DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ALiX and ego-2

DIOPT Version :9

Sequence 1:	NP_651582.1	Gene:	ALiX / 43330	FlyBaseID:	FBgn0086346	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_001251634.1	Gene:	ego-2 / 190251	WormBaseID:	WBGene00001215	Length:	1494	Species:	Caenorhabditis elegans

Alignment Length:	984	Identity:	200/984 - (20%)
Similarity:	375/984 - (38%)	Gaps:	231/984 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LNNLIQSTYNGASEEEKGKYGEAVNEFSKQRNTAIWKFFEKYEASLEI--------VYAYYDQIC 77
            :...|..|:|....:    |..|.:|.::.          |:||::..        :..||.|:|
Worm    33 MKEYILLTFNADPHD----YDSAFDELTQM----------KFEANVPTPSVEQTLKLKRYYGQLC 83

  Fly    78 ALETKISV---SELQIPFKWKDAFDKGSIFGGKISLTHTSLLYEKVCVLFNIAALQSNIAANQSL 139
            .::.:..:   .:|:.||.|.|...  .|...:..:|...:.:||..|:|||.|..:..||.|:.
Worm    84 MMQKRFPMGAGEQLETPFAWHDGLI--DIRSAQSEVTICDIEFEKASVMFNIGACHAQYAAEQTR 146

  Fly   140 DSDDGLKLTIKLLQQSAGIFQYLKGATPAAVPSEPTPDLSQDTLTVLQALMVAQAQEVFILKAIK 204
            |:.|.:|......|.:|..|:.|.....:.: ..|:.||..:.::....:|:|||||..:.|::.
Worm   147 DTQDCIKAAFMHFQYAAYAFEQLNSFRNSDI-FYPSVDLDANVISFYYKVMIAQAQECLVQKSLL 210

  Fly   205 DNLKDQIIAKLCCQAEESYADVLRAMQK------ESVRSLWEKEWIPTIAGKQAGFHALTQLYQS 263
            ||....:||||....:|:|....:.:.:      |||:..:.|     |...::..:|:. .|.|
Worm   211 DNRSAIVIAKLSLWLQEAYDSAAKIVDEWSVNIPESVQRYYAK-----ICSLKSAMYAVI-AYMS 269

  Fly   264 L---VCRAAKKIGEEIARLRNA---IDLFKAAQTRSG--------NETYLDEYFSRAKRNLTEST 314
            .   :.:..||:|..:.....|   ::|..:..::..        ..::|.:..|..:||   :.
Worm   270 FGDNLEKEDKKMGWRLQYYNIANKYMELLSSNHSKMRERYPELFVTSSFLFDVISAKQRN---AE 331

  Fly   315 KDNEFIYNEIIPE----LSTLTSPGKAQLAKPLPIAV-PLAENF--KDIFSSLVPVELHRALTAS 372
            |:|:|||::.:|:    :..:...|...:.|...::. ||..:.  .|:|..|:|..:..|:...
Worm   332 KENDFIYHDRVPKQEDAIDAVQKDGGGAMCKVKTLSFDPLDPSVCGCDLFGKLLPTFVQDAVKKY 396

  Fly   373 DMRRNEIVNVEIMKLREATQTLNAVLASLNLPAAVETADGNSGLPPSLKEKANEVRQKGGIENVQ 437
            ...:::       .|||..:.:.:....||....:...|       .|:...||     |..:.:
Worm   397 SDDKDQ-------ALREIKECVRSYDEHLNYQLQLAEFD-------KLRFMLNE-----GKRSRE 442

  Fly   438 TMLKDLPELLNRNREIL---DETERLLDEERDSDNQLRAQFKDRWTRISSDKLTEMFRTNAK--- 496
            ...:...:|:.||.::.   |....|:|:..:|.:..|.......|.:|..:..::.:::.:
Worm   443 AWFEISEDLMKRNADMTSYPDCVPNLIDKMGESSDTARVAEAKLNTLLSKLRAIDLQKSSIRSDE 507

  Fly   497 ------KYREVITNAIEADKV----VRQKFEANQKGIQLLSLPPDQIQQSL--PSASGSVDPNCS 549
                  |..|.:...:|..|.    :.:....:...:|||:||..::...:  |...|.: .|.|
Worm   508 GFILIQKELERLAEHLEQAKAHNVSLNKAIAQHSANLQLLTLPCREMWMKIVPPEQQGEM-RNGS 571

  Fly   550 SVQRL--KKLMDDVETIKAER----EAIESELKGATFNMKDEFLIALQKDGAIDEPALSLARIGQ 608
            |.:.|  :|:::.|..::|:|    |..|::||....:.|   |:...:.||.:.....|.:...
Worm   572 SPEELQVRKMIEKVMEMQAQRRKLVEQFEADLKADNISNK---LMGTNERGAEEIMKSELTKHTN 633

  Fly   609 VLNPLQQQVRESVERQQSLVSEIQSAHGAFVSETGSCGSSRDTLYQ----ELATAFDSYIELSGN 669
            :    ||.:|.::..|.:::.....|:..|..|..:..:.::. |:    ||..:::.|.::|..
Worm   634 I----QQLIRLNITAQDAILRAFADANADFFEERLAMSTKKEE-YEKRVSELCASYEVYRDVSKK 693

  Fly   670 LQEGTKFYNDLTQLLVVFQNKI--SDFVFARKTEKEELLK---DLTTESSRQACPATPAL----- 724
            :.||.:||..|......|...:  .:..:..:.||:|..|   :......|.:..|..||
Worm   694 VDEGEQFYRQLMARCDQFAIPVHAMEEQYREEMEKKERAKKEAEHHLNQIRMSRDAQNALMDFGG 758

  Fly   725 -----------------PSHYASTSGSG----------------------SDIPPGSAPSVPPAA 750
                             ||..|:.:|:|                      :.||....|..|..:
Worm   759 GRGGGAPGARAQQQAYQPSRGAAGAGAGAPRGPRLGDFMDSYRARKQAPQAQIPEDQGPPSPTPS 823

  Fly   751 STANIPYPAQ----------VQGMP-----------------------IPYGAQPGVPY----PA 778
            |..:.|..:|          .||.|                       .|:||.||.|:    |.
Worm   824 SICDFPVQSQRSQRFGAFEGAQGAPGAQRGYQGPHSPVPGALTGSQASGPFGAPPGAPHGYGAPL 888

  Fly   779 YVPAPMPQSFNP-----------------------YATLPYPGNYQYQGFPQGPPPGHYGTYPGS 820
            ..|...|..::|                       :|..||||:......|:..|...||...||
Worm   889 QAPPQAPYGYDPSRYQDPSTYPAPPPILPGSAAYEHAIRPYPGDTGSYQVPRIVPGAQYGAQAGS 953

  Fly   821 --YANQQGG 827
              |...|.|
Worm   954 GAYFGAQFG 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ALiX	NP_651582.1	BRO1_Alix	2..347	CDD:185763	80/360 (22%)
		V_Alix	362..698	CDD:185748	68/365 (19%)
		ALIX_LYPXL_bnd	415..701	CDD:290660	60/315 (19%)
		MFMR	733..822	CDD:285072	33/172 (19%)
ego-2	NP_001251634.1	BRO1_Alix_like	2..381	CDD:387372	83/373 (22%)
		V_HD-PTP_like	386..722	CDD:185747	68/363 (19%)
		PRK07764	<840..1227	CDD:236090	27/123 (22%)
		PRK12323	<1158..>1308	CDD:237057
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D498845at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R147
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950