DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ALiX and Rhpn1

DIOPT Version :9

Sequence 1:	NP_651582.1	Gene:	ALiX / 43330	FlyBaseID:	FBgn0086346	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	XP_006241962.1	Gene:	Rhpn1 / 300030	RGDID:	1305688	Length:	662	Species:	Rattus norvegicus

Alignment Length:	466	Identity:	120/466 - (25%)
Similarity:	188/466 - (40%)	Gaps:	72/466 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LKKPSEVDVIKPLNNLIQSTYNGASEEEKGKYGEAVNEFSKQRNTAIWKFFEKYEASLEIVYAYY 73
            ||:..|:|...||..||...:.    |:...|...:.|....|...  :...:.|..|:::.|||
  Rat   121 LKETKELDWATPLKELISEHFG----EDGASYETEIQELEDLRQAT--RTPSRDEVGLDLLAAYY 179

  Fly    74 DQICALETKISVSELQIP---FKWKDAFDKGSIFGGKISLTHTSLLYEKVCVLFNIAALQSNIAA 135
            .|:|.|:.:. .|..:.|   |.|.|     |:.|  :.....:|.:||..|||||.||.:.|.|
  Rat   180 SQLCFLDARF-FSPARSPGLLFHWYD-----SLTG--VPAQQRALAFEKGSVLFNIGALHTQIGA 236

  Fly   136 NQSLDSDDGLKLTIKLLQQSAGIFQYLKGATPAAVPSEPTPDLSQDTLTVLQALMVAQAQEVFI- 199
            .|.....:|.....:..|::||.|:.|:.....|    |:||:|..:|::|:.||||||||...
  Rat   237 RQDCSCTEGTSQAAEAFQRAAGAFRLLRENFSHA----PSPDMSAASLSMLEQLMVAQAQECIFR 297

  Fly   200 -----LKAIKDNLKDQI-IAKLCCQAEESYADVLRAMQKESVRSLWEKEWIPTIAGKQAGFHALT 258
                 ..|..|...||: :|:...|....|..|.|||.:..||......|......|...|.||.
  Rat   298 GLLLRASATPDICPDQLQLAQEATQVATEYGLVHRAMAQPPVRDYLPASWTNLARVKAEHFCALA 362

  Fly   259 QLYQSL-VCRAAKKIGEEIARLRNAIDLFKAAQTRSGNETYLDEYFSRAKRNLTESTKDNEFIYN 322
            ..:.:: :|.:......|::|..   |:|:.:.|.......|.:: ...:|.|.::......:..
  Rat   363 HYHAAMALCESTSAAKGELSRQE---DIFQPSATCEPQGPTLPQH-PEERRKLAKAHLKRAILGQ 423

  Fly   323 EIIPELSTLTS-PGKAQLAKPLPIAVPLAENFKDIFSSLVPVELHRALTA-SDMRRNEIVNVEIM 385
            |....|.||.. |.|.                 |:...:|...|.|:||. |::.|.:    :..
  Rat   424 EEALRLHTLCRVPRKV-----------------DLLQVVVTQALRRSLTKYSELERED----DFF 467

  Fly   386 KLREA----TQTLNAVLASLNLPAAVETADGNSGLPP----SLKEK------ANEVRQKGGIENV 436
            :..||    .:|..|...|:...:.|:..|....|.|    |.|.:      .:..|.:||..
  Rat   468 EAMEAPDIQPKTHQAPEVSIPSLSQVKVTDFFHRLGPLSVFSTKNRWQLVGPVHMTRGEGGFG-- 530

  Fly   437 QTMLKDLPELL 447
            .|:..|.|.|:
  Rat   531 FTLRGDSPVLI 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ALiX	NP_651582.1	BRO1_Alix	2..347	CDD:185763	94/349 (27%)
		V_Alix	362..698	CDD:185748	24/101 (24%)
		ALIX_LYPXL_bnd	415..701	CDD:290660	11/43 (26%)
		MFMR	733..822	CDD:285072
Rhpn1	XP_006241962.1	HR1	28..112	CDD:294066
		BRO1_Rhophilin_1	116..499	CDD:185771	109/420 (26%)
		PDZ_signaling	520..594	CDD:238492	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810