DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ALiX and SPAC17G6.05c

DIOPT Version :9

Sequence 1:	NP_651582.1	Gene:	ALiX / 43330	FlyBaseID:	FBgn0086346	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_594252.1	Gene:	SPAC17G6.05c / 2542419	PomBaseID:	SPAC17G6.05c	Length:	775	Species:	Schizosaccharomyces pombe

Alignment Length:	783	Identity:	161/783 - (20%)
Similarity:	316/783 - (40%)	Gaps:	113/783 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KKPSEVDVIKPLNNLIQSTYNGASEEEKGKYGEAVNEFSKQRNTAIWKFFEKYEASLEIVYAYYD 74
            |:....|.::|....:...|..:.:.|     :.:..|:..|..|  ...:...|..:|:|:||.
pombe    14 KETKHSDWVEPFTTFVSRIYGNSVDVE-----DQIKAFNTLRENA--ADVDDTVAGKDILYSYYG 71

  Fly    75 QICALETKISV--SELQIPFKWKDAFDKGSIFGGKISLTHTSLLYEKVCVLFNIAALQSNIAANQ 137
            |:..|..:...  :.:.|.|:|.|..|..:.|     :..:||.:||..||||:.:|.|.:|||.
pombe    72 QLDYLSFRFPTGGNGINISFEWSDILDPDADF-----VKQSSLAFEKASVLFNLVSLLSRMAANH 131

  Fly   138 -SLDSDDGLKLTIKLLQQSAGIFQYLKGATPAAVPSEPTPDLSQDTLTVLQALMVAQAQEVFI-- 199
             |..:.|..|.....||.::||.:.|:.:...|    |..||..:.|..:..|.:.||||..:
pombe   132 ASAYTVDDYKAAANCLQCASGIAKLLRESFIHA----PGRDLDSNFLLGIYNLFLGQAQECVLGH 192

  Fly   200 --LKAIKDNLKDQIIAKLCCQAEESYADVLRAMQKESVRSLWEKEWIPTIAGKQAGFHALTQLYQ 262
              ..|...|:...:.||:...|...|...:.|.  ||:.......:|...:.|:|.....:..:.
pombe   193 MSFSASDSNMNYSLAAKIASSAATLYDSCVHAF--ESMEPACNPNFIRLASAKKAALEGFSSYFM 255

  Fly   263 SLVCRAAKKIGEEIARLRNAIDLFKAAQ---------TRSGNETYLDEY------FSRAKRN--L 310
            :.......|.|..|..|:.|..:..:||         |...::..|.:|      |.::..:  |
pombe   256 ARAQLEKSKQGLAIGYLQQAKSILSSAQKLFNGIKLSTDFIHKPSLSDYPQTISTFIKSSLSHLL 320

  Fly   311 TESTKDNEFIYNEII------PELSTLTSPGKAQLAKPLPI--AVPLAENFK--------DIFSS 359
            ..:.|||:|::::::      |::|.|      |...|||:  .....:.|:        |:|.:
pombe   321 KTAEKDNDFVFHDLVVKEVELPKISPL------QALPPLPLEKLYGSQDGFETAKKIVGDDLFKA 379

  Fly   360 LVPVELHRALTASDMRRNEIVNV---EIMKLREATQTLNAVLASLNLPAAVETADGNSG---LPP 418
            .||   ....|||.:...|...|   |..::......:..|.|||:|....|....:|.   :|.
pombe   380 FVP---SAVTTASSLYSEETAKVFRAEQAEVERQNTQMATVFASLDLSRLQEITHSDSKTNFIPK 441

  Fly   419 SLKEKANEVRQKGGIENVQTMLKDLPELLNRNREILDETERLLDEERDSDNQLRAQFKDRWTRIS 483
            .|.|..:::........:..:.....:|    ::|:.:.:..|:.|.:.:.:::|:....||...
pombe   442 ELIEARSQLISFNPTFKIHELFAKSTKL----KQIIAKIKSDLEVEANENAKMKAKLGPSWTLSD 502

  Fly   484 SDKLTEMFRTNAKKYREVITNAIEADKVVRQKFEANQKGIQLLSLPPDQIQQSLPSASGSVDPNC 548
            |.:....:::....|.:.:..|...|..:.|::...:..::.| ....:|...|.|:..|.|.:.
pombe   503 SLEFAAPYQSELNNYLKTLAEASATDSAISQQYALVKDDVETL-CNSSKISALLESSISSTDNSG 566

  Fly   549 SS------------------VQRLKKLMDDVETIKAEREAIESELKGATFNMKDEFLIAL----- 590
            .|                  :..|::|...|:.:..||:.....|:...  ::|:...:|
pombe   567 QSLLDIPIEQEEQERDMKIQLDLLEELQSRVQKLVPERQTTLQALQQKC--LQDDISESLMQNSK 629

  Fly   591 QKDGAIDEPALSLARIGQVLNPLQQQVRESVERQQSLVSEIQSA------HGAFVSET---GSCG 646
            :||.|:|...|....: :..:||:.::..|..:||.|::|:::.      :..|:.:.   .:..
pombe   630 RKDSALDTNQLFELEL-KKFDPLRNRLHASYRQQQLLLNEMRNVTQKLKQNPEFLRKMEVYNNQF 693

  Fly   647 SSRDTLYQELATAFDSYIELSGNLQEGTKFYNDLTQLLVVFQNKISDFVFARKTEKEELLKDLTT 711
            |....|...|.::..:...:|..:.:|.::|..:.|.|......:.:.:..|:.:....|..|::
pombe   694 SKNKELCSNLLSSSLTAKAISEGVSKGLEYYKTVEQRLAEINKTLGEQLLLRRKQGATCLSKLSS 758

  Fly   712 ESS 714
            .||
pombe   759 SSS 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ALiX	NP_651582.1	BRO1_Alix	2..347	CDD:185763	87/368 (24%)
		V_Alix	362..698	CDD:185748	65/373 (17%)
		ALIX_LYPXL_bnd	415..701	CDD:290660	52/320 (16%)
		MFMR	733..822	CDD:285072
SPAC17G6.05c	NP_594252.1	BRO1_Alix_like	8..345	CDD:301330	81/348 (23%)
		V_ScBro1_like	382..745	CDD:185750	65/373 (17%)
		ALIX_LYPXL_bnd	439..748	CDD:290660	52/316 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	112	1.000	Inparanoid score	I1561
OMA	1	1.010	-	-		QHG53532
OrthoFinder	1	1.000	-	-		FOG0003348
OrthoInspector	1	1.000	-	-		otm47081
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23030
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R147
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.000