCQAFRD------LAGEAAQISHEYNEMHKNIQANDTHTYLPECWAGLVPVKAEL 363

  Fly   254 FHALTQLYQSLVCRAAKKIGEEIARLRNAIDLFKAAQTRSGNETYLDEYFSRAKRNLTESTKDNE 318
            :.|....|:              ||..:|.|..||:::...|:                    ..
  Fly   364 YKAFAHFYK--------------ARSIDATDELKASKSSQKNQ--------------------ES 394

  Fly   319 FIYNEIIPELSTLTSPGKAQLAKPLPIAVPLAENFKDIFSSLVPVELHRALT----ASDMRRNEI 379
            ||              |.:|                         |:.|..|    |||.....|
  Fly   395 FI--------------GNSQ-------------------------EVERITTADYGASDEASTSI 420

  Fly   380 VNVEIMKLREATQTLNAVLASLNLPAAVETADGNSGLPPSLKEKANEVRQKGGIENVQTMLKDLP 444
            .| ::..|:||.             |::|.|.....:...||.||:                 |.
  Fly   421 AN-KLAHLKEAL-------------ASIEEAQRLQRMCRFLKNKAS-----------------LT 454

  Fly   445 ELLNRNREILDETERLLDEERDSDNQLRAQFKDRWTRISSDKLTEMFRTNAKKYREVITNAIEAD 509
            |::   :|:..:::..|::.|     |:|..|:                            ||..
  Fly   455 EVM---KEVHSKSQEELEKFR-----LQASAKN----------------------------IEDG 483

  Fly   510 KVVRQKFEANQKGIQLLSLP-------PDQIQQSLPSASGS-----VDPNCSSVQRLKKLMDDVE 562
            .::.:..||:.|....|:.|       .|..::..|.|..|     ..|.|..:|:...|...|.
  Fly   484 DLLERSVEASSKFTLSLTGPDFTSHKVKDPFKRLGPIAIFSARRHWTAPRCVRLQKGSSLYHSVP 548

  Fly   563 T--IKAEREAIESELKGATFNM-KDEF-LIALQKDGAIDEPAL-------SLARIGQVLNPLQQQ 616
            :  .|...:..:.|.....:|: |:|| .......|  |.|.:       |||.:|.:
  Fly   549 SNDNKCPLDNDDDEEHDGGYNLYKEEFENFGFHVRG--DAPVIIAHVEINSLADLGGI------- 604

  Fly   617 VRESVERQQSLVSEIQS------AHGAFVSETGSCGSSRDTLYQELATAFDSYIELSGNLQEGTK 675
                  ::...:.||..      :|...|....||||   ||...:.|..|
  Fly   605 ------KEGDFIVEIAGVDVKWYSHQQVVQLIQSCGS---TLELRVITPMD-------------- 646

  Fly   676 FYNDLTQLLVVFQNKISDFVFARKTEKEELLKDLTTESSRQACPATPALPSHYASTSGSGSDIP- 739
                                       ...||.|:::.|.....|        ||:||..|..|
  Fly   647 ---------------------------RNYLKPLSSKGSLSTLSA--------ASSSGISSGFPS 676

  Fly   740 PGSAPSVP-----------PAASTAN 754
            |.|..:.|           ||.|.::
  Fly   677 PTSIAAKPKLHLKTSSSSRPAGSVSS 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALiX	NP_651582.1	BRO1_Alix	2..347	CDD:185763	69/352 (20%)
		V_Alix	362..698	CDD:185748	67/368 (18%)
		PHA03247	<710..830	CDD:223021	14/57 (25%)
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023
		BRO1_Rhophilin	122..514	CDD:185767	103/549 (19%)
		PDZ_canonical	578..642	CDD:483948	17/81 (21%)