DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ALiX and Rhpn2

DIOPT Version :9

Sequence 1:	NP_651582.1	Gene:	ALiX / 43330	FlyBaseID:	FBgn0086346	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_001100975.1	Gene:	Rhpn2 / 308516	RGDID:	1308366	Length:	686	Species:	Rattus norvegicus

Alignment Length:	735	Identity:	141/735 - (19%)
Similarity:	260/735 - (35%)	Gaps:	208/735 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LKKPSEVDVIKPLNNLIQSTYNGASEEEKGKYGEAVNEFSKQRNTAIWKFFEKYEASLEIVYAYY 73
            ||:..|||......:.|...|:    |:...|.:.:.:....|...  :...:.||.:|::.:|:
  Rat   117 LKETKEVDFSIVFKDFILEHYS----EDSYLYEDDIADLMDLRQAC--RTPSRDEAGVELLMSYF 175

  Fly    74 DQICALETKI--SVSELQIPFKWKDAFDKGSIFGGKISLTHTSLLYEKVCVLFNIAALQSNIAAN 136
            .|:..:|::.  ....:.:.|.|.|:|.       .:.::..:||.||..:||||.||.:.|...
  Rat   176 IQLGFVESRFFPPTRHMGLLFTWYDSFT-------GVPVSQQTLLLEKASILFNIGALYTQIGTR 233

  Fly   137 QSLDSDDGLKLTIKLLQQSAGIFQYLKGATPAAVPSEPTPDLSQDTLTVLQALMVAQAQEVFILK 201
            .:..::.||:..:...|::||:..|||    ......|:.|:|...|:||..:|:|||||....|
  Rat   234 CNRQTEAGLESAVDAFQRAAGVLNYLK----ETFTHTPSYDMSPAMLSVLVKMMLAQAQESVFEK 294

  Fly   202 AIKDNLKDQ--IIAKLCCQAEE---SYADVLRAMQKESVRSLWEKEWIPTIAGKQAGFHALTQLY 261
            .....::::  ::.|:..:|.:   :|..:..||.:|.|:......|......|...:.||...:
  Rat   295 ICLLGIQNEFFVLVKVAQEAAKVAAAYRQLHAAMSQEPVKENIPYSWASVAYVKAYHYGALAHYF 359

  Fly   262 QSLVCRAAKKIGEEIARLRNAID-LFKAAQTRSGNETYLDEYFSRAKRNLTESTKDNEFIYNEII 325
            .:.:                .|| ..|........|..|.:.:.|....:|
  Rat   360 AATL----------------LIDHQLKPGADEDHQEKCLSQLYDRMPEGMT-------------- 394

  Fly   326 PELSTLTSPGKAQLAKPLPIAVPLAENFKDIFSSLVPVELHRALTASDMRRNEIVNVEIMKLREA 390
             .|:||.:.|:..|                    |....||||:   |..:..:....:.|....
  Rat   395 -PLATLKNDGQRVL--------------------LGKGHLHRAI---DYHKESLREANLCKKLRD 435

  Fly   391 TQTLNAVLASLNLPAAVETADGNSGLPPSLKEKANEVRQKGGIENVQTMLKDLPELLNRNREILD 455
            .|.|..||::.:....:               |..:.:|...:.|    |.|.|       ::|.
  Rat   436 IQVLRDVLSAAHQRTQL---------------KYTQHQQDDDLLN----LIDAP-------DVLP 474

  Fly   456 ETERLLDEERDSDNQLRAQFKDRWTRISSDKLTEMFR--------TNAKKYREVITNAIEADKVV 512
            :|||          :::..|.|    .|...:|:.|:        :.:|::        ...:.:
  Rat   475 KTER----------EVKITFPD----FSKVTVTDFFQKLGPLSVFSASKRW--------SPPRGI 517

  Fly   513 RQKFEANQKGIQLLSLPPDQIQQSLPSASGSVDPNCSSVQRLKKLMDDVETIKAEREAIESELKG 577
            ..:.|....|..|....|.|:.        .:||:||                       :.|.|
  Rat   518 HFRVEEGDLGFTLRGNTPVQVH--------FLDPHCS-----------------------ASLAG 551

  Fly   578 ATFNMKDEFLIALQKDGAIDEPALSLARIGQVLNPLQQQVRESVE-RQQSLVSEIQSAHGAFVSE 641
            |   .:.::::::|   .:|...|:   :.:|:..|:....|.|| :..||:....|.|..  ..
  Rat   552 A---KEGDYIVSIQ---GLDCKWLT---VSEVMKLLKSFGGEEVEMKVVSLLDSTSSMHNK--CA 605

  Fly   642 TGSCGSSRDTLYQELATAFDSYIELSGNLQEGTKFYNDLTQLLVVFQNKISDFVFARKTEKEELL 706
            |.|.|..:  .|..:..:.|     ..:..:.||                       |..|:...
  Rat   606 TYSVGMQK--TYSMICLSMD-----DDDKADKTK-----------------------KISKKPSF 640

  Fly   707 KDLTTESSRQACPATPALPS 726
            ...:|..:||...:|..||:
  Rat   641 LSWSTSKNRQKSASTLCLPN 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ALiX	NP_651582.1	BRO1_Alix	2..347	CDD:185763	75/345 (22%)
		V_Alix	362..698	CDD:185748	57/344 (17%)
		ALIX_LYPXL_bnd	415..701	CDD:290660	48/294 (16%)
		MFMR	733..822	CDD:285072
Rhpn2	NP_001100975.1	HR1_Rhophilin-2	27..108	CDD:212024
		BRO1_Alix_like	112..496	CDD:301330	100/489 (20%)
		PDZ_signaling	520..591	CDD:238492	20/110 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810